Caspase regulation of genotoxin-induced neural precursor cell death

2003 ◽  
Vol 74 (3) ◽  
pp. 435-445 ◽  
Author(s):  
Cleta D'Sa ◽  
Barbara J. Klocke ◽  
Francesco Cecconi ◽  
Tulia Lindsten ◽  
Craig B. Thompson ◽  
...  
Keyword(s):  
Cell Death ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Caspase Regulation

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3

Development ◽  
2001 ◽  
Vol 128 (1) ◽  
pp. 137-146
Author(s):  
C. D'Sa-Eipper ◽  
J.R. Leonard ◽  
G. Putcha ◽  
T.S. Zheng ◽  
R.A. Flavell ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Cell Apoptosis ◽  
Neuronal Apoptosis ◽  
Caspase 3 ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Normal Brain ◽  
Neural Precursor Cell ◽  
Caspase 9

Programmed cell death (apoptosis) is critical for normal brain morphogenesis and may be triggered by neurotrophic factor deprivation or irreparable DNA damage. Members of the Bcl2 and caspase families regulate neuronal responsiveness to trophic factor withdrawal; however, their involvement in DNA damage-induced neuronal apoptosis is less clear. To define the molecular pathway regulating DNA damage-induced neural precursor cell apoptosis, we have examined the effects of drug and gamma-irradiation-induced DNA damage on telencephalic neural precursor cells derived from wild-type embryos and mice with targeted disruptions of apoptosis-associated genes. We found that DNA damage-induced neural precursor cell apoptosis, both in vitro and in vivo, was critically dependent on p53 and caspase 9, but neither Bax nor caspase 3 expression. Neural precursor cell apoptosis was also unaffected by targeted disruptions of Bclx and Bcl2, and unlike neurotrophic factor-deprivation-induced neuronal apoptosis, was not associated with a detectable loss of cytochrome c from mitochondria. The apoptotic pathway regulating DNA damage-induced neural precursor cell death is different from that required for normal brain morphogenesis, which involves both caspase 9 and caspase 3 but not p53, indicating that additional apoptotic stimuli regulate neural precursor cell numbers during telencephalic development.

scholarly journals bcl-2/Adenovirus E1B 19-kd Interacting Protein 3 (BNIP3) Regulates Hypoxia-Induced Neural Precursor Cell Death

2009 ◽  
Vol 68 (12) ◽  
pp. 1326-1338 ◽  
Author(s):  
K.C. Walls ◽  
Arindam P. Ghosh ◽  
Mary E. Ballestas ◽  
Barbara J. Klocke ◽  
Kevin A. Roth
Keyword(s):  
Cell Death ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Interacting Protein ◽  
Adenovirus E1b

scholarly journals BH3-Only Proapoptotic Bcl-2 Family Members Noxa and Puma Mediate Neural Precursor Cell Death

2006 ◽  
Vol 26 (27) ◽  
pp. 7257-7264 ◽  
Author(s):  
R. S. Akhtar ◽  
Y. Geng ◽  
B. J. Klocke ◽  
C. B. Latham ◽  
A. Villunger ◽  
...  
Keyword(s):  
Cell Death ◽  
Family Members ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

scholarly journals p53 Regulation of Neural Precursor Cell Death

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Ying Geng ◽  
Rizwan Akhtar ◽  
Barbara Klocke ◽  
Kevin Roth
Keyword(s):  
Cell Death ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

scholarly journals Differential p53 Regulation of Neural Precursor Cell Death

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Ying Geng ◽  
Rizwan S. Akhtar ◽  
Kevin A. Roth
Keyword(s):  
Cell Death ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

A Review of Bioreactor Protocols for Human Neural Precursor Cell Expansion in Preparation for Clinical Trials

2011 ◽  
Vol 6 (3) ◽  
pp. 229-254 ◽  
Author(s):  
Behnam A. Baghbaderani ◽  
Karim Mukhida ◽  
Murray Hong ◽  
Ivar Mendez ◽  
Leo A. Behie
Keyword(s):  
Clinical Trials ◽  
Cell Expansion ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

Sonic Hedgehog Regulation of the Neural Precursor Cell Fate During Chicken Optic Tectum Development

2017 ◽  
Vol 64 (2) ◽  
pp. 287-299 ◽  
Author(s):  
Ciqing Yang ◽  
Xiaoying Li ◽  
Qiuling Li ◽  
Han Li ◽  
Liang Qiao ◽  
...  
Keyword(s):  
Cell Fate ◽  
Sonic Hedgehog ◽  
Optic Tectum ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

Neural precursor cell influences on blood–brain barrier characteristics in rat brain endothelial cells

2007 ◽  
Vol 1159 ◽  
pp. 67-76 ◽  
Author(s):  
Joseph C. Lim ◽  
Adam J. Wolpaw ◽  
Maeve A. Caldwell ◽  
Stephen B. Hladky ◽  
Margery A. Barrand
Keyword(s):  
Endothelial Cells ◽  
Rat Brain ◽  
Blood Brain Barrier ◽  
Precursor Cell ◽  
Brain Barrier ◽  
Neural Precursor ◽  
Brain Endothelial Cells ◽  
Neural Precursor Cell ◽  
Blood Brain ◽  
Rat Brain Endothelial Cells

Bioengineering Protocols for Neural Precursor Cell Expansion

2009 ◽  
pp. 105-123 ◽  
Author(s):  
Behnam A. Baghbaderani ◽  
Arindom Sen ◽  
Michael S. Kallos ◽  
Leo A. Behie
Keyword(s):  
Cell Expansion ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell
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