Short-term evolution of autoreactive T cell repertoire in multiple sclerosis

2001 ◽  
Vol 66 (3) ◽  
pp. 517-524 ◽  
Author(s):  
M. Vergelli ◽  
B. Mazzanti ◽  
E. Traggiai ◽  
T. Biagioli ◽  
C. Ballerini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
T Cell Repertoire ◽  
Short Term ◽  
Cell Repertoire ◽  
Autoreactive T Cell ◽  
Term Evolution

scholarly journals HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

Cell ◽  
2020 ◽  
Vol 183 (5) ◽  
pp. 1264-1281.e20 ◽  
Author(s):  
Jian Wang ◽  
Ivan Jelcic ◽  
Lena Mühlenbruch ◽  
Veronika Haunerdinger ◽  
Nora C. Toussaint ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Autoreactive T Cell

Myelin basic protein and myelin oligodendrocyte glycoprotein T-cell repertoire in childhood and juvenile multiple sclerosis

2006 ◽  
Vol 12 (4) ◽  
pp. 412-420 ◽  
Author(s):  
Jorge Correale ◽  
Silvia N Tenembaum
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
T Cell Repertoire ◽  
Adult Onset ◽  
Cell Repertoire ◽  
Juvenile Onset ◽  
Exon 2

Multiple sclerosis (MS) is usually a disease of young adulthood, its clinical onset occurring between 20 and 40 years of age; however, today there is general consensus that MS can also occur in children, adolescents and even in infants. In order to gain further insight into the T-cell repertoire present in this particular group of patients myelin basic protein (MBP)-, MBP exon-2- and myelin oligodendrocyte glycoprotein (MOG)Igd-specific T-cell lines (TCLs) were isolated from 18 patients whose symptoms had started before the age of 16. Epitope specificity was established by measuring proliferative responses, and interferon-g (IFN-g) secretion by using a panel of overlapping synthetic peptides. For MOGIgd, the T-cell response was focused on three main immunodominant epitopes comprising residues 1-26, 36-60 and 63-87. For MBP the predominant immune responses were directed against peptides 83-102, 139-153 and 146-162. When compared to those observed in adult-onset MS patients, anti-MOGIgd specificity and anti-MBP responses showed similar results. Moreover, the number of MBP exon-2 TCLs isolated, and the magnitude of the specific IFN-g secretion induced were similar, both in childhood/juvenile-onset and adult-onset MS patients. Thus, despite differences in the clinical and neuroimaging manifestations of MS, these results would seem to indicate that both the spectrum of MBP found, as well as the MOGIgd epitopes recognized by peripheral blood T cells in MS, appear to be similar for childhood/juvenile-onset and adult-onset patients.

scholarly journals T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

Cell Reports ◽  
2019 ◽  
Vol 29 (4) ◽  
pp. 810-815.e4 ◽  
Author(s):  
Caren Ramien ◽  
Erik C. Yusko ◽  
Jan Broder Engler ◽  
Stefanie Gamradt ◽  
Kostas Patas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

10.1038/71540 ◽  
2000 ◽  
Vol 6 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Ludger Klein ◽  
Matthias Klugmann ◽  
Klaus-Armin Nave ◽  
V K Tuohy ◽  
Bruno Kyewski
Keyword(s):  
T Cell ◽  
Epithelial Cells ◽  
Splice Variant ◽  
Thymic Epithelial Cells ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Autoreactive T Cell

Glatiramer acetate (GA) therapy induces a focused, oligoclonal CD8+ T-cell repertoire in multiple sclerosis

2006 ◽  
Vol 180 (1-2) ◽  
pp. 159-171 ◽  
Author(s):  
Brian W. Biegler ◽  
Shirley X. Yan ◽  
Sterling B. Ortega ◽  
Deepani K. Tennakoon ◽  
Michael K. Racke ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Glatiramer Acetate ◽  
Cd8 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire

scholarly journals Characterization of CD8+ T cell repertoire in identical twins discordant and concordant for multiple sclerosis

2006 ◽  
Vol 81 (3) ◽  
pp. 696-710 ◽  
Author(s):  
Paolo Somma ◽  
Giovanni Ristori ◽  
Luca Battistini ◽  
Stefania Cannoni ◽  
Giovanna Borsellino ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Cd8 T Cell ◽  
Identical Twins ◽  
T Cell Repertoire ◽  
Cell Repertoire
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