scholarly journals The association between the level of serum 25(OH) vitamin D, obesity, and underlying diseases with the risk of developing COVID‐19 infection: A case–control study of hospitalized patients in Tehran, Iran

2020 ◽  
Author(s):  
Alireza Abdollahi ◽  
Hasti Kamali Sarvestani ◽  
Zahra Rafat ◽  
Sara Ghaderkhani ◽  
Maedeh Mahmoudi‐Aliabadi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Case Control ◽  
Hospitalized Patients ◽  
25 Oh Vitamin D ◽  
Underlying Diseases ◽  
Control Study

Lower Vitamin D Level as a Risk Factor for Late Onset Neonatal Sepsis: An Observational Case–Control Study

2021 ◽  
Author(s):  
Shaimaa Reda Abdelmaksoud ◽  
Mostafa Abdel-Azim Mostafa ◽  
Rana Atef khashaba ◽  
Effat Assar
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Late Onset ◽  
Case Control ◽  
Sepsis Group ◽  
Term Neonates ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
Control Study

Objective The aim of the study is to investigate the relation of neonatal and maternal vitamin D and late-onset sepsis (LOS) Study Design One-hundred twenty term neonates along with their mothers were enrolled in this case–control study. Sixty neonates who were admitted in the neonatal intensive care unit by LOS and had not been previously admitted for last 48 hours and did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the other hand, 60 healthy term neonates were referred as control group. Maternal and neonatal serum 25-OH vitamin D levels were assessed in both the cohorts. Results Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1 ng/mL, respectively) were significantly lower than in controls (22.7 and 21 ng/mL, respectively) p = 0.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated with C-reactive protein and length of hospital stay (r = −0.616 and −0.596, respectively) p <0.001 for both. With a cut-off value of 12.9 ng/mL, the specificity and positive predictive value of neonatal vitamin D were 83.3 and 74.4%, respectively. The odds ratio was 1.088 (95% CI = 1.034–1.144)) for LOS in vitamin D-deficient neonates. Conclusion Neonates with higher vitamin D level are at lower risk of LOS than those with vitamin D deficiency. Maternal vitamin D correlates with neonatal vitamin D. These data suggest that maternal vitamin supplementation during pregnancy may lower the risk of LOS. Key Points

scholarly journals Serum vitamin-mineral profiles – association with breast cancer risk including dietary patterns and supplements use: a case-control study

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Beata Krusinska ◽  
Lidia Wadolowska ◽  
Malgorzata Anna Slowinska ◽  
Maciej Biernacki ◽  
Marek Drozdowski
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Dietary Patterns ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Case Control ◽  
Serum Folate ◽  
Serum Concentrations ◽  
25 Oh Vitamin D ◽  
Control Study

AbstractBreast cancer is the most diagnosed cancer among women worldwide. Studies regarding diet and blood levels of vitamins and minerals in the breast cancer aetiology are limited and the results are inconclusive. We investigated the association between serum vitamin-mineral profiles (V-MPs) and breast cancer (BC) risk with including dietary patterns (DPs) and use of supplements. This case-control study involved 420 women aged 40–79 years from north-eastern Poland, including 190 newly-diagnosed breast cancer cases. The serum concentrations of vitamins (folate, cobalamin, 25(OH) vitamin D) and minerals (iron, calcium, magnesium) were marked in 129 post-menopausal women (82 controls, 47 cases) using an immune-analyser Cobas e411 and a Cobas Integra 400plus auto-analyser (Roche Diagnostics®), respectively. A posteriori V-MPs were derived with a Principal Component Analysis (PCA). Three PCA-driven DPs: ‘Non-Healthy’, ‘Prudent’, and ‘Margarine and Sweetened Dairy’ were described previously. A logistic regression analysis was performed. The odds ratios (ORs) and 95% confidence interval (95% CI) were calculated. Two serum V-MPs were identified. The ‘Folate-Cobalamin-Vitamin D’ profile was loaded heavily by the folate (factor loading 0.82), cobalamin (0.81) and vitamin D (0.49). The ‘Iron-Calcium’ profile was loaded heavily by the iron (0.81) and calcium (0.77). The ‘Magnesium-vitamin D’ profile was loaded heavily by the magnesium (0.92) and vitamin D (0.39). The risk of BC was lower by 88% (OR: 0.12; 95%Cl: 0.02–0.88; p < 0.05) in the upper tertile of the serum ‘Iron-Calcium’ profile compared to the bottom tertile. The risk of BC was lower by 67% (OR: 0.33; 95%Cl: 0.11–0.97; p < 0.05) at the level of serum 25(OH) vitamin D ≥ 24.6 ng/mL and lower by 68% (OR: 0.32; 95%Cl: 0.11–0.91; p < 0.05) at the level of serum calcium ≥ 9.6 mg/dL. There was the inverse association of the serum ‘Magnesium-Vitamin D’ profile with the risk of BC, which disappeared after adjustment for DPs. No significant association between BC risk and the serum ‘Folate-Cobalamin-Vitamin D’ profile and also folate, cobalamin, iron or magnesium considered separately was revealed. These findings highlight that the higher-adequate serum concentrations of both iron and calcium as well as close-to-adequate concentrations of calcium and vitamin D considered separately may protect against breast cancer among postmenopausal women, independently of dietary patterns and use of supplements. Therefore, women should be screened for blood concentrations of multiple vitamins and minerals in the breast cancer prevention.

