Amyloid-β interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons

2009 ◽  
Vol 87 (10) ◽  
pp. 2297-2307 ◽  
Author(s):  
Tsan-Ju Chen ◽  
Dean-Chuan Wang ◽  
Shun-Sheng Chen
Keyword(s):  
Signaling Pathway ◽  
Neurotrophic Factor ◽  
Cortical Neurons ◽  
Amyloid Β ◽  
Brain Derived Neurotrophic Factor ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Rat Cortical Neurons

Activity Dependent Mammalian Target of Rapamycin Pathway and Brain Derived Neurotrophic Factor Release is Required for the Rapid Antidepressant Effects of Puerarin

2018 ◽  
Vol 46 (07) ◽  
pp. 1519-1534 ◽  
Author(s):  
Chih-Chia Huang ◽  
Mang-Hung Tsai ◽  
Ya-Chieh Wu ◽  
Kuang-Ti Chen ◽  
Han-Wen Chuang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Neurotrophic Factor ◽  
Forced Swim Test ◽  
Neuroprotective Effect ◽  
Mammalian Target Of Rapamycin ◽  
Brain Derived Neurotrophic Factor ◽  
Mtor Signaling ◽  
Target Of Rapamycin ◽  
Antidepressant Effect ◽  
Mtor Signaling Pathway

Puerarin is a traditional Chinese medicine with beneficial effects of reduced depression-like behaviors in mice with stress. Previous studies also show that puerarin can produce neuroprotective effect via activating the Akt or increased brain-derived neurotrophic factor (BDNF) expression. Interestingly, BDNF and Akt downstream target, mammalian target of rapamycin (mTOR) mediate the fast-acting antidepressant properties of ketamine. Until now, the involvement of the mTOR signaling pathway or BDNF on puerarin-induced antidepressant effect remains unknown. We aimed to investigate whether the antidepressant-like effect induced by puerarin would associate mTOR signaling pathway and BDNF release. The antidepressant-like effects of puerarin were evaluated using the forced swim test. The activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionaic acid receptor (AMPAR)-mTOR signaling pathway and release of BDNF in the prefrontal cortex were determined. We also investigated the effect of puerarin on AMPAR trafficking through measuring the PKA phosphorylation of AMPAR subunit GluR1. Our present results show that puerarin exerted antidepressant-like responses that was mediated by AMPAR-induced mTOR signaling pathway and associated with increased BDNF release. Moreover, a significant increase in the GluR1 phosphorylation at its PKA site was noted following puerarin treatment. Our findings are the first to demonstrate that the antidepressant-like actions of puerarin require AMPAR–mTOR signaling pathway activation, are associated with an increased BDNF level and facilitate AMPAR membrane insertion. These findings provide preclinical evidence that puerarin may possess antidepressant property which is mediated by the glutamatergic system.

Brain derived neurotrophic factor induction of N-methyl-D-aspartate receptor subunit NR2A expression in cultured rat cortical neurons

1998 ◽  
Vol 252 (3) ◽  
pp. 211-214 ◽  
Author(s):  
Daniel L Small ◽  
Christine L Murray ◽  
Geoffrey A.R Mealing ◽  
Michael O Poulter ◽  
Alastair M Buchan ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Cortical Neurons ◽  
Brain Derived Neurotrophic Factor ◽  
Receptor Subunit ◽  
Aspartate Receptor ◽  
Rat Cortical Neurons

Phosphorylation of the SRF coactivator MKL1 induced by brain-derived neurotrophic factor (BDNF) in rat cortical neurons

2011 ◽  
Vol 71 ◽  
pp. e335
Author(s):  
Akiko Tabuchi ◽  
Yuta Ishibashi ◽  
Jyunya Tsujii ◽  
Mitsuru Ishikawa ◽  
Mamoru Fukuchi ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Cortical Neurons ◽  
Brain Derived Neurotrophic Factor ◽  
Rat Cortical Neurons
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