Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

2001 ◽  
Vol 64 (2) ◽  
pp. 183-192 ◽  
Author(s):  
Anne Eckert ◽  
Barbara Steiner ◽  
Celio Marques ◽  
Steffen Leutz ◽  
Helmut Romig ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Amyloid Precursor Protein ◽  
Caspase 3 ◽  
Precursor Protein ◽  
Protein Mutation ◽  
Amyloid Precursor Protein Mutation

Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo

2008 ◽  
Vol 86 (11) ◽  
pp. 2476-2487 ◽  
Author(s):  
Kwang-Woo Ahn ◽  
Yuyoung Joo ◽  
Yoori Choi ◽  
Minji Kim ◽  
Sang Hyoung Lee ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Protein Mutation ◽  
Amyloid Precursor Protein Mutation ◽  
Related Proteins

scholarly journals Neurotoxic Mechanisms Caused by the Alzheimer's Disease-linked Swedish Amyloid Precursor Protein Mutation

2003 ◽  
Vol 278 (30) ◽  
pp. 28294-28302 ◽  
Author(s):  
Celio A. Marques ◽  
Uta Keil ◽  
Astrid Bonert ◽  
Barbara Steiner ◽  
Christian Haass ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Protein Mutation ◽  
Amyloid Precursor Protein Mutation

Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family

1994 ◽  
Vol 168 (1-2) ◽  
pp. 254-256 ◽  
Author(s):  
Lars Lannfelt ◽  
Nenad Bogdanovic ◽  
Henrik Appelgren ◽  
Karin Axelman ◽  
Lena Lilius ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Protein Mutation ◽  
Amyloid Precursor Protein Mutation ◽  
Swedish Family

Novel Leu723Pro amyloid precursor protein mutation increases amyloid ?42(43) peptide levels and induces apoptosis

2000 ◽  
Vol 47 (2) ◽  
pp. 249-253 ◽  
Author(s):  
John B. J. Kwok ◽  
Qiao-Xin Li ◽  
Marianne Hallupp ◽  
Scott Whyte ◽  
David Ames ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Protein Mutation ◽  
Amyloid Precursor Protein Mutation

scholarly journals Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer’s Model

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3511
Author(s):  
Wafaa S. Ramadan ◽  
Saleh Alkarim
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Episodic Memory ◽  
Amyloid Precursor Protein ◽  
Entorhinal Cortex ◽  
Ellagic Acid ◽  
Caspase 3 ◽  
Precursor Protein ◽  
Therapeutic Effects

Patients suffering from Alzheimer’s disease (AD) are still increasing worldwide. The development of (AD) is related to oxidative stress and genetic factors. This study investigated the therapeutic effects of ellagic acid (EA) on the entorhinal cortex (ERC), which plays a major role in episodic memory, in the brains of an AD rat model. AD was induced using AlCl3 (50 mg/kg orally for 4 weeks). Rats were divided into four groups: control, AD model, EA (treated with 50 mg/kg EA orally for 4 weeks), and ADEA (AD rats treated with EA after AlCl3 was stopped) groups. All rats were investigated for episodic memory using the novel object recognition test (NORT), antioxidant serum biomarkers, lipid peroxidation, histopathology of the ERC, and quantitative PCR for the superoxide dismutase (SOD) gene. EA therapy in AD rats significantly increased the discrimination index for NORT and the levels of SOD, glutathione, and total antioxidant capacity. Lipid peroxidation products were decreased, and the neurofibrillary tangles and neuritic plaques in the ERC sections were reduced after EA administration. The decrease in ERC thickness in the AD group, caused by caspase-3-mediated apoptosis and neurotoxicity due to amyloid precursor protein, was modulated by the increased SOD mRNA expression. Adjustment of the ERC antioxidant environment and decreased oxidative stress under EA administration enhanced SOD expression, resulting in the modulation of amyloid precursor protein toxicity and caspase-3-mediated apoptosis, thereby restoring episodic memory.

Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation

Neurology ◽  
2003 ◽  
Vol 60 (6) ◽  
pp. 1020-1022 ◽  
Author(s):  
S. M. Greenberg ◽  
Y. Shin ◽  
T. J. Grabowski ◽  
G. E. Cooper ◽  
G. W. Rebeck ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Hemorrhagic Stroke ◽  
Precursor Protein ◽  
Protein Mutation ◽  
Amyloid Precursor Protein Mutation
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