Fibroblast growth factor-9 inhibits astrocyte differentiation of adult mouse neural progenitor cells

2009 ◽  
Vol 87 (10) ◽  
pp. 2201-2210 ◽  
Author(s):  
Maggie Lum ◽  
Alisa Turbic ◽  
Branka Mitrovic ◽  
Ann M. Turnley
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Adult Mouse ◽  
Neural Progenitor ◽  
Fibroblast Growth ◽  
Astrocyte Differentiation

scholarly journals Neurospheres Induced from Human Adipose-Derived Stem Cells as a New Source of Neural Progenitor Cells

2019 ◽  
Vol 28 (1_suppl) ◽  
pp. 66S-75S ◽  
Author(s):  
Chunyang Peng ◽  
Li Lu ◽  
Yajiao Li ◽  
Jingqiong Hu
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Adipose Derived Stem Cells ◽  
Fibroblast Growth ◽  
Adipose Derived Stem Cell

Human adipose-derived stem cells are used in regenerative medicine for treating various diseases including osteoarthritis, degenerative arthritis, cartilage or tendon injury, etc. However, their use in neurological disorders is limited, probably due to the lack of a quick and efficient induction method of transforming these cells into neural stem or progenitor cells. In this study, we reported a highly efficient and simple method to induce adipose-derived stem cells into neural progenitor cells within 12 hours, using serum-free culture combined with a well-defined induction medium (epidermal growth factor 20 ng/ml and basic fibroblast growth factor, both at 20 ng/ml, with N2 and B27 supplements). These adipose-derived stem cell-derived neural progenitor cells grow as neurospheres, can self-renew to form secondary neurospheres, and can be induced to become neurons and glial cells. Real-time polymerase chain reaction showed significantly upregulated expression of neurogenic genes Sox2 and Nestin with a moderate increase in stemness gene expression. Raybio human growth factor analysis showed a significantly upregulated expression of multiple neurogenic and angiogenic cytokines such as brain-derived neurotrophic factor, glial cell line-derived neurotrophic growth factor, nerve growth factor, basic fibroblast growth factor and vascular endothelial growth factor etc. Therefore, adipose-derived stem cell-derived neurospheres can be a new source of neural progenitor cells and hold great potential for future cell replacement therapy for treatment of various refractory neurological diseases.

Expression of Fibroblast Growth Factor Receptor in Adult Mouse Utricle Damaged by Streptomycin Sulfate

ORL ◽  
1998 ◽  
Vol 60 (1) ◽  
pp. 1-3
Author(s):  
Hiroshi Yamashita ◽  
Toshikazu Gondo ◽  
Tokuhiro Ishihara ◽  
Masahiro Takahashi
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Adult Mouse ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Streptomycin Sulfate

Chemokine receptor CXCR4 signaling modulates the growth factor-induced cell cycle of self-renewing and multipotent neural progenitor cells

Glia ◽  
2010 ◽  
Vol 59 (1) ◽  
pp. 108-118 ◽  
Author(s):  
Meizhang Li ◽  
Cathleen J. Chang ◽  
Justin D. Lathia ◽  
Li Wang ◽  
Holly L. Pacenta ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Growth Factor ◽  
Progenitor Cells ◽  
Chemokine Receptor ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Cxcr4 Signaling ◽  
Chemokine Receptor Cxcr4
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