Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells

2008 ◽  
Vol 86 (1) ◽  
pp. 48-60 ◽  
Author(s):  
Ichiro Nakano ◽  
Michael Masterman-Smith ◽  
Kuniyasu Saigusa ◽  
Andres A. Paucar ◽  
Steve Horvath ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Brain Tumors ◽  
Leucine Zipper ◽  
Tumor Stem Cells ◽  
Malignant Brain Tumors ◽  
Brain Tumor Stem Cells

scholarly journals Targeting Self-Renewal in High-Grade Brain Tumors Leads to Loss of Brain Tumor Stem Cells and Prolonged Survival

2014 ◽  
Vol 15 (2) ◽  
pp. 185-198 ◽  
Author(s):  
Zhe Zhu ◽  
Muhammad Amir Khan ◽  
Markus Weiler ◽  
Jonas Blaes ◽  
Leonie Jestaedt ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Brain Tumors ◽  
Prolonged Survival ◽  
High Grade ◽  
Tumor Stem Cells ◽  
Self Renewal ◽  
Brain Tumor Stem Cells

Flow Cytometric Analysis of Brain Tumor Stem Cells

2018 ◽  
pp. 69-77
Author(s):  
Minomi K. Subapanditha ◽  
Ashley A. Adile ◽  
Chitra Venugopal ◽  
Sheila K. Singh
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Flow Cytometric Analysis ◽  
Tumor Stem Cells ◽  
Flow Cytometric ◽  
Brain Tumor Stem Cells

Brain Tumor Stem Cells

2014 ◽  
pp. 23-34
Author(s):  
N. Sumru Bayin ◽  
Aram S. Modrek ◽  
Dimitris G. Placantonakis
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Tumor Stem Cells ◽  
Brain Tumor Stem Cells

Brain Tumor Stem Cells

2009 ◽  
pp. 241-259 ◽  
Author(s):  
Christian Nern ◽  
Daniel Sommerlad ◽  
Till Acker ◽  
Karl H. Plate
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Tumor Stem Cells ◽  
Brain Tumor Stem Cells

Brain Tumor Stem Cells

2009 ◽  
Vol 34 (12) ◽  
pp. 2055-2066 ◽  
Author(s):  
Zhigang Xie
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Tumor Stem Cells ◽  
Brain Tumor Stem Cells

scholarly journals Overlapping migratory mechanisms between neural progenitor cells and brain tumor stem cells

2019 ◽  
Vol 76 (18) ◽  
pp. 3553-3570 ◽  
Author(s):  
Natanael Zarco ◽  
Emily Norton ◽  
Alfredo Quiñones-Hinojosa ◽  
Hugo Guerrero-Cázares
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Tumor Stem Cells ◽  
Brain Tumor Stem Cells

scholarly journals TMIC-56. ROLE OF HUMAN BRAIN TUMOR STEM CELLS-DERIVED EXTRACELLULAR VESICLES ON THE PHENOTYPIC TRANSDIFFERENTIATION OF HUMAN NEURAL PROGENITOR CELLS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi260-vi260
Author(s):  
Natanael Zarco ◽  
Emily Norton ◽  
Montserrat Lara-Velazquez ◽  
Anna Carrano ◽  
Alfredo Quinones-Hinojosa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Tumor Microenvironment ◽  
Extracellular Vesicles ◽  
Primary Cultures ◽  
Adult Brain ◽  
Cell Subpopulation ◽  
Tumor Stem Cells ◽  
Brain Tumor Stem Cells

Abstract Glioblastoma (GBM) is the most aggressive of all the brain tumors with a median patient survival less than 15 months. Despite of surgical resection, radiotherapy, and chemotherapy, recurrence rate is almost 100%. A great percentage of GBM tumors (~60%) infiltrate and contact the ventricular-subventricular zone (V-SVZ). Interestingly, these tumors are the most aggressive, and invariably lead to higher distal recurrence rates, shorter time to tumor progression, and lower overall survival of the patient. The reason for this role of V-SVZ-proximity on the outcome of GBM patients is unknown. We suggest that a potential explanation is the interaction of GBM with the V-SVZ. This region is the largest neurogenic niche in the adult brain where neural stem cells (NSCs) give rise to newborn neuroblasts that migrate toward the olfactory bulb. In GBM there is a cell subpopulation called brain tumor stem cells (BTSCs) with NSCs-like characteristics, but with added potential for tumor initiation, recurrence and invasiveness. Tumor microenvironment plays an important role in migration and invasion process. In the present work, we used the total exosome isolation kit to purify Extracellular Vesicles (EVs) from human primary cultures of BTSCs. We determined that BTSCs-derived EVs contain specific information that is transfer to primary cultures of human Neural Progenitors Cells (NPCs) modulating their proliferation rate, cell viability, and migration. In addition, we identify that NPCs taken up BTSCs-derived EVs and significantly increase the expression levels of stemness-related genes such as Nestin, Nanog, and Sox2, suggesting that a phenotypic transdifferentiation is being carry out. These results support our hypothesis that GBM modulate the tumor microenvironment close to the V-SVZ by releasing EVs that target cellular components in this region and promote their phenotypic transformation, highlighting that NPCs biology changes in the context of tumor environment.

Sign in / Sign up

Export Citation Format

Share Document