Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats

2008 ◽  
Vol 86 (11) ◽  
pp. 2524-2534 ◽  
Author(s):  
Sarah K. McCann ◽  
Gregory J. Dusting ◽  
Carli L. Roulston
Keyword(s):  
Nadph Oxidase ◽  
Superoxide Generation ◽  
Conscious Rats ◽  
Endothelin 1 ◽  
Early Increase

scholarly journals Endothelinergic Contractile Hyperreactivity in Rat Contralateral Carotid to Balloon Injury: Integrated Role for ETB Receptors and Superoxide Anion

2017 ◽  
Vol 2017 ◽  
pp. 1-13
Author(s):  
Larissa Pernomian ◽  
Lilian R. Gimenes ◽  
Mayara S. Gomes ◽  
Bruno N. do Vale ◽  
Cristina R. B. Cardoso ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Superoxide Anion ◽  
Calcium Mobilization ◽  
Balloon Injury ◽  
Superoxide Generation ◽  
Response Curves ◽  
Endothelin 1 ◽  
Functional Assays ◽  
Superoxide Dismutase Mimic ◽  
Lucigenin Chemiluminescence

Temporal consequences of neurocompensation to balloon injury on endothelinergic functionality in rat contralateral carotid were evaluated. Rats underwent balloon injury in left carotid and were treated with CP-96345 (NK1 antagonist). Concentration-response curves for endothelin-1 were obtained in contralateral (right) carotid at 2, 8, 16, 30, or 45 days after surgery in the absence or presence of BQ-123 (ETA antagonist), BQ-788 (ETB antagonist), or Tempol (superoxide-dismutase mimic). Endothelin-1-induced calcium mobilization was evaluated in functional assays carried out with BQ-123, BQ-788, or Tempol. Endothelin-1-induced NADPH oxidase-driven superoxide generation was measured by lucigenin chemiluminescence assays performed with BQ-123 or BQ-788. Endothelin-1-induced contraction was increased in contralateral carotid from the sixteenth day after surgery. This response was restored in CP-96345-treated rats. Endothelium removal or BQ-123 did not change endothelin-1-induced contraction in contralateral carotid. This response was restored by BQ-788 or Tempol. Contralateral carotid exhibited an increased endothelin-1-induced calcium mobilization, which was restored by BQ-788 or Tempol. Contralateral carotid exhibited an increased endothelin-1-induced lucigenin chemiluminescence, which was restored by BQ-788. We conclude that the NK1-mediated neurocompensatory response to balloon injury elicits a contractile hyperreactivity to endothelin-1 in rat contralateral carotid by enhancing the muscular ETB-mediated NADPH oxidase-driven generation of superoxide, which activates calcium channels.

Grape pomace enzymatic extract restores vascular dysfunction evoked by endothelin-1 and DETCA via NADPH oxidase downregulation and SOD activation

2013 ◽  
Vol 5 (4) ◽  
pp. 1673-1683 ◽  
Author(s):  
Cristina Perez-Ternero ◽  
Rosalia Rodriguez-Rodriguez ◽  
Juan Parrado ◽  
Maria Alvarez de Sotomayor
Keyword(s):  
Nadph Oxidase ◽  
Vascular Dysfunction ◽  
Grape Pomace ◽  
Enzymatic Extract ◽  
Endothelin 1

NG-monomethyl-L-arginine does not inhibit the hindquarters vasodilator action of endothelin-1 in conscious rats

1989 ◽  
Vol 171 (2-3) ◽  
pp. 237-240 ◽  
Author(s):  
Sheila M. Gardiner ◽  
Alix M. Compton ◽  
Terence Bennett ◽  
Richard M.J. Palmer ◽  
Salvador Moncada
Keyword(s):  
Conscious Rats ◽  
Endothelin 1 ◽  
Vasodilator Action

scholarly journals Endothelin-1 Stimulates Arterial VCAM-1 Expression Via NADPH Oxidase-Derived Superoxide in Mineralocorticoid Hypertension

Hypertension ◽  
2003 ◽  
Vol 42 (5) ◽  
pp. 997-1003 ◽  
Author(s):  
Lixin Li ◽  
Yi Chu ◽  
Gregory D. Fink ◽  
John F. Engelhardt ◽  
Donald D. Heistad ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Endothelin 1

Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC

2009 ◽  
Vol 202 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Miguel Romero ◽  
Rosario Jiménez ◽  
Manuel Sánchez ◽  
Rocío López-Sepúlveda ◽  
Maria José Zarzuelo ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Superoxide Production ◽  
Endothelin 1

scholarly journals Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97007 ◽  
Author(s):  
Hima C. S. Abeysinghe ◽  
Laita Bokhari ◽  
Gregory J. Dusting ◽  
Carli L. Roulston
Keyword(s):  
Conscious Rats ◽  
Endothelin 1
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