Protective effect of prion protein via the N-terminal region in mediating a protective effect on paraquat-induced oxidative injury in neuronal cells

2008 ◽  
Vol 86 (3) ◽  
pp. 653-659 ◽  
Author(s):  
Ingrid Dupiereux ◽  
Nandini Falisse-Poirrier ◽  
Willy Zorzi ◽  
Nicole T. Watt ◽  
Olivier Thellin ◽  
...  
Keyword(s):  
Protective Effect ◽  
Prion Protein ◽  
Neuronal Cells ◽  
Oxidative Injury ◽  
Terminal Region

Protective effect of nicotinamide on neuronal cells under oxygen and glucose deprivation and hypoxia/reoxygenation

2004 ◽  
Vol 11 (4) ◽  
pp. 472-481 ◽  
Author(s):  
Chiung-Chyi Shen ◽  
Hsueh-Meei Huang ◽  
Hsiu-Chung Ou ◽  
Huan-Lian Chen ◽  
Wen-Chi Chen ◽  
...  
Keyword(s):  
Protective Effect ◽  
Neuronal Cells ◽  
Glucose Deprivation ◽  
Oxygen And Glucose Deprivation ◽  
Hypoxia Reoxygenation

ChemInform Abstract: Pontemazines A and B, Phenazine Derivatives Containing a Methylamine Linkage from Streptomyces sp. UT1123 and Their Protective Effect to HT-22 Neuronal Cells.

ChemInform ◽  
2016 ◽  
Vol 47 (10) ◽  
pp. no-no
Author(s):  
Jin Wook Cha ◽  
Seung Il Lee ◽  
Min Cheol Kim ◽  
Mya Thida ◽  
Jae Wook Lee ◽  
...  
Keyword(s):  
Protective Effect ◽  
Neuronal Cells ◽  
Streptomyces Sp

scholarly journals Protective Effect of Carnosine Against Zn-Mediated Toxicity in Cortical Neuronal Cells

2007 ◽  
Vol 23 (1) ◽  
pp. 33-38
Author(s):  
Jin-Joo Hue ◽  
Ah-Ram Lee ◽  
Yea-Eun Lee ◽  
Min-Hang Cho ◽  
Ki-Nam Lee ◽  
...  
Keyword(s):  
Protective Effect ◽  
Neuronal Cells

Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice

2018 ◽  
Vol 32 (12) ◽  
pp. 2480-2486 ◽  
Author(s):  
Yuan Li ◽  
Suming Fu ◽  
Enlai Li ◽  
Xianchao Sun ◽  
Haie Xu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Oxidative Injury

The Protective Effect of Picroside II on Isoflurane-Induced Neuronal Injury in Rats via Downregulating miR-195

2021 ◽  
pp. 1-9
Author(s):  
Hui Li ◽  
Weijia Du ◽  
Yawei Yuan ◽  
Jingjing Xue ◽  
Qiang Li ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Protective Effect ◽  
Inflammatory Cytokines ◽  
Escape Latency ◽  
Neuronal Cells ◽  
Neuronal Injury ◽  
Morris Water Maze Test ◽  
Picroside Ii ◽  
Tnf Α ◽  
Pro Inflammatory Cytokines

<b><i>Introduction:</i></b> Numerous pieces of evidence demonstrated that isoflurane induces hippocampal cell injury and cognitive impairments. Picroside II has been investigated for its anti-apoptosis and antioxidant neuroprotective effects. We aimed to explore the protective effects of picroside II and the role of microRNA-195 (miR-195) on isoflurane-induced neuronal injury in rats. <b><i>Methods:</i></b> The Morris water maze test was used to evaluate the effects of isoflurane on rats regarding escape latency and time in quadrant parameters. Real-time quantitative PCR was used to detect the expression levels of miR-195 and pro-inflammatory cytokines, including inter­leukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) mRNA, in the hippocampal tissues and neuronal cells. <b><i>Results:</i></b> The picroside II significantly improves isoflurane-induced higher escape latency and lower time spent in the quadrant compared with the control rats. Picroside II also promotes cell viability and suppresses cell apoptosis of isoflurane-induced neuronal cells. Besides, picroside II suppresses the expression of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and miR-195 in vivo and in vitro. Furthermore, overexpression of miR-195 abrogates the effects of picroside II on the expression of pro-inflammatory cytokines. The appropriate dose of picroside II is 20 mg/kg. <b><i>Conclusion:</i></b> Picroside II could protect the nervous system possibly through inhibiting the inflammatory response in the isoflurane-induced neuronal injury of rats. The protective effect of picroside II may be achieved by downregulating the expression of miR-195 and then inhibiting the inflammatory response.

Protective effect of white tea extract against acute oxidative injury caused by adriamycin in different tissues

2012 ◽  
Vol 134 (4) ◽  
pp. 1780-1785 ◽  
Author(s):  
Cristóbal Espinosa ◽  
José Ángel López-Jiménez ◽  
Lorena Cabrera ◽  
Elvira Larqué ◽  
María Pilar Almajano ◽  
...  
Keyword(s):  
Protective Effect ◽  
Oxidative Injury ◽  
White Tea ◽  
Tea Extract ◽  
Different Tissues
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