Progressive oxidative damage in the central nervous system of a murine model for juvenile Batten disease

2007 ◽  
Vol 85 (13) ◽  
pp. 2882-2891 ◽  
Author(s):  
Jared W. Benedict ◽  
Crosby A. Sommers ◽  
David A. Pearce
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Oxidative Damage ◽  
Murine Model ◽  
Batten Disease ◽  
The Central Nervous System ◽  
Juvenile Batten Disease

Oxidation of Potassium Channels in Neurodegenerative Diseases: A Mini- Review

2018 ◽  
Vol 17 (4) ◽  
pp. 267-271 ◽  
Author(s):  
Junsheng Yang ◽  
Xueni Yan
Keyword(s):  
Reactive Oxygen Species ◽  
Central Nervous System ◽  
Nervous System ◽  
Potassium Channels ◽  
Oxidative Damage ◽  
Neurodegenerative Diseases ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cell Functions ◽  
The Central Nervous System

Background & Objective: Increased level of reactive oxygen species is a hallmark of common neurodegenerative diseases such as Alzheimer’s Disease and Parkinson’s Disease. ROS can oxidize macromolecules including DNA, lipids and proteins and cause oxidative damage to the cell. Emerging evidence indicate that potassium channels in the central nervous system are no exceptions to these oxidative modifications. Conclusion: In this mini-review, we summarized recent reports on the oxidation of potassium channels in the CNS and the consequently resulted changes in cell functions and viability, with focus on its implications in neurodegenerative diseases.

scholarly journals Murine Model to Study the Invasion and Survival ofMycobacterium tuberculosisin the Central Nervous System

2008 ◽  
Vol 198 (10) ◽  
pp. 1520-1528 ◽  
Author(s):  
Nicholas A. Be ◽  
Gyanu Lamichhane ◽  
Jacques Grosset ◽  
Sandeep Tyagi ◽  
Qi‐Jian Cheng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Murine Model ◽  
The Central Nervous System

Pharmacokinetics of bendamustine in the central nervous system: chemoinformatic screening followed by validation in a murine model

MedChemComm ◽  
2012 ◽  
Vol 3 (12) ◽  
pp. 1526 ◽  
Author(s):  
Zhimin Li ◽  
Thomas Caulfield ◽  
Yushi Qiu ◽  
John A. Copland ◽  
Han W. Tun
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Murine Model ◽  
The Central Nervous System
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