scholarly journals Three salvianolic acids inhibit 2019‐nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2

2021 ◽  
Author(s):  
Shiling Hu ◽  
Jue Wang ◽  
Yongjing Zhang ◽  
Haoyun Bai ◽  
Cheng Wang ◽  
...  
Keyword(s):  
Salvianolic Acids

scholarly journals Phytochemical profile and rosmarinic acid purification from two Peruvian Lepechinia Willd. species (Salviinae, Mentheae, Lamiaceae)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Carlos A. Serrano ◽  
Gretty K. Villena ◽  
Eric F. Rodríguez
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Rosmarinic Acid ◽  
High Resolution Mass Spectrometry ◽  
Simple Procedure ◽  
Botanical Species ◽  
Evaporative Crystallization ◽  
Salvianolic Acids ◽  
Phytochemical Profile ◽  
Resolution Mass

AbstractThe phytochemical profile of Lepechinia meyenii (Walp.) Epling and Lepechina floribunda (Benth.) Epling obtained by liquid chromatography associated with high-resolution mass spectrometry is presented. Forty eight compounds were detected exhibiting a variety of salvianolic acids and abietane phenolic diterpenoids. A simple procedure by cold evaporative crystallization to purify rosmarinic acid from these botanical species was also shown.

Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats

2010 ◽  
Vol 242 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Ming-Kuei Tsai ◽  
Yun-Lian Lin ◽  
Yi-Tsau Huang
Keyword(s):  
Oxidative Stress ◽  
Hepatic Fibrosis ◽  
Salvianolic Acids

scholarly journals Distribution Analysis of Salvianolic Acids in Myocardial Ischemic Pig Tissues by Automated Liquid Extraction Surface Analysis Coupled with Tandem Mass Spectrometry

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Qi Qiu ◽  
Jinglin Cao ◽  
Yu Mu ◽  
Yang Lin ◽  
Yunnan Zhang ◽  
...  
Keyword(s):  
Stability Analysis ◽  
Dose Group ◽  
Liquid Extraction ◽  
Tandem Mass ◽  
Distribution Analysis ◽  
Normal Dose ◽  
Liquid Extraction Surface Analysis ◽  
Liver And Kidney ◽  
Salvianolic Acids ◽  
Signal Intensities

The distribution of active compounds of traditional Chinese medicine Salvia miltiorrhiza Bunge (Chinese name: Danshen) in vivo was determined by establishing a liquid extraction surface analysis coupled with the tandem mass spectrometry (LESA-MS/MS) method. Stability analysis and distribution analysis were designed in the present study using normal animals or a myocardial ischemia model. The model assessment was performed four weeks after surgery, and then three groups were created: a normal-dose group, a model-blank group, and a model-dose group. Meanwhile, Danshen decoction administration began in dose groups and lasted for four weeks. In stability analysis, four salvianolic acids—Danshensu (DSS), caffeic acid (CAA), rosmarinic acid (RA), and salvianolic acid A (SAA)—in kidney tissues from the normal-dose group were detected by LESA-MS/MS under four conditions, and then distribution analysis was conducted in different tissues using the same method. Ejection fraction (EF) and fractional shortening (FS) in animals from two model groups decreased significantly four weeks after surgery (P < 0.01) and were improved after four weeks of Danshen decoction administration (P < 0.01). Results of stability analysis demonstrated that this method was basically stable since there were no significant differences in signal intensities of DSS, CAA, and SAA under four conditions (P > 0.05). Distribution analysis showed the signal intensities of DSS in the liver and kidney and SAA in the heart were higher in the model-dose group than in the normal-dose group (P < 0.05 or P < 0.01). Signal intensities of RA in the liver and kidney, and SAA in the liver were lower in the model-dose group compared with the normal-dose group (P < 0.05 or P < 0.01). In conclusion, Danshen decoction has the effect of improving the ischemic condition in a chronic myocardial ischemia model, and the content of two active compounds increased in the targets. These findings contribute to an understanding of the therapeutic role of Danshen in cardiovascular disease.

