Identification of aHoxd10-regulated transcriptional network and combinatorial interactions withHoxa10 during spinal cord development

2004 ◽  
Vol 75 (3) ◽  
pp. 307-319 ◽  
Author(s):  
Eva Hedlund ◽  
Stanislav L. Karsten ◽  
Lili Kudo ◽  
Daniel H. Geschwind ◽  
Ellen M. Carpenter
Keyword(s):  
Spinal Cord ◽  
Transcriptional Network ◽  
Spinal Cord Development ◽  
Combinatorial Interactions

An Early Developmental Marker for Radial Glia in Rat Spinal Cord

1996 ◽  
Vol 54 ◽  
pp. 36-37
Author(s):  
V. Kriho ◽  
H.-Y. Yang ◽  
C.-M. Lue ◽  
N. Lieska ◽  
G. D. Pappas
Keyword(s):  
Spinal Cord ◽  
Intermediate Filament ◽  
Radial Glia ◽  
Rat Spinal Cord ◽  
Future Studies ◽  
Spinal Cord Development ◽  
Median Septum ◽  
Differentiation Marker ◽  
Early Developmental ◽  
Developing Rat

Radial glia have been classically defined as those early glial cells that radially span their thin processes from the ventricular to the pial surfaces in the developing central nervous system. These radial glia constitute a transient cell population, disappearing, for the most part, by the end of the period of neuronal migration. Traditionally, it has been difficult to definitively identify these cells because the principal criteria available were morphologic only.Using immunofluorescence microscopy, we have previously defined a phenotype for radial glia in rat spinal cord based upon the sequential expression of vimentin, glial fibrillary acidic protein and an intermediate filament-associated protein, IFAP-70/280kD. We report here the application of another intermediate filament-associated protein, IFAP-300kD, originally identified in BHK-21 cells, to the immunofluorescence study of radial glia in the developing rat spinal cord.Results showed that IFAP-300kD appeared very early in rat spinal cord development. In fact by embryonic day 13, IFAP-300kD immunoreactivity was already at its peak and was observed in most of the radial glia which span the spinal cord from the ventricular to the subpial surfaces (Fig. 1). Interestingly, from this time, IFAP-300kD immunoreactivity diminished rapidly in a dorsal to ventral manner, so that by embryonic day 16 it was detectable only in the maturing macroglial cells in the marginal zone of the spinal cord and the dorsal median septum (Fig. 2). By birth, the spinal cord was essentially immuno-negative for this IFAP. Thus, IFAP-300kD appears to be another differentiation marker available for future studies of gliogenesis, especially for the early stages of radial glia differentiation.

scholarly journals Glycine Release from Radial Cells Modulates the Spontaneous Activity and Its Propagation during Early Spinal Cord Development

2010 ◽  
Vol 30 (1) ◽  
pp. 390-403 ◽  
Author(s):  
A.-L. Scain ◽  
H. Le Corronc ◽  
A.-E. Allain ◽  
E. Muller ◽  
J.-M. Rigo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spontaneous Activity ◽  
Spinal Cord Development ◽  
Glycine Release

scholarly journals Diminished ventral oligodendrocyte precursor generation results in the subsequent over-production of dorsal oligodendrocyte precursors of aberrant morphology and function

2020 ◽  
Author(s):  
Lev Starikov ◽  
Andreas H. Kottmann
Keyword(s):  
Spinal Cord ◽  
Motor Neurons ◽  
Ventricular Zone ◽  
Normal Numbers ◽  
Spinal Cord Development ◽  
Oligodendrocyte Precursor ◽  
And Function ◽  
Sod1 Mouse ◽  
Lateral Sclerosis ◽  
Ventral Spinal Cord

AbstractOligodendrocyte precursor cells (OPCs) arise sequentially first from a ventral and then from a dorsal precursor domain at the end of neurogenesis during spinal cord development. Whether the sequential production of OPCs is of physiological significance has not been examined. Here we show that ablating Shh signaling from nascent ventricular zone derivatives and partially from the floor plate results in a severe diminishment of ventral derived OPCs but normal numbers of motor neurons in the postnatal spinal cord. In the absence of ventral vOPCs, dorsal dOPCs populate the entire spinal cord resulting in an increased OPC density in the ventral horns. These OPCs take on an altered morphology, do not participate in the removal of excitatory vGlut1 synapses from injured motor neurons, and exhibit morphological features similar to those found in the vicinity of motor neurons in the SOD1 mouse model of Amyotrophic Lateral Sclerosis (ALS). Our data indicates that vOPCs prevent dOPCs from invading ventral spinal cord laminae and suggests that vOPCs have a unique ability to communicate with injured motor neurons.

Spinal development and spinal dysraphism

2019 ◽  
pp. 983-992
Author(s):  
Dominic Thompson
Keyword(s):  
Spinal Cord ◽  
Spinal Dysraphism ◽  
Radical Resection ◽  
Management Plan ◽  
Congenital Disorders ◽  
Spinal Cord Development ◽  
Precise Diagnosis ◽  
Over Time ◽  
Spinal Cord Tethering

The term spinal dysraphism encompasses a group of congenital disorders of spinal cord development. This potentially confusing array of conditions is best understood from an embryological perspective, and a unifying method of classification is presented. Spinal dysraphism is associated with neurological, urological, and orthopaedic deficits, these may be present at birth or may evolve over time due to the effects of spinal cord tethering. Precise diagnosis is essential to formulating an appropriate surgical management plan in order to optimize long-term neurological outcome. Contemporary and controversial surgical advances in the field are discussed including electrophysiology directed radical resection for spinal lipomas and antenatal surgery for myelomeningocele.

scholarly journals Cell-Specific Actions of a Human LHX3 Gene Enhancer During Pituitary and Spinal Cord Development

2013 ◽  
Vol 27 (12) ◽  
pp. 2013-2027 ◽  
Author(s):  
Soyoung Park ◽  
Rachel D. Mullen ◽  
Simon J. Rhodes
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Development ◽  
Gene Enhancer

The multiple activities of BMPs during spinal cord development

2013 ◽  
Vol 70 (22) ◽  
pp. 4293-4305 ◽  
Author(s):  
Gwenvael Le Dréau ◽  
Elisa Martí
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Development

scholarly journals ADAM10 Negatively Regulates Neuronal Differentiation during Spinal Cord Development

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e84617 ◽  
Author(s):  
Xin Yan ◽  
Juntang Lin ◽  
Venkata Ajay Narendra Talabattula ◽  
Carolin Mußmann ◽  
Fan Yang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuronal Differentiation ◽  
Spinal Cord Development
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