Alpha-7 nicotinic acetylcholine receptor agonists selectively activate limbic regions of the rat forebrain: An effect similar to antipsychotics

2007 ◽  
Vol 85 (8) ◽  
pp. 1810-1818 ◽  
Author(s):  
Henrik H. Hansen ◽  
Daniel B. Timmermann ◽  
Dan Peters ◽  
Carrie Walters ◽  
M. Imad Damaj ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Nicotinic Acetylcholine ◽  
Receptor Agonists ◽  
Rat Forebrain ◽  
Alpha 7 ◽  
Limbic Regions

scholarly journals Cognitive Enhancers in Schizophrenia: A Systematic Review and Meta-Analysis of Alpha-7 Nicotinic Acetylcholine Receptor Agonists for Cognitive Deficits and Negative Symptoms

2021 ◽  
Vol 12 ◽  
Author(s):  
María Recio-Barbero ◽  
Rafael Segarra ◽  
Arantzazu Zabala ◽  
Eduardo González-Fraile ◽  
Ana González-Pinto ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Negative Symptoms ◽  
Antipsychotic Treatment ◽  
Controlled Trials ◽  
Nicotinic Acetylcholine ◽  
Cognitive Domains ◽  
Receptor Agonists ◽  
Α7 Nachr ◽  
Alpha 7

Background: Schizophrenia is a severe and enduring disease and is one of the leading causes of disability worldwide. Cognitive impairment is a core clinical symptom that plays a crucial role in functional outcomes and prognosis, thus making it a relevant treatment target. The aim of this study was to assess the efficacy of alpha-7 nicotinic acetylcholine receptor agonists (α7 nAChR) as adjunctive treatment to enhance cognition and ameliorate negative symptoms in patients with schizophrenia.Methods: A search strategy was developed for MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials up to May 2019. We included randomized controlled trials (RCTs) that compared antipsychotic treatment plus α7 nAChR agonists with antipsychotic treatment plus placebo and determined their effects on the main cognitive domains proposed by the MATRICS initiative and on negative symptoms. Two authors independently reviewed study eligibility and data extraction and assessed the risk of bias of the studies included. According to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework, we used a random-effects model and assessed the quality of the evidence.Results: Thirteen studies were included in the quantitative analysis. No differences were found in any of the cognitive domains assessed in four RCTs (n = 414). In contrast, nine RCTs (n = 978) presented a small effect in support of α7 nAChR agonists for negative symptoms [standardized mean difference −0.28, 95% CI (−0.56 to −0.00); P = 0.05], even though the confidence to support this evidence is low according to the GRADE system.Conclusions: Current evidence is too weak to consider α7 nAChR agonists as an effective add-on treatment to antipsychotics to enhance cognition and negative symptoms.

Chapter 15. Identification of α7 Nicotinic Acetylcholine Receptor Agonists for their Assessment in Improving Cognition in Schizophrenia

2010 ◽  
pp. 332-362 ◽  
Author(s):  
Bruce N. Rogers ◽  
E. Jon Jacobsen ◽  
Christopher J. O’Donnell ◽  
Christopher L. Shaffer ◽  
Daniel P. Walker ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Nicotinic Acetylcholine ◽  
Receptor Agonists

scholarly journals Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis

2010 ◽  
Vol 160 (2) ◽  
pp. 322-333 ◽  
Author(s):  
Susanne A Snoek ◽  
Marleen I Verstege ◽  
Esmerij P van der Zanden ◽  
Nigel Deeks ◽  
David C Bulmer ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Experimental Colitis ◽  
Α7 Nicotinic Acetylcholine Receptor ◽  
Nicotinic Acetylcholine ◽  
Receptor Agonists
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