N-acetylcysteine prevents β-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons

2008 ◽  
Vol 86 (12) ◽  
pp. 2685-2695 ◽  
Author(s):  
Ya-Hsin Hsiao ◽  
Po-See Chen ◽  
Shiu-Hwa Yeh ◽  
Chia-Ho Lin ◽  
Po-Wu Gean
Keyword(s):  
Cortical Neurons ◽  
Cyclin Dependent Kinase ◽  
Amyloid Toxicity ◽  
Cultured Cortical Neurons ◽  
Β Amyloid ◽  
Cyclin Dependent Kinase 5

scholarly journals Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases β-amyloid toxicity in cortical neurons

2003 ◽  
Vol 84 (2) ◽  
pp. 347-362 ◽  
Author(s):  
Guibin Li ◽  
Alexander Faibushevich ◽  
Brandon J. Turunen ◽  
Sung Ok Yoon ◽  
Gunda Georg ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Cyclin Dependent Kinase ◽  
Amyloid Toxicity ◽  
Β Amyloid ◽  
Cyclin Dependent Kinase 5

scholarly journals Neuroprotective effects of genistein and folic acid on apoptosis of rat cultured cortical neurons induced by β-amyloid 31-35

2009 ◽  
Vol 102 (5) ◽  
pp. 655-662 ◽  
Author(s):  
Huan-Ling Yu ◽  
Li Li ◽  
Xiao-Hong Zhang ◽  
Li Xiang ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cortical Neuron ◽  
Cortical Neurons ◽  
Tail Length ◽  
Underlying Mechanism ◽  
Pcr Analysis ◽  
Neuroprotective Effects ◽  
Regulated Expression ◽  
Cultured Cortical Neurons ◽  
Β Amyloid

Genistein and folic acid have been reported respectively to protect against the development of cognitive dysfunction; however, the underlying mechanism(s) for this protection remain unknown. In this report, the mechanism(s) contributing to the neuroprotective effects of genistein and folic acid were explored using rat cortical neuron cultures. We found that genistein and folic acid, both separately and collaboratively, increased cell viability and mitochondrial membrane potential in β-amyloid (Aβ) 31-35-treated neurons. Furthermore, reduced percentage of comet cells and shortened tail length were observed in the neurons treated with genistein or folic acid. A more significant reduction in tail length of the comet neurons was observed in the co-administered neurons. RT-PCR analysis of the cultured cortical neurons showed down-regulated expression of p53, bax and caspase-3, but up-regulated expression of bcl-2 in the three neuroprotective treatment groups compared with neurons from the Aβ31-35 solo-treated group. In a nuclear dyeing experiment using Hoechst 33342, we found that both genistein and folic acid prevent neuronal apoptosis. Collectively, these findings suggest that the mechanism underlying the neuroprotection of genistein and folic acid singly or in combination observed in cultured cortical neuron studies might be related to their anti-apoptotic properties.

scholarly journals β-Amyloid 25-35 Peptide Reduces the Expression of Glutamine Transporter SAT1 in Cultured Cortical Neurons

2007 ◽  
Vol 33 (2) ◽  
pp. 248-256 ◽  
Author(s):  
Doungjai Buntup ◽  
Øivind Skare ◽  
Tom Tallak Solbu ◽  
Farrukh A. Chaudhry ◽  
Jon Storm-Mathisen ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Glutamine Transporter ◽  
Cultured Cortical Neurons ◽  
Β Amyloid

Carbachol blocks β-amyloid fragment 31–35-induced apoptosis in cultured cortical neurons

2000 ◽  
Vol 51 (6) ◽  
pp. 465-470 ◽  
Author(s):  
Xiu-Zhen Yan ◽  
Rong Xiao ◽  
Yan Dou ◽  
Su-Dand Wang ◽  
Zhong-Dong Qiao ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Cultured Cortical Neurons ◽  
Β Amyloid ◽  
Induced Apoptosis

Estrogen Receptors and Type 1 Metabotropic Glutamate Receptors Are Interdependent in Protecting Cortical Neurons against β-Amyloid Toxicity

2011 ◽  
Vol 81 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Simona Federica Spampinato ◽  
Gemma Molinaro ◽  
Sara Merlo ◽  
Luisa Iacovelli ◽  
Filippo Caraci ◽  
...  
Keyword(s):  
Estrogen Receptors ◽  
Glutamate Receptors ◽  
Cortical Neurons ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Amyloid Toxicity ◽  
Β Amyloid
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