scholarly journals Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies

2002 ◽  
Vol 69 (5) ◽  
pp. 567-577 ◽  
Author(s):  
Marina D. Kirkitadze ◽  
Gal Bitan ◽  
David B. Teplow
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders ◽  
Paradigm Shifts

scholarly journals The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders

2019 ◽  
Vol 56 (8) ◽  
pp. 5436-5455 ◽  
Author(s):  
Kinga Czubowicz ◽  
Henryk Jęśko ◽  
Przemysław Wencel ◽  
Walter J. Lukiw ◽  
Robert P. Strosznajder
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders ◽  
Sphingosine 1 Phosphate

scholarly journals The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders

2018 ◽  
Vol 17 (8) ◽  
pp. 721-730 ◽  
Author(s):  
Susana Carmona ◽  
Kathleen Zahs ◽  
Elizabeth Wu ◽  
Kelly Dakin ◽  
Jose Bras ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders

Current Pathogenesis of Alzheimer’s Disease and Plants Derived Neuroprotective Phytoconstituents: A Comprehensive Review

2021 ◽  
Vol 10 ◽  
Author(s):  
Anil Kumar Pradhan ◽  
Bimala Tripathy ◽  
Bimalendu Chowdhury ◽  
Sasmita Kumari Acharjya ◽  
Rajaram Das
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Neurodegenerative Disorders ◽  
Neuroprotective Effect ◽  
Vital Role ◽  
Bioactive Constituents ◽  
Different Types

Background: The exact pathogenesis of Alzheimer’s disease is still a matter to debate, currently there is no reliable therapy established for Alzheimer’s disease. However, several pieces of evidence suggest that the use of plant based phytoconstituents mainly delays the onset of Alzheimer. So, in this review, we collect information about the cause of Alzheimer’s disease hypothesis and neuroprotective effect of phytoconstituents. Objective: This review paper aimed to analyze the current pathogenesis of Alzheimer’s disease and the therapeutic effect of plant phytoconstituents that play a vital role in neuroprotective and antistress activities in Alzheimer’s disease and other neurodegenerative disorders. Methods: The source of literature review obtained from Scopus, Science direct, PubMed, web of science database, and journal by using Alzheimer’s pathogenesis, neuroinflammation, oxidative stress, amyloid beta, flavonoids, alkaloids are important part of these review research. Results: The current review explored the different types of pathogenesis involved in Alzheimer’s disease and the role of phytoconstituents in treatment of it. The collected information showed that plant based constituents inhibit the major cause of Alzheimer’s disease related to amyloid beta, tau protein, oxidative stress, neuroinflammation etc. Conclusion: The study provide the clue for the investigation of eminent bioactive constituents may serves as an alternative candidate against Alzheimer’s disease and other neurodegenerative disorders.

scholarly journals Fatty Acid Binding Protein 3 (FABP3) and Apolipoprotein E4 (ApoE4) as Lipid Metabolism-Related Biomarkers of Alzheimer’s Disease

2021 ◽  
Vol 10 (14) ◽  
pp. 3009
Author(s):  
Maciej Dulewicz ◽  
Agnieszka Kulczyńska-Przybik ◽  
Agnieszka Słowik ◽  
Renata Borawska ◽  
Barbara Mroczko
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Neurodegenerative Disorders ◽  
Study Cohort ◽  
Fatty Acid Binding ◽  
Brain Functions

Background: Lipid metabolism-related biomarkers gain increasing researchers interest in the field of neurodegenerative disorders. Mounting evidence have indicated the role of fatty acid-binding proteins and pathology lipid metabolism in Alzheimer’s Disease (AD). The imbalance of fatty acids (FA) and lipids may negatively affect brain functions related to neurodegenerative disorders. The ApoE4 and FABP3 proteins may reflect processes leading to neurodegeneration. This study aimed to evaluate the relationship between the CSF levels of FABP3 and ApoE4 proteins and cognitive decline as well as the diagnostic performance of these candidate biomarkers in AD and mild cognitive impairment (MCI). Methods: A total of 70 subjects, including patients with AD, MCI, and non-demented controls, were enrolled in the study. CSF concentrations of FABP3 and ApoE4 were measured using immunoassay technology. Results: Significantly higher CSF concentrations of FABP3 and ApoE4 were observed in AD patients compared to MCI subjects and individuals without cognitive impairment. Both proteins were inversely associated with Aβ42/40 ratio: ApoE4 (rho = −0.472, p < 0.001), and FABP3 (rho = −0.488, p < 0.001) in the whole study group, respectively. Additionally, FABP3 was negatively correlated with Mini-Mental State Examination score in the whole study cohort (rho = −0.585 p < 0.001). Conclusion: Presented results indicate the pivotal role of FABP3 and ApoE4 in AD pathology as lipid-related biomarkers, but studies on larger cohorts are needed.

