Role of potassium channels in Aβ1–40-activated apoptotic pathway in cultured cortical neurons

2006 ◽  
Vol 84 (7) ◽  
pp. 1475-1484 ◽  
Author(s):  
Hai-bo Yu ◽  
Zheng-bin Li ◽  
Hai-xia Zhang ◽  
Xiao-liang Wang
Keyword(s):  
Potassium Channels ◽  
Cortical Neurons ◽  
Apoptotic Pathway ◽  
Cultured Cortical Neurons

scholarly journals Critical role of large-conductance calcium- and voltage-activated potassium channels in leptin-induced neuroprotection of N-methyl-d-aspartate-exposed cortical neurons

2014 ◽  
Vol 87 ◽  
pp. 80-86 ◽  
Author(s):  
Maria Mancini ◽  
Maria Virginia Soldovieri ◽  
Guido Gessner ◽  
Bianka Wissuwa ◽  
Vincenzo Barrese ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Cortical Neurons ◽  
Critical Role

P3-077: Protective role of n-trans-feruloyltyramine against beta-amyloid-peptide-induced neurotoxicity, bax, caspase and ROS in rat-cultured cortical neurons

2012 ◽  
Vol 8 (4S_Part_13) ◽  
pp. P479-P480
Author(s):  
Wipawan Thangnipon ◽  
Nirut Suwanna ◽  
Narisorn Kitiyanant ◽  
Rungtip Soi-ampornkul ◽  
Bamroong Munyoo ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Beta Amyloid ◽  
Protective Role ◽  
Amyloid Peptide ◽  
Beta Amyloid Peptide ◽  
Cultured Cortical Neurons

scholarly journals Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis

2006 ◽  
Vol 175 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Yinghua Ma ◽  
Jianxue Li ◽  
Isaac Chiu ◽  
Yawen Wang ◽  
Jacob A. Sloane ◽  
...  
Keyword(s):  
Immune Responses ◽  
Neurite Outgrowth ◽  
Cortical Neurons ◽  
Neuronal Apoptosis ◽  
Negative Regulator ◽  
Toll Like Receptor ◽  
Neuronal Responses ◽  
Adaptive Immune ◽  
Cultured Cortical Neurons

Toll receptors in Drosophila melanogaster function in morphogenesis and host defense. Mammalian orthologues of Toll, the Toll-like receptors (TLRs), have been studied extensively for their essential functions in controlling innate and adaptive immune responses. We report that TLR8 is dynamically expressed during mouse brain development and localizes to neurons and axons. Agonist stimulation of TLR8 in cultured cortical neurons causes inhibition of neurite outgrowth and induces apoptosis in a dissociable manner. Our evidence indicates that such TLR8-mediated neuronal responses do not involve the canonical TLR–NF-κB signaling pathway. These findings reveal novel functions for TLR8 in the mammalian nervous system that are distinct from the classical role of TLRs in immunity.

scholarly journals Role of the Outward Delayed Rectifier K+ Current in Ceramide-Induced Caspase Activation and Apoptosis in Cultured Cortical Neurons

2001 ◽  
Vol 73 (3) ◽  
pp. 933-941 ◽  
Author(s):  
Shan Ping Yu ◽  
Chen-Hsiung Yeh ◽  
Frank Gottron ◽  
Xin Wang ◽  
Margaret C. Grabb ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Delayed Rectifier ◽  
Caspase Activation ◽  
Cultured Cortical Neurons ◽  
K Current

γ-Aminobutyric acid increases intracellular Ca2+ concentration in cultured cortical neurons: role of Cl− transport

1996 ◽  
Vol 297 (1-2) ◽  
pp. 137-143 ◽  
Author(s):  
Minoru Takebayashi ◽  
Ariyuki Kagaya ◽  
Teruo Hayashi ◽  
Nobutaka Motohashi ◽  
Shigeto Yamawaki
Keyword(s):  
Cortical Neurons ◽  
Aminobutyric Acid ◽  
Cl Transport ◽  
Cultured Cortical Neurons
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