A quality marker study on salvianolic acids for injection

Phytomedicine ◽  
2018 ◽  
Vol 44 ◽  
pp. 138-147 ◽  
Author(s):  
Wei Li ◽  
Navaneethakrishnan Polachi ◽  
Xiangyang Wang ◽  
Yang Chu ◽  
Yuan Wang ◽  
...  
Keyword(s):  
Quality Marker ◽  
Salvianolic Acids ◽  
Marker Study

scholarly journals The efficacy and safety of salvianolic acids on acute cerebral infarction treatment

Medicine ◽  
2020 ◽  
Vol 99 (23) ◽  
pp. e20059
Author(s):  
Meiying Xin ◽  
Yulei Hao ◽  
Ge Huang ◽  
Xu Wang ◽  
Zhen Liang ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Acute Cerebral Infarction ◽  
Efficacy And Safety ◽  
Salvianolic Acids

scholarly journals Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2990 ◽  
Author(s):  
Ying Li ◽  
Dandan Yang ◽  
Chunyan Zhu
Keyword(s):  
Membrane Permeability ◽  
Cell Monolayer ◽  
Salvianolic Acid B ◽  
Absorption Enhancement ◽  
Enhancement Effect ◽  
Absorption Enhancers ◽  
Salvianolic Acid ◽  
Salvianolic Acids

For drugs with high hydrophilicity and poor membrane permeability, absorption enhancers can promote membrane permeability and improve oral bioavailability. Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC) is a new kind of absorption enhancer that has good safety. To investigate the absorption enhancement effect of SNAC on non-polar charged and polar charged drugs and establish the absorption enhancement mechanism of SNAC, SNAC was synthesized and characterized. Two representative hydrophilic drugs—notoginsenoside R1 (R1) and salvianolic acids (SAs)—were selected as model drugs. In vitro Caco-2 cells transport and in vivo rat pharmacokinetics studies were conducted to examine the permeation effect of SNAC on R1 and SAs. R1, rosmarinic acid (RA), salvianolic acid B (SA-B) and salvianolic acid B (SA-A) were determined to compare the permeation enhancement of different drugs. The MTT assay results showed that SNAC had no toxicity to Caco-2 cells. The transepithelial electrical resistance (TEER) of Caco-2 cell monolayer displayed that SNAC facilitated passive transport of polar charged SAs through the membrane of epithelial enterocytes. The pharmacokinetics results demonstrated that area under the curve (AUC) of RA, SA-B and SA-A with administration of SAs containing SNAC was 35.27, 8.72 and 9.23 times than administration of SAs. Tmax of RA, SA-B and SA-A were also prolonged. The AUC of R1 with administration of R1 containing SNAC was 2.24-times than administration of R1. SNAC is more effective in promoting absorption of SAs than R1. The study demonstrated that SNAC significantly improved bioavailability of R1 and SAs. What’s more, the effect of SNAC on absorption enhancement of charged drugs was larger than that of non-charged drugs. The current findings not only confirm the usefulness of SNAC for the improved delivery of R1 and SAs but also demonstrate the importance of biopharmaceutics characterization in the dosage form development of drugs.

scholarly journals Health-Promoting Effects of Thymus Phenolic-Rich Extracts: Antioxidant, Anti-inflammatory and Antitumoral Properties

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 814
Author(s):  
Andrea F. Afonso ◽  
Olívia R. Pereira ◽  
Susana M. Cardoso
Keyword(s):  
Phenolic Compounds ◽  
Mediterranean Region ◽  
The West ◽  
Numerous Species ◽  
Anti Cancer ◽  
Growing Body ◽  
Potential Applications ◽  
Health Promoting ◽  
Salvianolic Acids ◽  
Anti Inflammatory

Thymus genus comprises numerous species that are particularly abundant in the West Mediterranean region. A growing body of evidence suggests that many of these species are a rich source of bioactive compounds, including phenolic compounds such as rosmarinic acid, salvianolic acids and luteolin glycosides, able to render them potential applications in a range of industrial fields. This review collects the most relevant studies focused on the antioxidant, anti-inflammatory and anti-cancer of phenolic-rich extracts from Thymus plants, highlighting correlations made by the authors with respect to the main phenolic players in such activities.

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