Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain

2002 ◽  
Vol 68 (6) ◽  
pp. 761-775 ◽  
Author(s):  
Asha Jyothi M. Siddappa ◽  
Raghavendra B. Rao ◽  
Jane D. Wobken ◽  
Elizabeth A. Leibold ◽  
James R. Connor ◽  
...  
Keyword(s):  
Rat Brain ◽  
Iron Transport ◽  
Transport Proteins ◽  
Regulatory Proteins ◽  
Developmental Changes ◽  
Iron Regulatory Proteins ◽  
Iron Transport Proteins

Transient Expression of Iron Transport Proteins in the Capillary of the Developing Rat Brain

2010 ◽  
Vol 31 (1) ◽  
pp. 93-99 ◽  
Author(s):  
W. M. Yang ◽  
K. J. Jung ◽  
M. O. Lee ◽  
Y. S. Lee ◽  
Y. H. Lee ◽  
...  
Keyword(s):  
Rat Brain ◽  
Transient Expression ◽  
Iron Transport ◽  
Transport Proteins ◽  
Developing Rat ◽  
Iron Transport Proteins

Computational approaches for deciphering the equilibrium and kinetic properties of iron transport proteins

Metallomics ◽  
2017 ◽  
Vol 9 (11) ◽  
pp. 1513-1533 ◽  
Author(s):  
H. Abdizadeh ◽  
A. R. Atilgan ◽  
C. Atilgan ◽  
B. Dedeoglu
Keyword(s):  
Conformational Changes ◽  
Iron Transport ◽  
Molecular Simulations ◽  
Transport Proteins ◽  
Kinetic Properties ◽  
Computational Approaches ◽  
Iron Transport Proteins

Conformational changes in transferrin proteins predicted by molecular simulations.

Iron homeostasis: new tales from the crypt

Blood ◽  
2000 ◽  
Vol 96 (13) ◽  
pp. 4020-4027 ◽  
Author(s):  
Cindy N. Roy ◽  
Caroline A. Enns
Keyword(s):  
Iron Uptake ◽  
Iron Transport ◽  
Iron Homeostasis ◽  
Molecular Mechanisms ◽  
Hereditary Hemochromatosis ◽  
The Body ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Duodenal Epithelium ◽  
Related Proteins

Abstract The enterocyte is a highly specialized cell of the duodenal epithelium that coordinates iron uptake and transport into the body. Until recently, the molecular mechanisms underlying iron absorption and iron homeostasis have remained a mystery. This review focuses on the proteins and regulatory mechanisms known to be present in the enterocyte precursor cell and in the mature enterocyte. The recent cloning of a basolateral iron transporter and investigations into its regulation provide new insights into possible mechanisms for iron transport and homeostasis. The roles of proteins such as iron regulatory proteins, the hereditary hemochromatosis protein (HFE)–transferrin receptor complex, and hephaestin in regulating this transporter and in regulating iron transport across the intestinal epithelium are discussed. A speculative, but testable, model for the maintenance of iron homeostasis, which incorporates the changes in the iron-related proteins associated with the life cycle of the enterocyte as it journeys from the crypt to the tip of the villous is proposed.

Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats

2014 ◽  
Vol 52 (1) ◽  
pp. 101-114 ◽  
Author(s):  
Fang Du ◽  
Zhong-Ming Qian ◽  
Qianqian Luo ◽  
Wing-Ho Yung ◽  
Ya Ke
Keyword(s):  
Iron Transport ◽  
Transport Proteins ◽  
Iron Accumulation ◽  
Brain Iron ◽  
Iron Transport Proteins

scholarly journals Presence of Two Iron-Transport Proteins in Serum

Nature ◽  
1961 ◽  
Vol 192 (4798) ◽  
pp. 181-181 ◽  
Author(s):  
M. FABER ◽  
R. JORDAL
Keyword(s):  
Iron Transport ◽  
Transport Proteins ◽  
Iron Transport Proteins

Iron homeostasis: new tales from the crypt

Blood ◽  
2000 ◽  
Vol 96 (13) ◽  
pp. 4020-4027 ◽  
Author(s):  
Cindy N. Roy ◽  
Caroline A. Enns
Keyword(s):  
Iron Uptake ◽  
Iron Transport ◽  
Iron Homeostasis ◽  
Molecular Mechanisms ◽  
Hereditary Hemochromatosis ◽  
The Body ◽  
Regulatory Proteins ◽  
Iron Regulatory Proteins ◽  
Duodenal Epithelium ◽  
Related Proteins

The enterocyte is a highly specialized cell of the duodenal epithelium that coordinates iron uptake and transport into the body. Until recently, the molecular mechanisms underlying iron absorption and iron homeostasis have remained a mystery. This review focuses on the proteins and regulatory mechanisms known to be present in the enterocyte precursor cell and in the mature enterocyte. The recent cloning of a basolateral iron transporter and investigations into its regulation provide new insights into possible mechanisms for iron transport and homeostasis. The roles of proteins such as iron regulatory proteins, the hereditary hemochromatosis protein (HFE)–transferrin receptor complex, and hephaestin in regulating this transporter and in regulating iron transport across the intestinal epithelium are discussed. A speculative, but testable, model for the maintenance of iron homeostasis, which incorporates the changes in the iron-related proteins associated with the life cycle of the enterocyte as it journeys from the crypt to the tip of the villous is proposed.

scholarly journals Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro

2001 ◽  
Vol 356 (3) ◽  
pp. 883 ◽  
Author(s):  
Lorraine GAMBLING ◽  
Ruth DANZEISEN ◽  
Susan GAIR ◽  
Richard G. LEA ◽  
Zehane CHARANIA ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Transport ◽  
Placental Transfer ◽  
Transport Proteins ◽  
Iron Transport Proteins
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