Novel roles for metallothionein-I + II (MT-I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: Insights from global gene expression profiling in wild-type and MT-I + II knockout mice

2006 ◽  
Vol 84 (7) ◽  
pp. 1452-1474 ◽  
Author(s):  
Milena Penkowa ◽  
Mario Cáceres ◽  
Rehannah Borup ◽  
Finn Cilius Nielsen ◽  
Christian Bjørn Poulsen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Knockout Mice ◽  
Expression Profiling ◽  
Global Gene Expression ◽  
Defense Responses ◽  
Wild Type ◽  
Global Gene Expression Profiling ◽  
Tissue Restoration

scholarly journals Global gene expression profiling of wild type andlysCknockoutEscherichia coliW3110

2007 ◽  
Vol 276 (2) ◽  
pp. 202-206 ◽  
Author(s):  
Daniel Yuen-Teh Liu ◽  
Chia-Hsin Liu ◽  
Ming-Tsong Lai ◽  
Hua-Kuo Lin ◽  
Tzong-Hsiung Hseu
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Global Gene Expression ◽  
Wild Type ◽  
Global Gene Expression Profiling

Global gene expression profiling of porcine endometria on Days 12 and 16 of the estrous cycle and pregnancy

2014 ◽  
Vol 82 (6) ◽  
pp. 897-909 ◽  
Author(s):  
Jolanta Kiewisz ◽  
Kamil Krawczynski ◽  
Pawel Lisowski ◽  
Agnieszka Blitek ◽  
Lech Zwierzchowski ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Estrous Cycle ◽  
Expression Profiling ◽  
Global Gene Expression ◽  
Global Gene Expression Profiling

Gene Expression Profiling for Discovery of Novel Targets in Human Traumatic Brain Injury

2010 ◽  
Vol 13 (2) ◽  
pp. 140-153 ◽  
Author(s):  
Taura L. Barr ◽  
Sheila Alexander ◽  
Yvette Conley
Keyword(s):  
Gene Expression ◽  
Traumatic Brain Injury ◽  
Clinical Trials ◽  
Brain Injury ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Treatment Strategies ◽  
Biological Pathways ◽  
Human Response ◽  
Novel Targets

Several clinical trials have failed to demonstrate a significant effect on outcome following human traumatic brain injury (TBI) despite promising results obtained in preclinical animal studies. These failures may be due in part to a misinterpretation of the findings obtained in preclinical animal models of TBI, a misunderstanding of the complexity of the human response to TBI, limited knowledge about the biological pathways that interact to contribute to good and bad outcomes after brain injury, and the effects of genomic variability and environment on individual recovery. Recent publications suggest that data obtained from gene expression profiling studies of complex neurological diseases such as stroke, multiple sclerosis (MS), Alzheimer’s and Parkinson’s may contribute to a more informed understanding of what affects outcome following TBI. These data may help to bridge the gap between successful preclinical studies and negative clinical trials in humans to reveal novel targets for therapy. Gene expression profiling has the capability to identify biomarkers associated with response to TBI, elucidate complex genetic interactions that may play a role in outcome following TBI, and reveal biological pathways related to brain health. This review highlights the current state of the literature on gene expression profiling for neurological disease and discusses its ability to aid in unraveling the variable human response to TBI and the potential for it to offer treatment strategies in an area where we currently have limited therapeutic options primarily based on supportive care.

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