In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133

2007 ◽  
Vol 85 (2) ◽  
pp. 250-259 ◽  
Author(s):  
Perrine Barraud ◽  
Simon Stott ◽  
Kjeld Møllgård ◽  
Malin Parmar ◽  
Anders Björklund
Keyword(s):  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
In Vitro Characterization ◽  
Human Neural Progenitor Cell

scholarly journals Front Cover: In Vitro and In Vivo Proteomic Comparison of Human Neural Progenitor Cell‐Induced Photoreceptor Survival

PROTEOMICS ◽  
2019 ◽  
Vol 19 (3) ◽  
pp. 1970011
Author(s):  
Melissa K. Jones ◽  
Bin Lu ◽  
Dawn Zhaohui Chen ◽  
Weston R. Spivia ◽  
Augustus T. Mercado ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Front Cover ◽  
Human Neural Progenitor Cell

scholarly journals Quantitative and kinetic profile of Wnt/β-catenin signaling components during human neural progenitor cell differentiation

2011 ◽  
Vol 16 (4) ◽  
Author(s):  
Orianne Mazemondet ◽  
Rayk Hubner ◽  
Jana Frahm ◽  
Dirk Koczan ◽  
Benjamin Bader ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Progenitor Cell ◽  
Target Genes ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Signaling Molecules ◽  
Human Neural Progenitor Cell ◽  
Wnt Ligands ◽  
Spatio Temporal

AbstractReNcell VM is an immortalized human neural progenitor cell line with the ability to differentiate in vitro into astrocytes and neurons, in which the Wnt/β-catenin pathway is known to be involved. However, little is known about kinetic changes of this pathway in human neural progenitor cell differentiation. In the present study, we provide a quantitative profile of Wnt/β-catenin pathway dynamics showing its spatio-temporal regulation during ReNcell VM cell differentiation. We show first that T-cell factor dependent transcription can be activated by stabilized β-catenin. Furthermore, endogenous Wnt ligands, pathway receptors and signaling molecules are temporally controlled, demonstrating changes related to differentiation stages. During the first three hours of differentiation the signaling molecules LRP6, Dvl2 and β-catenin are spatio-temporally regulated between distinct cellular compartments. From 24 h onward, components of the Wnt/β-catenin pathway are strongly activated and regulated as shown by mRNA up-regulation of Wnt ligands (Wnt5a and Wnt7a), receptors including Frizzled-2, -3, -6, -7, and -9, and co-receptors, and target genes including Axin2. This detailed temporal profile of the Wnt/β-catenin pathway is a first step to understand, control and to orientate, in vitro, human neural progenitor cell differentiation.

scholarly journals In Vitro and In Vivo Proteomic Comparison of Human Neural Progenitor Cell‐Induced Photoreceptor Survival

PROTEOMICS ◽  
2019 ◽  
Vol 19 (3) ◽  
pp. 1800213
Author(s):  
Melissa K. Jones ◽  
Bin Lu ◽  
Dawn Zhaohui Chen ◽  
Weston R. Spivia ◽  
Augustus T. Mercado ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Human Neural Progenitor Cell

scholarly journals Differentiation of human neural progenitor cell-derived spiral ganglion-like neurons: a time-lapse video study

2014 ◽  
Vol 134 (5) ◽  
pp. 441-447 ◽  
Author(s):  
Fredrik Edin ◽  
Wei Liu ◽  
Marja Boström ◽  
Peetra U. Magnusson ◽  
Helge Rask-Andersen
Keyword(s):  
Progenitor Cell ◽  
Spiral Ganglion ◽  
Time Lapse ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Video Study ◽  
Human Neural Progenitor Cell ◽  
Time Lapse Video
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