Effectiveness of retreatment with ombitasvir/paritaprevir/ritonavir, dasabuvir + sofosbuvir + ribavirin in patients with chronic hepatitis C, subtype 1b and cirrhosis, who failed previous with first‐ and second‐generation NS5A inhibitors

2021 ◽  
Author(s):  
Sergii V. Fedorchenko ◽  
Tatiana Martynovych ◽  
Zhanna Klimenko ◽  
Iryna Solianyk
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Second Generation ◽  
First And Second Generation ◽  
Subtype 1B

scholarly journals Distribution of hepatitis C virus genotypes and subtypes in a group of patients with chronic hepatitis C from Canton Sarajevo, 2012-2018

2019 ◽  
Vol 49 ◽  
Author(s):  
Irma Salimović- Bešić ◽  
Adna Kahriman ◽  
Suzana Arapčić ◽  
Amela Dedeić- Ljubović
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hcv Rna ◽  
Genotype 3 ◽  
Hcv Genotype ◽  
Hcv Genotypes ◽  
Number Of Patients ◽  
Subtype 1B

Background: Hepatitis C virus (HCV) genotypes and subtypes exhibit significant geographic variations.Aim: To analyse the distribution of genotypes/subtypes of HCV in a group of patients with chronic hepatitis C from Canton Sarajevo during 2012-2018.Material and methods:The study enrolled 247 human plasma samples of HCV-RNA positive patients with available results of HCV genotyping test.Results: During 2012-2018, the domination of subtypes 1a (34.01%), 1b (28.34%) and genotype 3 (23.89%) was registered. In 2012 and 2013, HCV subtype 1a was the most common (27/63; 42.86% and 17/40; 42.50%, respectively). In 2014, the leading HCV genotype/subtype were 3 and 1b (17/57; 29.82%). In 2015, the dominance of HCV genotype 3 (14/39; 35.90%) continued, while in 2016, the same number of HCV subtypes 1a and 1b (11/30; 36.67%) was recorded. Although in a small number of tested, during 2017, HCV subtype 1b was the most prevalent (7/14; 50.00%), and in 2018, it was replaced by a HCV subtype 1a (3/4; 75.00%). Distribution of HCV genotypes/subtypes by age group of patients varied significantly (p=0.000). The largest number of patients (71/247; 28.74%) belonged to the age category 30-39 years and HCV genotypes/subtypes 1, 3, 4, 1a and 1b were identified. Except in 2017, male gender significantly dominated (p=0.000). In males, HCV subtype 1a (68/170; 40.00%) was the most common, while in women it was HCV subtype 1b (44/77; 57.14%).Conclusion: This six-year retrospective study showed the time variations of the circulating HCV genotypes/subtypes among patients with chronic hepatitis C in Canton Sarajevo. Genotyping of the HCV has an important implications for diagnosis and treatment of the patients.

Development of levovirin as a second generation ribavirin for the treatment of chronic hepatitis C

2001 ◽  
Vol 120 (5) ◽  
pp. A569
Author(s):  
Chin-Chung Lin ◽  
Robert Tam ◽  
Robert Orr ◽  
Zhi Hong ◽  
Johnson Yn Lau
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Second Generation

Serodiagnosis of chronic hepatitis C in Japan by second-generation recombinant immunoblot assay

1993 ◽  
Vol 17 (2) ◽  
pp. 170-174 ◽  
Author(s):  
Nobukazu Yuki ◽  
Norio Hayashi ◽  
Hideki Hagiwara ◽  
Tetsuo Takehara ◽  
Masahide Oshita ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Second Generation ◽  
Immunoblot Assay ◽  
Recombinant Immunoblot Assay

Improved serodiagnosis of chronic hepatitis C in Japan by a second-generation enzyme-linked immunosorbent assay

1992 ◽  
Vol 37 (3) ◽  
pp. 237-240 ◽  
Author(s):  
Nobukazu Yuki ◽  
Norio Hayashi ◽  
Hideki Hagiwara ◽  
Tetsuo Takehara ◽  
Masahide Oshita ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Immunosorbent Assay ◽  
Second Generation ◽  
Enzyme Linked Immunosorbent Assay

scholarly journals The Structure of Hepatitis C Virus Genotypes/Subtypes in Adult Patients with Chronic Hepatitis C in the Moscow Region

2016 ◽  
Vol 15 (2) ◽  
pp. 11-18
Author(s):  
E. N. Kudryavtseva ◽  
I. M. Korabelnikova ◽  
P. O. Bogomolov ◽  
O. S. Kuzmina ◽  
V. M. Matsievich ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Relative Density ◽  
Chronic Hepatitis C ◽  
Adult Patients ◽  
Moscow Region ◽  
Genotype 2 ◽  
Average Proportion ◽  
Virus Genotypes ◽  
Subtype 1B

The structure of HCV genotypes/subtypes and dynamics of its changes in a cohort of adult patients with chronic hepatitis C (n = 17229) was studied during 2008-2015 in the Moscow region. The prevalence of subtypes 1b and 3A HCV, whose relative density have made 47.5% (95%CI 46.8 - 48.3%) and 39.4% (95% CI 38.7 - 40.2 per cent) respectively was revealed. The average proportion of subtype 1A HCV was 5.4% (95%CI of 5.1 - 5.8%) and genotype 2 - 7.2% (95% CI 6,8 - 7,6%). It was established that the dynamics of 1b subtype HCV relative density was characterized by a moderate decline rate of 1.3% per year, while the proportion of subtype 3A HCV increased (+2.9% per year). The differences in the ratio of subtypes 1b and 3A HCV were revealed when dividing the patients by gender. The subtype 1b HCV was more frequently identified in women during the observation period. In the cohort of male patients a shift of the leading HCV subtype was detected - since 2010, the 3A subtype HCV was identified with a higher frequency than subtype 1b HCV. It was shown that in patients under 30 years the proportion of subtype 3A HCV was higher than in the age group older than 30 years, regardless of gender.

Second generation tests in diagnosis of chronic hepatitis C

The Lancet ◽  
1991 ◽  
Vol 337 (8753) ◽  
pp. 1354 ◽  
Author(s):  
Antonio Craxì ◽  
Germana Fiorentino ◽  
VitoDi Marco ◽  
Liliana Marino ◽  
Silvio Magrin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Second Generation
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