Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex

2008 ◽  
Vol 86 (3) ◽  
pp. 683-693 ◽  
Author(s):  
Guilhian Leipnitz ◽  
Bianca Seminotti ◽  
Josué Haubrich ◽  
Manuela B. Dalcin ◽  
Karina B. Dalcin ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Oxidative Damage ◽  
Rat Cerebral Cortex ◽  
Antioxidant Defenses

Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats

2010 ◽  
Vol 25 (2) ◽  
pp. 145-154 ◽  
Author(s):  
Carolina Didonet Pederzolli ◽  
Caroline Paula Mescka ◽  
Bernardo Remuzzi Zandoná ◽  
Daniella de Moura Coelho ◽  
Ângela Malysz Sgaravatti ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Oxidative Damage ◽  
Antioxidant Defenses ◽  
Acute Administration ◽  
Young Rats

Oxidative Damage of Rat Cerebral Cortex and Hippocampus, and Changes in Antioxidative Defense Systems Caused by Hyperoxia

2003 ◽  
Vol 37 (4) ◽  
pp. 367-372 ◽  
Author(s):  
Koji Onodera ◽  
Nao-Omi Omoi ◽  
Koji Fukui ◽  
Takahiro Hayasaka ◽  
Tadashi Shinkai ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Oxidative Damage ◽  
Rat Cerebral Cortex ◽  
Antioxidative Defense ◽  
Defense Systems

scholarly journals High-Sugar Diet Disrupts Hypothalamic but Not Cerebral Cortex Redox Homeostasis

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3181
Author(s):  
Ewa Żebrowska ◽  
Adrian Chabowski ◽  
Anna Zalewska ◽  
Mateusz Maciejczyk
Keyword(s):  
Cerebral Cortex ◽  
Oxidative Damage ◽  
Redox Homeostasis ◽  
Protein Glycation ◽  
Antioxidant Defenses ◽  
Antioxidant Systems ◽  
Enzymatic Antioxidants ◽  
High Sugar ◽  
Central Plasma ◽  
The Brain

Despite several reports on the relationship between metabolic and neurodegenerative diseases, the effect of a high-sugar diet (HSD) on brain function is still unknown. Given the crucial role of oxidative stress in the pathogenesis of these disorders, this study was the first to compare the effect of an HSD on the activity of prooxidative enzymes, enzymatic and non-enzymatic antioxidants, and protein oxidative damage in the brain structures regulating energy metabolism (hypothalamus) and cognitive functions (cerebral cortex). Male Wistar rats were randomly divided into two groups (n = 10)—control diet (CD) and high-sugar diet (HSD)—for 8 weeks. We showed a decrease in glutathione peroxidase and superoxide dismutase activity and an increase in catalase activity in the hypothalamus of HSD rats compared to controls. The activity of xanthine oxidase and NADPH oxidase and the contents of oxidation (protein carbonyls), glycoxidation (dityrosine, kynurenine and N-formylkynurenine) and protein glycation products (advanced glycation end products and Amadori products) were significantly higher only in the hypothalamus of the study group. The HSD was also responsible for the disruption of antioxidant systems and oxidative damage to blood proteins, but we did not show any correlation between systemic redox homeostasis and the brain levels. In summary, HSD is responsible for disorders of enzymatic antioxidant defenses only at the central (plasma/serum) and hypothalamic levels but does not affect the cerebral cortex. The hypothalamus is much more sensitive to oxidative damage caused by an HSD than the cerebral cortex.

scholarly journals Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats

Life Sciences ◽  
2010 ◽  
Vol 87 (9-10) ◽  
pp. 275-280 ◽  
Author(s):  
Guilhian Leipnitz ◽  
Alexandre U. Amaral ◽  
Ângela Zanatta ◽  
Bianca Seminotti ◽  
Carolina G. Fernandes ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Oxidative Damage ◽  
Phytanic Acid ◽  
Antioxidant Defenses

Vagus Nerve Stimulation Induced Synchrony Modulation of Local Field Potential in the Rat Cerebral Cortex

2013 ◽  
Vol 133 (8) ◽  
pp. 1493-1500 ◽  
Author(s):  
Ryuji Kano ◽  
Kenichi Usami ◽  
Takahiro Noda ◽  
Tomoyo I. Shiramatsu ◽  
Ryohei Kanzaki ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Vagus Nerve ◽  
Local Field ◽  
Nerve Stimulation ◽  
Local Field Potential ◽  
Vagus Nerve Stimulation ◽  
Field Potential ◽  
Rat Cerebral Cortex

Features of Histostructural Changes in Rat Cerebral Cortex in Hemorrhagic Stroke Modeling

2013 ◽  
Vol 4 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Sergiy I. Savosko ◽  
Juriy B. Chaikovsky ◽  
Nelly Kh. Pogorela ◽  
Alexandr N. Makarenko
Keyword(s):  
Cerebral Cortex ◽  
Hemorrhagic Stroke ◽  
Rat Cerebral Cortex

scholarly journals Adenyl Cyclase of Rat Cerebral Cortex

1971 ◽  
Vol 246 (1) ◽  
pp. 62-68 ◽  
Author(s):  
John P. Perkins ◽  
Marilyn M. Moore
Keyword(s):  
Cerebral Cortex ◽  
Adenyl Cyclase ◽  
Rat Cerebral Cortex

scholarly journals Differential assembly of coexpressed glutamate receptor subunits in neurons of rat cerebral cortex

1994 ◽  
Vol 269 (24) ◽  
pp. 16780-16784
Author(s):  
N. Brose ◽  
G.W. Huntley ◽  
Y. Stern-Bach ◽  
G. Sharma ◽  
J.H. Morrison ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Glutamate Receptor ◽  
Rat Cerebral Cortex
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