scholarly journals d-Amino Acids and pLG72 in Alzheimer’s Disease and Schizophrenia

2021 ◽  
Vol 22 (20) ◽  
pp. 10917
Author(s):  
Yu-Jung Cheng ◽  
Chieh-Hsin Lin ◽  
Hsien-Yuan Lane
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amino Acids ◽  
Neurodegenerative Disorders ◽  
Neurological Disorders ◽  
Gene Polymorphisms ◽  
Diagnostic Value ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

Numerous studies over the last several years have shown that d-amino acids, especially d-serine, have been related to brain and neurological disorders. Acknowledged neurological functions of d-amino acids include neurotransmission and learning and memory functions through modulating N-methyl-d-aspartate type glutamate receptors (NMDARs). Aberrant d-amino acids level and polymorphisms of genes related to d-amino acids metabolism are associated with neurodegenerative brain conditions. This review summarizes the roles of d-amino acids and pLG72, also known as d-amino acid oxidase activator, on two neurodegenerative disorders, schizophrenia and Alzheimer’s disease (AD). The scope includes the changes in d-amino acids levels, gene polymorphisms of G72 genomics, and the role of pLG72 on NMDARs and mitochondria in schizophrenia and AD. The clinical diagnostic value of d-amino acids and pLG72 and the therapeutic importance are also reviewed.

scholarly journals Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase pathways

2020 ◽  
Vol 18 ◽  
Author(s):  
Aisha Siddiqui ◽  
Md Sayeed Akhtar ◽  
Zahoor Shah ◽  
Iekhsan Othman ◽  
Yatinesh Kumari
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders ◽  
Inflammatory Responses ◽  
Biologically Active ◽  
Biochemical Pathways ◽  
Physiological Processes ◽  
The Central Nervous System ◽  
Metabolism Enzyme

: It is a known fact that inflammation affects several physiological processes, including the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways have been associated with a number of neurodegenerative disorders and Alzheimer’s Disease (AD) is one of them. However, much attention has been given to the link between tau and beta-amyloid hypothesis in AD pathogenesis/prognosis. Increasing evidences suggest that biologically active lipid molecules could influence the pathophysiology of AD via different mechanism of inflammation. In this review, we intend to highlight the role of inflammatory responses in the context of AD with the emphasis on biochemical pathways of lipid metabolism enzyme, 5-lipoxygenase (5-LO).

Multi-target Directed Compounds with Antioxidant and/or Antiinflammatory Properties as Potent Agents for Alzheimer’s Disease

2020 ◽  
Vol 16 ◽  
Author(s):  
Papagiouvannis Georgios ◽  
Theodosis-Nobelos Panagiotis ◽  
Kourounakis N. Panos ◽  
Rekka A. Eleni
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders ◽  
Acetylcholinesterase Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Nootropic Agents ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation

Background: Alzheimer’s Disease (AD) is one of the most common neurodegenerative disorders, characterized by memory deficits and cognitive impairment. Acetylcholinesterase inhibitors, NMDA receptor antagonists and nootropic agents are used clinically, but they have only symptomatic efficacy, attributed to the multifactorial character of AD. The multi-target directed compound approach is gaining attention and has been under investigation lately. Objective: This review selects several research articles, which describe the design, synthesis and biological evaluation of multi-targeting molecules combining antioxidant or/and anti-inflammatory properties. Compounds with these properties are expected to be beneficial in the treatment of AD. Methods: This review summarizes the pathobiochemistry of AD, as well as the role of oxidative stress and inflammation in the progression of neurodegeneration. It presents novel compounds with antioxidant or/and anti-inflammatory activity, that have been tested for their efficacy in neurodegenerative disorders. Results: Various researchers have taken advantage of the multi-targeting drug approach, in order to design molecules which may be developed to useful agents for the treatment of neurodegeneration.

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