scholarly journals Blood-spinal cord barrier after spinal cord injury: Relation to revascularization and wound healing

2003 ◽  
Vol 74 (2) ◽  
pp. 227-239 ◽  
Author(s):  
William D. Whetstone ◽  
Jung-Yu C. Hsu ◽  
Manuel Eisenberg ◽  
Zena Werb ◽  
Linda J. Noble-Haeusslein
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Wound Healing ◽  
Cord Injury ◽  
Blood Spinal Cord Barrier

scholarly journals Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christian Blume ◽  
M. F. Geiger ◽  
M. Müller ◽  
H. Clusmann ◽  
V. Mainz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Status ◽  
Consecutive Series ◽  
Inflammatory Reactions ◽  
Immune Mediated ◽  
Elisa Testing ◽  
Cord Injury ◽  
Blood Spinal Cord Barrier ◽  
Angiopoietin 2

AbstractEndogenous immune mediated reactions of inflammation and angiogenesis are components of the spinal cord injury in patients with degenerative cervical myelopathy (DCM). The aim of this study was to identify alteration of certain mediators participating in angiogenetic and inflammatory reactions in patients with DCM. A consecutive series of 42 patients with DCM and indication for surgical decompression were enrolled for the study. 28 DCM patients were included, as CSF samples were taken preoperatively. We enrolled 42 patients requiring surgery for a thoracic abdominal aortic aneurysm (TAAA) as neurologically healthy controls. In 38 TAAA patients, CSF samples were taken prior to surgery and thus included. We evaluated the neurological status of patients and controls prior to surgery including NDI and mJOA. Protein-concentrations of factors with a crucial role in inflammation and angiogenesis were measured in CSF via ELISA testing (pg/ml): Angiopoietin 2, VEGF-A and C, RANTES, IL 1 beta and IL 8. Additionally, evaluated the status of the blood-spinal cord barrier (BSCB) by Reibers´diagnostic in all participants. Groups evidently differed in their neurological status (mJOA: DCM 10.1 ± 3.3, TAAA 17.3 ± 1.2, p < .001; NDI: DCM 47.4 ± 19.7, TAAA 5.3 ± 8.6, p < .001). There were no particular differences in age and gender distribution. However, we detected statistically significant differences in concentrations of mediators between the groups: Angiopoietin 2 (DCM 267.1.4 ± 81.9, TAAA 408.6 ± 177.1, p < .001) and VEGF C (DCM 152.2 ± 96.1, TAAA 222.4 ± 140.3, p = .04). DCM patients presented a mild to moderate BSCB disruption, controls had no signs of impairment. In patients with DCM, we measured decreased concentrations of angiogenic mediators. These results correspond to findings of immune mediated secondary harm in acute spinal cord injury. Reduced angiogenic activity could be a relevant part of the pathogenesis of DCM and secondary harm to the spinal cord.

scholarly journals Spinal Cord Injury Suppresses Cutaneous Inflammation: Implications for Peripheral Wound Healing

2017 ◽  
Vol 34 (6) ◽  
pp. 1149-1155 ◽  
Author(s):  
Jessica M. Marbourg ◽  
Anna Bratasz ◽  
Xiaokui Mo ◽  
Phillip G. Popovich
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Wound Healing ◽  
Cutaneous Inflammation ◽  
Cord Injury

scholarly journals Near-infrared light-triggered NO release for spinal cord injury repair

2020 ◽  
Vol 6 (39) ◽  
pp. eabc3513
Author(s):  
Yaqin Jiang ◽  
Pengfei Fu ◽  
Yanyan Liu ◽  
Chaochao Wang ◽  
Peiran Zhao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Near Infrared ◽  
Nerve Repair ◽  
Infrared Light ◽  
Zeolitic Imidazolate Framework ◽  
No Donor ◽  
Cord Injury ◽  
No Release ◽  
Blood Spinal Cord Barrier

Traumatic spinal cord injury (SCI) is caused by external physical impacts and can induce complex cascade events, sometimes converging to paralysis. Existing clinical drugs to traumatic SCI have limited therapeutic efficacy because of either the poor blood–spinal cord barrier (BSCB) permeability or a single function. Here, we suggest a “pleiotropic messenger” strategy based on near-infrared (NIR)–triggered on-demand NO release at the lesion area for traumatic SCI recovery via the concurrent neuroregeneration and neuroprotection processing. This NO delivery system was constructed as upconversion nanoparticle (UCNP) core coated by zeolitic imidazolate framework–8 (ZIF-8) with NO donor (CysNO). This combined strategy substantial promotes the repair of SCI in vertebrates, ascribable to the pleiotropic effects of NO including the suppression of gliosis and inflammation, the promotion of neuroregeneration, and the protection of neurons from apoptosis, which opens intriguing perspectives not only in nerve repair but also in neurological research and tissue engineering.

Melatonin Treatment Protects Against Acute Spinal Cord Injury-Induced Disruption of Blood Spinal Cord Barrier in Mice

2014 ◽  
Vol 54 (4) ◽  
pp. 714-722 ◽  
Author(s):  
Qingbin Wu ◽  
Yingli Jing ◽  
Xiaochen Yuan ◽  
Xiaoyan Zhang ◽  
Bingwei Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Acute Spinal Cord Injury ◽  
Melatonin Treatment ◽  
Cord Injury ◽  
Blood Spinal Cord Barrier

Propitious Therapeutic Modulators to Prevent Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury

2016 ◽  
Vol 54 (5) ◽  
pp. 3578-3590 ◽  
Author(s):  
Hemant Kumar ◽  
Alexander E. Ropper ◽  
Soo-Hong Lee ◽  
Inbo Han
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Barrier Disruption ◽  
Cord Injury ◽  
Blood Spinal Cord Barrier

Matrix Metalloproteinase-8 Inhibition Prevents Disruption of Blood–Spinal Cord Barrier and Attenuates Inflammation in Rat Model of Spinal Cord Injury

2017 ◽  
Vol 55 (3) ◽  
pp. 2577-2590 ◽  
Author(s):  
Hemant Kumar ◽  
Min-Jae Jo ◽  
Hyemin Choi ◽  
Manjunatha S. Muttigi ◽  
Seil Shon ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Matrix Metalloproteinase ◽  
Rat Model ◽  
Cord Injury ◽  
Blood Spinal Cord Barrier
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