Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice

2002 ◽  
Vol 70 (5) ◽  
pp. 645-654 ◽  
Author(s):  
Karen L. Baracskay ◽  
Cynthia S. Duchala ◽  
Robert H. Miller ◽  
Wendy B. Macklin ◽  
Bruce D. Trapp
Keyword(s):  
White Matter ◽  
Jimpy Mice

Abnormal glial maturation in the white matter in Jimpy mice

1972 ◽  
Vol 21 (4) ◽  
pp. 272-281 ◽  
Author(s):  
E. Farkas-Bargeton ◽  
O. Robain ◽  
P. Mandel
Keyword(s):  
White Matter ◽  
Jimpy Mice

scholarly journals Astrocytal Changes in the White Matter of Jimpy Mice

1985 ◽  
Vol 48 (4) ◽  
pp. 411-419 ◽  
Author(s):  
Kikuko IMAMOTO
Keyword(s):  
White Matter ◽  
Jimpy Mice

FT-IR microspectroscopic analysis of diseased white matter brain tissues

1995 ◽  
Vol 53 ◽  
pp. 968-969
Author(s):  
Steven M. Le Vine ◽  
David L. Wetzel
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Twitcher Mouse ◽  
Grid Pattern ◽  
Marked Contrast ◽  
Spatially Resolved ◽  
Ft Ir ◽  
Ir Microspectroscopy ◽  
Chemical Evidence

In situ FT-IR microspectroscopy has allowed spatially resolved interrogation of different parts of brain tissue. In previous work the spectrrscopic features of normal barin tissue were characterized. The white matter, gray matter and basal ganglia were mapped from appropriate peak area measurements from spectra obtained in a grid pattern. Bands prevalent in white matter were mostly associated with the lipid. These included 2927 and 1469 cm-1 due to CH2 as well as carbonyl at 1740 cm-1. Also 1235 and 1085 cm-1 due to phospholipid and galactocerebroside, respectively (Figs 1and2). Localized chemical changes in the white matter as a result of white matter diseases have been studied. This involved the documentation of localized chemical evidence of demyelination in shiverer mice in which the spectra of white matter lacked the marked contrast between it and gray matter exhibited in the white matter of normal mice (Fig. 3).The twitcher mouse, a model of Krabbe’s desease, was also studied. The purpose in this case was to look for a localized build-up of psychosine in the white matter caused by deficiencies in the enzyme responsible for its breakdown under normal conditions.

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