Nicotine prevents stress-induced enhancement of long-term depression in hippocampal area CA1: Electrophysiological and molecular studies

2006 ◽  
Vol 83 (2) ◽  
pp. 309-317 ◽  
Author(s):  
A.M. Aleisa ◽  
K.H. Alzoubi ◽  
K.A. Alkadhi
Keyword(s):  
Long Term Depression ◽  
Area Ca1 ◽  
Molecular Studies ◽  
Hippocampal Area

Chemical Induction of mGluR5- and Protein Synthesis–Dependent Long-Term Depression in Hippocampal Area CA1

2001 ◽  
Vol 86 (1) ◽  
pp. 321-325 ◽  
Author(s):  
Kimberly M. Huber ◽  
John C. Roder ◽  
Mark F. Bear
Keyword(s):  
Protein Synthesis ◽  
Metabotropic Glutamate Receptors ◽  
Chemical Induction ◽  
Long Term Depression ◽  
Metabotropic Glutamate ◽  
Synaptic Modification ◽  
Area Ca1 ◽  
Hippocampal Area ◽  
Expression Mechanism

Recent work has demonstrated that specific patterns of synaptic stimulation can induce long-term depression (LTD) in area CA1 that depends on activation of metabotropic glutamate receptors (mGluRs) and rapid protein synthesis. Here we show that the same form of synaptic modification can be induced by brief application of the selective mGluR agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). DHPG-LTD 1) is a saturable form of synaptic plasticity, 2) requires mGluR5, 3) is mechanistically distinct from N-methyl-d-aspartate receptor (NMDAR)–dependent LTD, and 4) shares a common expression mechanism with protein synthesis–dependent LTD evoked using synaptic stimulation. DHPG-LTD should be useful for biochemical analysis of mGluR5- and protein synthesis–dependent synaptic modification.

Stimulation at 1-5 Hz does not produce long-term depression or depotentiation in the hippocampus of the adult rat in vivo

1995 ◽  
Vol 74 (4) ◽  
pp. 1793-1799 ◽  
Author(s):  
M. L. Errington ◽  
T. V. Bliss ◽  
G. Richter-Levin ◽  
K. Yenk ◽  
V. Doyere ◽  
...  
Keyword(s):  
Young Animal ◽  
Low Frequency ◽  
Long Term Depression ◽  
Developmentally Regulated ◽  
Adult Rats ◽  
Adult Rat ◽  
Area Ca1 ◽  
Awake Rat

1. We examined the efficacy of low-frequency trains (1-5 Hz) in producing long-term depression (LTD) or depotentiation in the hippocampus of the awake adult rat and in anesthetized rats aged from 10 days to 3 mo. 2. In the dentate gyrus we found no evidence that low-frequency trains produce either depotentiation or LTD in the awake, adult animal or in the anesthetized animal at any age tested (10 days-adult). 3. In area CA1 of both awake and anesthetized adult rats, we also found no evidence that low-frequency trains induced either LTD or depotentiation. Only in area CA1 of very young rats (10-11 days) was clear evidence for LTD and depotentiation obtained; at this age experiments were only possible in anesthetized animals. By 16 days, the ability to display both LTD and depotentiation was lost. 4. These experiments suggest that repetitive low-frequency stimulation evokes a developmentally regulated form of activity-dependent depression that in the hippocampus is limited to specific pathways in the young animal. Our results leave open the question of whether alternative patterns of activity can induce LTD and/or depotentiation in the adult awake rat.

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