The emerging roles of the CDK/cyclin complexes in antiviral innate immunity

2021 ◽  
Author(s):  
Chunfu Zheng ◽  
Yan‐dong Tang
Keyword(s):  
Innate Immunity ◽  
Antiviral Innate Immunity

scholarly journals β-Catenin Is Required for the cGAS/STING Signaling Pathway but Antagonized by the Herpes Simplex Virus 1 US3 Protein

2019 ◽  
Vol 94 (5) ◽  
Author(s):  
Hongjuan You ◽  
Yingying Lin ◽  
Feng Lin ◽  
Mingyue Yang ◽  
Jiahui Li ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Herpes Simplex ◽  
Immune Responses ◽  
Signaling Pathway ◽  
Kinase Activity ◽  
Dna Virus ◽  
Host Immune Responses ◽  
Simplex Virus ◽  
Antiviral Innate Immunity ◽  
Hsv 1

ABSTRACT The cGAS/STING-mediated DNA-sensing signaling pathway is crucial for interferon (IFN) production and host antiviral responses. Herpes simplex virus I (HSV-1) is a DNA virus that has evolved multiple strategies to evade host immune responses. Here, we demonstrate that the highly conserved β-catenin protein in the Wnt signaling pathway is an important factor to enhance the transcription of type I interferon (IFN-I) in the cGAS/STING signaling pathway, and the production of IFN-I mediated by β-catenin was antagonized by HSV-1 US3 protein via its kinase activity. Infection by US3-deficienct HSV-1 and its kinase-dead variants failed to downregulate IFN-I and IFN-stimulated gene (ISG) production induced by β-catenin. Consistent with this, absence of β-catenin enhanced the replication of US3-deficienct HSV-1, but not wild-type HSV-1. The underlying mechanism was the interaction of US3 with β-catenin and its hyperphosphorylation of β-catenin at Thr556 to block its nuclear translocation. For the first time, HSV-1 US3 has been shown to inhibit IFN-I production through hyperphosphorylation of β-catenin and to subvert host antiviral innate immunity. IMPORTANCE Although increasing evidence has demonstrated that HSV-1 subverts host immune responses and establishes lifelong latent infection, the molecular mechanisms by which HSV-1 interrupts antiviral innate immunity, especially the cGAS/STING-mediated cellular DNA-sensing signaling pathway, have not been fully explored. Here, we show that β-catenin promotes cGAS/STING-mediated activation of the IFN pathway, which is important for cellular innate immune responses and intrinsic resistance to DNA virus infection. The protein kinase US3 antagonizes the production of IFN by targeting β-catenin via its kinase activity. The findings in this study reveal a novel mechanism for HSV-1 to evade host antiviral immunity and add new knowledge to help in understanding the interaction between the host and HSV-1 infection.

scholarly journals Erratum: Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity.

2016 ◽  
Vol 17 (8) ◽  
pp. 1005-1005 ◽  
Author(s):  
Xia Li ◽  
Qian Zhang ◽  
Yuanyuan Ding ◽  
Yiqi Liu ◽  
Dezhi Zhao ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Antiviral Innate Immunity

scholarly journals Development of Antiviral Innate Immunity During In Vitro Differentiation of Mouse Embryonic Stem Cells

2016 ◽  
Vol 25 (8) ◽  
pp. 648-659 ◽  
Author(s):  
William D'Angelo ◽  
Dhiraj Acharya ◽  
Ruoxing Wang ◽  
Jundi Wang ◽  
Chandan Gurung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Innate Immunity ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
In Vitro Differentiation ◽  
Antiviral Innate Immunity

scholarly journals Structural Basis for the Prion-Like Mavs Filaments in Antiviral Innate Immunity

2014 ◽  
Vol 106 (2) ◽  
pp. 684a ◽  
Author(s):  
Hui Xu ◽  
Xiaojing He ◽  
Hui Zheng ◽  
Lily Huang ◽  
Fajian Hou ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Structural Basis ◽  
Antiviral Innate Immunity

A new crustin homologue (SpCrus6) involved in the antimicrobial and antiviral innate immunity in mud crab, Scylla paramamosain

2019 ◽  
Vol 84 ◽  
pp. 733-743 ◽  
Author(s):  
Zhi-qiang Du ◽  
Yue Wang ◽  
Hong-yu Ma ◽  
Xiu-li Shen ◽  
Kai Wang ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Scylla Paramamosain ◽  
Mud Crab ◽  
Antiviral Innate Immunity

scholarly journals Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Yuheng Shi ◽  
Bofeng Yuan ◽  
Wenting Zhu ◽  
Rui Zhang ◽  
Lin Li ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Antiviral Innate Immunity
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