scholarly journals Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction

2008 ◽  
Vol 86 (11) ◽  
pp. 2423-2431 ◽  
Author(s):  
Xiaoguang Zhang ◽  
Hsin-Mei Chen ◽  
Eduardo Jaramillo ◽  
Lulu Wang ◽  
Santosh R. D'Mello
Keyword(s):  
Cell Death ◽  
Histone Deacetylase ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Direct Interaction ◽  
Related Protein

Histone Deacetylase 6 Inhibition Attenuates Neuronal Cell Death after Oxygen-Glucose Deprivation and Reoxygenation

2016 ◽  
Vol 223 (4) ◽  
pp. S82 ◽  
Author(s):  
Vahagn C. Nikolian ◽  
Peter J. Bruhn ◽  
Patrick E. Georgoff ◽  
Ihab Halaweish ◽  
Baihong Pan ◽  
...  
Keyword(s):  
Cell Death ◽  
Histone Deacetylase ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Histone Deacetylase 6

SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death

2012 ◽  
Vol 33 (6) ◽  
pp. 1110-1120 ◽  
Author(s):  
Jae-Suk Seo ◽  
Myung-Hee Moon ◽  
Jae-Kyo Jeong ◽  
Jae-Won Seol ◽  
You-Jin Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Histone Deacetylase ◽  
Prion Protein ◽  
Neuronal Cell Death ◽  
Neuronal Cell

Chrysophanol Suppressed Glutamate-Induced Hippocampal Neuronal Cell Death via Regulation of Dynamin-Related Protein 1-Dependent Mitochondrial Fission

Pharmacology ◽  
2017 ◽  
Vol 100 (3-4) ◽  
pp. 153-160 ◽  
Author(s):  
Unbin Chae ◽  
Ju-Sik Min ◽  
Hyun Hee Leem ◽  
Hyun-Shik Lee ◽  
Hong Jun Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Mitochondrial Fission ◽  
Neuronal Cell Death ◽  
Reactive Oxygen Species Generation ◽  
Neuronal Cell ◽  
Long Term Memory ◽  
Related Protein ◽  
Neuronal Function ◽  
Short And Long Term

Chrysophanic acid, or chrysophanol, is an anthraquinone found in Rheum palmatum, which was used in the preparation of oriental medicine in ancient China. The hippocampus plays a major role in controlling the activities of the short- and long-term memory. It is one of the major regions affected by excessive cell death in Alzheimer's disease. Therefore, neuronal cell-death modulation in the hippocampus is important for maintaining neuronal function. We investigated chrysophanol's effects on glutamate-induced hippocampal neuronal cell death. Chrysophanol reduced glutamate-induced cell death via suppression of proapoptotic factors and reactive oxygen species generation. Furthermore, it downregulated glutamate-induced mitochondrial fission by inhibiting dynamin-related protein 1 (Drp1) dephosphorylation. Thus, chrysophanol suppressed hippocampal neuronal cell death via inhibition of Drp1-dependent mitochondrial fission, and can be used as a therapeutic agent for treating neuronal cell death-mediated neurodegenerative diseases.

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