scholarly journals Coronavirus genomic nsp14‐ExoN, structure, role, mechanism, and potential application as a drug target

2021 ◽  
Author(s):  
Mohammed Tahir
Keyword(s):  
Potential Application ◽  
Drug Target ◽  
Exon Structure

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

Post-mortem Peyer’s patches: Their potential application in forensic medicine

2009 ◽  
Vol 00 (00) ◽  
pp. 090513010017019-7
Author(s):  
Biagio Solarino ◽  
Giancarlo Di Vella ◽  
Thea Magrone ◽  
Felicita Jirillo ◽  
Angela Tafaro ◽  
...  
Keyword(s):  
Forensic Medicine ◽  
Potential Application ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Post Mortem

Comparison of Caseinolytic and Fibrinolytic Assays for Plasmin (Fibrinolysin) in “Fibrinolytic Agents”

1966 ◽  
Vol 15 (01/02) ◽  
pp. 252-272
Author(s):  
K. M Moser ◽  
Mary Belle Frey
Keyword(s):  
Linear Relationship ◽  
Potential Application ◽  
Fibrinolytic Agents ◽  
Linear Portion

Summary1. Caseinolytic and fibrinolytic systems for assay of plasmin in fibrinolytic agents are described which are based upon the determinations of AE/min during the linear portion of the casein-plasmin and fibrin-plasmin reaction curves respectively. A " caseinolytic-rate " unit and “fibrinolytic-rate " unit of ÄE/min × 103 during the linear portion of the respective curves are proposed.2. Data are presented indicating that a reliably linear relationship exists between plasmin concentration and these caseinolytic - and fibrinolytic-rate units.3. Data comparing results obtained with the proposed assay techniques and previously-used casein and fibrinolytic techniques are presented.4. Formulae by which caseinolytic-rate and fibrinolytic-rate units can be roughly converted into Remmert-Cohen type plasmin units are offered.5. The theoretical and practical problems which have influenced development of assays for fibrinolytic components are discussed.6. The advantages of the plasmin “rate unit” techniques vis a vis existing assays are delineated.7. The potential application of the techniques to measurements other than the plasmin content of fibrinolytic agents is discussed.

CGMP as a New Drug Target in Atrial Fibrillation

2020 ◽  
Author(s):  
N. I. Bork ◽  
N. Grammatika-Pavlidou ◽  
B. Reiter ◽  
E. Girdauskas ◽  
H. Reichenspurner ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Drug Target ◽  
New Drug

Cyclin dependent kinase 4 as promising drug target in adrenocortical carcinoma

2019 ◽  
Author(s):  
Raimunde Liang ◽  
Isabel Weigand ◽  
Silviu Sbiera ◽  
Stefan Kircher ◽  
Juliane Lippert ◽  
...  
Keyword(s):  
Adrenocortical Carcinoma ◽  
Drug Target ◽  
Cyclin Dependent Kinase
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