scholarly journals Evaluation of rapid antigen detection test for individuals at risk of SARS‐CoV‐2 under quarantine

2021 ◽  
Author(s):  
Gannon C. K. Mak ◽  
Shermen S. M. Au ◽  
Mick C. W. Yeung ◽  
Dominic M. W. Lau ◽  
Kinson K. S. Lau ◽  
...  
Keyword(s):  
At Risk ◽  
Antigen Detection ◽  
Rapid Antigen Detection Test

scholarly journals 2620. Respiratory Syncytial Virus Rapid Antigen Detection Test, Can It Be Trusted?

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S912-S912
Author(s):  
Nicole Titze ◽  
Jasjit Singh ◽  
Wendi Gornick
Keyword(s):  
Respiratory Syncytial Virus ◽  
Clinical Decision Making ◽  
Fluorescent Antibody ◽  
Antigen Detection ◽  
Urgent Care ◽  
Viral Fusion ◽  
Rapid Antigen Detection Test ◽  
Viral Fusion Protein ◽  
Test Kit ◽  
Syncytial Virus

Abstract Background Many emergency departments and urgent care settings use the commonly available Respiratory Syncytial Virus Rapid Antigen Detection Test (RSV RADT) to diagnose children with RSV. We noted discordant results between RADT and definitive testing. Our study looked at the positive predictive value (PPV) and the false discovery rate (FDR) of the RSV RADT at our facility. Methods We pro- and retrospectively reviewed all patients with positive RSV RAPD tests from July 1, 2017 through March 31, 2019. The test utilized was the QuickVue® RSV Test Kit (QUIDEL Corp, CA, USA), which detects the viral fusion protein present in RSV. Of the tests performed, we chose patients who had definitive testing with either a direct fluorescent antibody (DFA) or a polymerase chain reaction (PCR). We then calculated the PPV as well as the FDR of the RSV RADT during the total interval period, as well as off-season periods (April 1 through October 31) and in-season periods (November 1 through March 31). Results During the study period there were 1128 RSV RADT tests performed, of which 232 had definitive testing with either DFA or PCR (Figures 1 and 2). We found the overall PPV during the study period was 63.3%. During the off-season 30 positive RSV RADT received definitive testing, of which 6 were positive, which yields a PPV of only 20%. In season, 202 RSV RADT received additional testing with 141 positive for RSV. The PPV was 69.8%. The FDR correlated with 36.7% throughout the entire studied period, 80% during the off-season and 30.2% during in-season. As expected, the PPV was higher during times of higher prevalence (Figure 3). Conclusion Based on our results, utilization of the RSV RADT during time of low prevalence yields a high false detection rate and should therefore be discouraged. The use during times of high prevalence yields only modest results and is unlikely to aid in clinical decision-making. Our results differ from those published by the manufacturer (PPV 84%), and may reflect differences in sample collection in the acute care setting. Disclosures All authors: No reported disclosures.

scholarly journals Spectrum and Inoculum Size Effect of a Rapid Antigen Detection Test for Group A Streptococcus in Children with Pharyngitis

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39085 ◽  
Author(s):  
Jérémie F. Cohen ◽  
Martin Chalumeau ◽  
Corinne Levy ◽  
Philippe Bidet ◽  
Franck Thollot ◽  
...  
Keyword(s):  
Size Effect ◽  
Group A Streptococcus ◽  
Inoculum Size ◽  
Antigen Detection ◽  
Rapid Antigen Detection Test ◽  
Group A

scholarly journals Evaluation of a rapid antigen detection test in the diagnosis of streptococcal pharyngitis in children and its impact on antibiotic prescription

2008 ◽  
Vol 62 (6) ◽  
pp. 1407-1412 ◽  
Author(s):  
Helen C. Maltezou ◽  
Vasilios Tsagris ◽  
Anastasia Antoniadou ◽  
Labrini Galani ◽  
Constantinos Douros ◽  
...  
Keyword(s):  
Antibiotic Prescription ◽  
Streptococcal Pharyngitis ◽  
Antigen Detection ◽  
Rapid Antigen Detection Test

scholarly journals UTILITY OF RAPID ANTIGEN DETECTION TEST FOR DIAGNOSIS OF STREPTOCOCCAL A INFECTION DIRECTLY FROM THE THROAT SWAB OF SUSPECTED PATIENTS OF PHARYNGITIS

2018 ◽  
Vol 7 (13) ◽  
pp. 1616-1619
Author(s):  
Shubham Gupta ◽  
Kaore Navinchandra M ◽  
Sadat Qureshi ◽  
Avinash Laghawe ◽  
Arti Jain ◽  
...  
Keyword(s):  
Throat Swab ◽  
Antigen Detection ◽  
Rapid Antigen Detection Test

scholarly journals Evaluation of Large-Scale Rapid Antigen Testing of Incoming Passengers at a Dynamic Point of Care Setting Carried Out by Dental Students for Covid-19 Screening – A Field Report

2021 ◽  
Vol 10 (33) ◽  
pp. 2734-2739
Author(s):  
Akshay K. Langalia ◽  
Dolly P. Patel ◽  
Aravind D. Kumbhar ◽  
Hetal J. Maheshwari ◽  
Shubhangi K. Vyas ◽  
...  
Keyword(s):  
Large Scale ◽  
Point Of Care ◽  
Dental Students ◽  
Antigen Detection ◽  
Rapid Antigen Detection Test ◽  
Molecular Tests ◽  
Testing Facility ◽  
Field Report ◽  
Antigen Testing ◽  
Central Station

BACKGROUND Assessment of the results of large-scale rapid antigen diagnostic (RAD) testing for detection of SARS-CoV-2 amongst incoming passengers was carried out by Ahmedabad Municipal Corporation (AMC) Dental College Students at the Central Railway Station of Ahmedabad city. We wanted to determine the sensitivity and specificity of RAD testing for detection of Covid-19 amongst passengers disembarking from scheduled trains arriving at the Central Railway Terminus of Ahmedabad city. METHODS Under the campaign “Chase the Virus” launched by Ahmedabad Municipal Corporation (AMC), Interns & Final Year students of AMC Dental College were trained to carry out rapid antigen testing of scheduled trains running on special routes starting from 07 / 09 / 2020 to 05 / 10 / 2020. 14 dental teams were deputed at a temporary testing facility formulated for day-to-day testing at the Central Station using the standalone Standard - Q Covid-19 Ag testing kit (SD Biosensor, South Korea). RESULTS In total, 18901 travellers were tested in a span of 26 days out of which 324 tested positive with an overall percentage positivity of 1.71 %. An average number of 727 (± 182) tests were performed with an overall sensitivity of 66.01 % and specificity of 99.71 %. CONCLUSIONS In response to the growing Covid-19 pandemic and complexity of laboratory-based molecular tests, rapid antigen detection tests have proved to be efficient in the easier and faster diagnosis of the passengers in such point of care settings. KEY WORDS Rapid Antigen Detection Test, Covid-19, SARS-CoV-2

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