PI3K/Akt-dependent regulation of the transcription factor myocyte enhancer factor-2 in insulin-like growth factor-1- and membrane depolarization-mediated survival of cerebellar granule neurons

2005 ◽  
Vol 81 (2) ◽  
pp. 226-234 ◽  
Author(s):  
M. Wiedmann ◽  
X. Wang ◽  
X. Tang ◽  
M. Han ◽  
M. Li ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Growth Factor ◽  
Membrane Depolarization ◽  
Cerebellar Granule Neurons ◽  
Granule Neurons ◽  
Insulin Like Growth Factor ◽  
Myocyte Enhancer Factor 2 ◽  
Cerebellar Granule ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor

scholarly journals Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP

1993 ◽  
Vol 90 (23) ◽  
pp. 10989-10993 ◽  
Author(s):  
S R D'Mello ◽  
C Galli ◽  
T Ciotti ◽  
P Calissano
Keyword(s):  
Cell Death ◽  
Nervous System ◽  
Growth Factor ◽  
Cerebellar Granule Neurons ◽  
Granule Neurons ◽  
Insulin Like Growth Factor ◽  
Cerebellar Granule ◽  
Factor I ◽  
Growth Factor I ◽  
Low K

High levels of extracellular K+ ensure proper development and prolong survival of cerebellar granule neurons in culture. We find that when switched from a culture medium containing high K+ (25 mM) to one containing a low but more physiological K+ concentration (5 mM), differentiated granule neurons degenerate and die. Death induced by low K+ is due to apoptosis (programmed cell death), a form of cell death observed extensively in the developing nervous system and believed to be necessary for proper neurogenesis. The death process is accompanied by cleavage of genomic DNA into internucleosome-sized fragments, a hallmark of apoptosis. Inhibitors of transcription and translation suppress apoptosis induced by low K+, suggesting the necessity for newly synthesized gene products for activation of the process. Death can be prevented by insulin-like growth factor I but not by several other growth/neurotrophic factors. cAMP but not the protein kinase C activator phorbol 12-myristate 13-acetate can also support survival in low K+. In view of the large numbers of granule neurons that can be homogeneously cultured, our results offer the prospect of an excellent model system to study the mechanisms underlying apoptosis in the central nervous system and the suppression of this process by survival factors such as insulin-like growth factor I.

scholarly journals Myocyte Enhancer Factor 2A and 2D Undergo Phosphorylation and Caspase-Mediated Degradation during Apoptosis of Rat Cerebellar Granule Neurons

2001 ◽  
Vol 21 (17) ◽  
pp. 6544-6552 ◽  
Author(s):  
Mingtao Li ◽  
Daniel A. Linseman ◽  
Melissa P. Allen ◽  
Mary Kay Meintzer ◽  
Xiaomin Wang ◽  
...  
Keyword(s):  
Cerebellar Granule Neurons ◽  
Granule Neurons ◽  
Cerebellar Granule ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor

Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2

2004 ◽  
Vol 127 (4) ◽  
pp. 1174-1188 ◽  
Author(s):  
Xuemin Wang ◽  
Xiaoli Tang ◽  
Xiaoming Gong ◽  
Efsevia Albanis ◽  
Scott L. Friedman ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Myocyte Enhancer Factor 2 ◽  
Hepatic Stellate Cell Activation ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor
Sign in / Sign up

Export Citation Format

Share Document