Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear

2004 ◽  
Vol 76 (3) ◽  
pp. 296-305 ◽  
Author(s):  
Anand N. Mhatre ◽  
Jiang Li ◽  
Yuil Kim ◽  
Donald E. Coling ◽  
Anil K. Lalwani
Keyword(s):  
Inner Ear ◽  
Developmental Expression ◽  
Nonmuscle Myosin ◽  
Myosin Iia

Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells

2011 ◽  
Vol 1809 (3) ◽  
pp. 176-183 ◽  
Author(s):  
Masayuki Ebina ◽  
Masahiko Shibazaki ◽  
Kyoko Kudo ◽  
Shuya Kasai ◽  
Hideaki Kikuchi
Keyword(s):  
Nonmuscle Myosin ◽  
Myosin Iia

scholarly journals Crystal structure of the S100A4-nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism

2012 ◽  
Vol 109 (16) ◽  
pp. 6048-6053 ◽  
Author(s):  
B. Kiss ◽  
A. Duelli ◽  
L. Radnai ◽  
K. A. Kekesi ◽  
G. Katona ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Binding Mechanism ◽  
Nonmuscle Myosin ◽  
Myosin Iia ◽  
Target Binding

scholarly journals Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion

2017 ◽  
Vol 350 (2) ◽  
pp. 336-348 ◽  
Author(s):  
Anita A. Wasik ◽  
Vincent Dumont ◽  
Jukka Tienari ◽  
Tuula A. Nyman ◽  
Christopher L. Fogarty ◽  
...  
Keyword(s):  
Nonmuscle Myosin ◽  
Vesicle Docking ◽  
Storage Vesicle ◽  
Myosin Iia

Genetics, clinical and pathological features of glomerulonephrites associated with mutations of nonmuscle myosin IIA (Fechtner syndrome)

2003 ◽  
Vol 41 (1) ◽  
pp. 95-104 ◽  
Author(s):  
Gian Marco Ghiggeri ◽  
Gianluca Caridi ◽  
Umberto Magrini ◽  
Adalberto Sessa ◽  
Anna Savoia ◽  
...  
Keyword(s):  
Pathological Features ◽  
Nonmuscle Myosin ◽  
Fechtner Syndrome ◽  
Myosin Iia ◽  
Clinical And Pathological Features

Multilevel Changes in Protein Dynamics upon Complex Formation of the Calcium-Loaded S100A4 with a Nonmuscle Myosin IIA Tail Fragment

ChemBioChem ◽  
2016 ◽  
Vol 17 (19) ◽  
pp. 1829-1838 ◽  
Author(s):  
Gyula Pálfy ◽  
Bence Kiss ◽  
László Nyitray ◽  
Andrea Bodor
Keyword(s):  
Complex Formation ◽  
Protein Dynamics ◽  
Nonmuscle Myosin ◽  
Myosin Iia

scholarly journals ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens

2017 ◽  
Vol 28 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Rashmi Priya ◽  
Xuan Liang ◽  
Jessica L. Teo ◽  
Kinga Duszyc ◽  
Alpha S. Yap ◽  
...  
Keyword(s):  
Catalytic Domain ◽  
Cell Movement ◽  
Kinase Domain ◽  
Small Gtpase ◽  
Major Determinant ◽  
Nonmuscle Myosin ◽  
Cytoskeletal Remodeling ◽  
Myosin Iia ◽  
Rhoa Signaling ◽  
Rho Kinases

Rho kinases (ROCK1 and ROCK2) function downstream of the small GTPase RhoA to drive actomyosin cytoskeletal remodeling. It has often been believed that ROCK1 and ROCK2 may be functionally redundant, as they share a highly conserved kinase domain. However, in this study, we report differential functional effects for these ROCKs at the epithelial zonula adherens (ZA). Using specific siRNA, we found that ROCK1 depletion disrupted cadherin organization at the ZA, accompanied by loss of F-actin and NMIIA, whereas ROCK2 knockdown had no significant effect. Further, ROCK1, but not ROCK2, was necessary to stabilize GTP-RhoA at the ZA, thereby sustaining junctional tension and inhibiting intraepithelial cell movement. We also found that nonmuscle myosin IIA is a major determinant of ROCK1 cortical stability. Thus, despite sharing the catalytic domain with ROCK2, ROCK1 appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.

The effect of mutations in nonmuscle myosin IIA on cell contractility

2017 ◽  
Vol 2017.28 (0) ◽  
pp. 2A24
Author(s):  
Shota P. FUKUDA ◽  
Tsubasa S. MATSUI ◽  
Taichi FURUKAWA ◽  
Shuichiro FUKUSHIMA ◽  
Shinji DEGUCHI
Keyword(s):  
Nonmuscle Myosin ◽  
Cell Contractility ◽  
Myosin Iia

Mts1 Regulates the Assembly of Nonmuscle Myosin-IIA†

Biochemistry ◽  
2003 ◽  
Vol 42 (48) ◽  
pp. 14258-14266 ◽  
Author(s):  
Zhong-Hua Li ◽  
Anna Spektor ◽  
Olga Varlamova ◽  
Anne R. Bresnick
Keyword(s):  
Nonmuscle Myosin ◽  
Myosin Iia
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