scholarly journals Repurposing of Mycobacterium indicus pranii for the severe form of COVID ‐19 patients in India: A cohort study

2021 ◽  
Author(s):  
Naveed Nazir Shah ◽  
Khurshid Ahmad Dar ◽  
Syed Quibtiya ◽  
Aaliya Mohi Ud Din Azad ◽  
Mehvish Mushtaq ◽  
...  
Keyword(s):  
Cohort Study ◽  
Severe Form ◽  
Mycobacterium Indicus Pranii

scholarly journals Safety and immunogenicity of the BBIBP-CorV vaccine in adolescents aged 12-17 years in Thai population, prospective cohort study.

2022 ◽  
Author(s):  
Kriangkrai Tawinprai ◽  
Taweegrit Siripongboonsitti ◽  
Thachanun Porntharukchareon ◽  
Preeda Vanichsetakul ◽  
Saraiorn Thonginnetra ◽  
...  
Keyword(s):  
Cohort Study ◽  
Adverse Events ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Severe Form ◽  
Antibody Concentration ◽  
P Value ◽  
Serious Adverse Events ◽  
Thai Population ◽  
Thai Adolescents

Introduction: COVID-19 pandemic affects all populations worldwide, including adolescents. Adolescents can develop a severe form of COVID-19, especially with comorbidity underlying. The prior studies of the mRNA COVID-19 vaccine showed excellent effectiveness in adolescents. Therefore, this study aimed to evaluate the safety and effectiveness of the BBIBP-CorV vaccine with the immunobridging approach in Thai adolescents. Methods: This single-center, prospective cohort study compared the immunogenicity after 2 doses of the BBIBO-CorV vaccine with 21 days interval of participants aged 12-17 years with 18-30 years at Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand. The key eligible criteria were healthy or had stable pre-existing comorbidity participants, aged 12-17 years. The primary endpoint was the anti-receptor binding domain antibody concentration at 4 weeks after dose 2 of the vaccine. In addition, safety profiles were solicited adverse events within 7 days after each dose of vaccine and any adverse events through 1 month after dose 2 of the vaccine. Results: Four weeks after the second vaccination, the GMC of anti-RBD antibody in the adolescent cohort was 102.9 BAU/mL (95%CI; 91.0-116.4) and 36.9 BAU/mL (95%CI; 30.9-44.0) in the adult cohort. The GMR of the adolescent cohort was 2.79 (95%CI; 2.25-3.46, p-value; <0.0001) compared with the adult cohort which met non-inferiority criteria. The reactogenicity was slightly less reported in the adolescent cohort compared with the adult cohort. No serious adverse events were reported in both cohorts. Conclusion: Vaccination with the BBIBP-CorV vaccine in the adolescent participants was safe and effective.

scholarly journals Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever

2018 ◽  
Vol 62 (11) ◽  
Author(s):  
Elena Espejo ◽  
Marta Andrés ◽  
Maria-Consol Garcia ◽  
Anna Fajardo ◽  
Josefa Pérez ◽  
...  
Keyword(s):  
Cohort Study ◽  
Adverse Effects ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Adverse Reactions ◽  
Spotted Fever ◽  
Severe Form ◽  
Time Interval ◽  
Mediterranean Spotted Fever ◽  
Oral Doses

ABSTRACTThe objective of this study is to evaluate the results of single-day doxycycline therapy for Mediterranean spotted fever (MSF). This is a prospective cohort study of cases with confirmed MSF treated with the single-day doxycycline regimen in a teaching hospital from 1990 to 2015. Patients received two oral doses of 200 mg of doxycycline for 1 day. The outcomes evaluated were the time interval between the start of treatment and apyrexia, the time interval between the start of treatment and disappearance of other symptoms, and the adverse reactions to treatment and death. The study included 158 subjects, 18 of whom (11.4%) had a severe form of MSF and 31 (19.6%) were >65 years. The interval between onset of symptoms and start of treatment was 4.31 ± 1.54 days. All patients recovered uneventfully. Fever disappeared 2.55 ± 1.14 days after the start of treatment. The remaining symptoms (headache, arthromyalgia) disappeared 3.63 ± 1.35 days after the start of treatment. Only one patient had a delay in reaching apyrexia (8 days). The fever disappeared somewhat later in severe cases (median, 3 days; interquartile range [IQR], 2 to 4 days) than in nonsevere cases (median, 2 days; IQR, 2 to 3 days). Likewise, the remaining symptoms disappeared later in severe cases (median, 5 days; IQR, 4 to 6 days) than in nonsevere cases (median, 3 days; IQR, 3 to 4 days). The outcome was similar in both elderly and nonelderly patients. Eight patients had mild adverse effects possibly related to treatment. The results of the study confirm that single-day doxycycline therapy is an effective and well-tolerated treatment for MSF, including elderly patients and severe cases.

Natural history of helicobacter pylori infection from infancy to adulthood: A 21-year follow-up cohort study

2001 ◽  
Vol 120 (5) ◽  
pp. A128-A128 ◽  
Author(s):  
H MALATY ◽  
D GRAHAM ◽  
A ELKASABANY ◽  
S REDDY ◽  
S SRINIVASAN ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Cohort Study ◽  
Natural History ◽  
Helicobacter Pylori Infection ◽  
History Of

Tu1788 CLINICAL CHARACTERISTICS AND TREATMENT DIFFERENCES BETWEEN YOUNGER AND OLDER ONSET MICROSCOPIC COLITIS: A MULTICENTER RETROSPECTIVE COHORT STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-1161
Author(s):  
Amrit K. Kamboj ◽  
Amandeep Gujral ◽  
Elida Voth ◽  
Daniel Penrice ◽  
Jessica McGoldrick ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Clinical Characteristics ◽  
Microscopic Colitis

Organizational Justice and Health of Employees: Prospective Cohort Study.

2013 ◽  
Author(s):  
Mika Kivimaki ◽  
Marko Elovainio ◽  
Jussi Vahtera ◽  
Marianna Virtanen ◽  
Jane E. Ferrie
Keyword(s):  
Cohort Study ◽  
Organizational Justice ◽  
Prospective Cohort Study ◽  
Prospective Cohort

The Maastricht Cohort Study on Fatigue and Psychological Distress at Work: Pilot Studies of the Questionnaire

1999 ◽  
Author(s):  
Ute Bultmann ◽  
Anna J. H. M. Beurskens ◽  
IJmert Kant ◽  
Gerard M. H. Swaen
Keyword(s):  
Cohort Study ◽  
Psychological Distress ◽  
Pilot Studies

The Maastricht Cohort Study on Fatigue and Psychological Distress at Work: Design and First Results

1999 ◽  
Author(s):  
IJmert Kant ◽  
Helga J. van den Elzen ◽  
Anna J. H. M. Beurskens ◽  
Ute Bultmann ◽  
Gerard M. H. Swaen
Keyword(s):  
Cohort Study ◽  
Psychological Distress ◽  
Work Design ◽  
First Results
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