scholarly journals Serum 25(OH) Vitamin D and Risk of Breast Cancer: A Nested Case-Control Study from the French E3N Cohort

2010 ◽  
Vol 19 (9) ◽  
pp. 2341-2350 ◽  
Author(s):  
Pierre Engel ◽  
Guy Fagherazzi ◽  
Anne Boutten ◽  
Thierry Dupré ◽  
Sylvie Mesrine ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Case Control Study ◽  
Case Control ◽  
25 Oh Vitamin D ◽  
Nested Case Control ◽  
Control Study

scholarly journals Polymorphisms CYP2R1 rs10766197 and CYP27B1 rs10877012 in Multiple Sclerosis: A Case-Control Study

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
A. Martinez-Hernandez ◽  
E. E. Perez-Guerrero ◽  
M. A. Macias-Islas ◽  
C. A. Nava-Valdivia ◽  
A. Villagomez-Vega ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Disease Progression ◽  
Case Control Study ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
Control Study

Background. Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease. Low vitamin D levels have been reported to be a risk factor for MS, and genetic variances could be implicated. The aim of this study was to evaluate the association of MS with rs10766197 polymorphism of CYP2R1 gene and rs10877012 polymorphism of CYP27B1 gene. The second aim was to analyse whether these polymorphisms are associated with the severity of the progression of MS. Material and Methods. In a case-control study, we included 116 MS patients and 226 controls, all of whom were Mexican Mestizo. MS was diagnosed by McDonald criteria (2017). A complete neurological evaluation was performed to evaluate the severity of disease progression. Serum 25-hydroxyvitamin D [25(OH) vitamin D] levels were measured by ELISA. Single nucleotide polymorphisms rs10766197 of CYP2R1 gene and rs10877012 SNP of CYP27B1 gene were genotyped by real-time PCR. Results. Serum 25(OH) vitamin D levels were lower in MS patients than in controls ( p = 0.009 ). No differences were observed between serum 25(OH) vitamin D levels of MS patients with severe progression compared to low progression ( p = 0.88 ). A higher frequency of the A allele of CYP2R1 rs10766197 was observed between MS patients and controls ( p = 0.05 ). No differences were observed in the frequency of T allele of CYP27B1 rs10877012 ( p = 0.65 ). In subanalysis, patients with GA + AA genotypes of CYP2R1 rs10766197 had an increased risk of MS compared to controls ( p = 0.03 ). No increased risk was observed in GT + TT genotypes of CYP27B1 rs10877012 ( p = 0.63 ). No differences were observed in allele frequencies of either polymorphism between patients with severe vs. low disease progression. Conclusion. Lower serum 25(OH) vitamin D levels were observed in MS patients than in controls, although these levels were not associated with disease progression. Carriers of GA + AA genotypes of CYP2R1 rs10766197 had an increased risk of MS. None of these polymorphisms was associated with severe progression of MS.

scholarly journals Vitamin D Deficiency in Children with Acute Bronchiolitis: A Prospective Cross-Sectional Case- Control Study

2021 ◽  
Author(s):  
Inbal Golan-Tripto ◽  
Neta Loewenthal ◽  
Asher Tal ◽  
Yotam Dizitzer ◽  
Yael Baumfeld ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Febrile Illness ◽  
Case Control ◽  
Acute Bronchiolitis ◽  
Infants And Toddlers ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
Control Study

Abstract Objective: To evaluate serum 25(OH) vitamin D levels in infants and toddlers with acute bronchiolitis (AB), compared to subjects with non-respiratory febrile illness.Methods: a prospective cross-sectional case-control study which compared serum 25(OH) vitamin D levels between infants and toddlers diagnosed with Acute Bronchiolitis (AB) to subjects with non-respiratory febrile illness. Results: 127 patients aged <24 months were recruited; 80 diagnosed with AB and 47 patients with non- respiratory febrile illnesses. Both groups had similar demographics aside from age (mean of 7 months vs. 10 months in the AB group compared to control group (p=0.03)) and respiratory symptoms. Serum 25(OH) vitamin D levels were significantly lower in the bronchiolitis group; median [IQR] 28[18-52] vs. 50[25-79] nmol/L, respectively, (p=0.005). Deficient vitamin D levels (<50nmol/L) was found more frequently in AB than controls; 73% vs. 51% (p=0.028). Multivariate logistic regression, adjusted for age, sex, ethnicity and nutrition, showed vitamin D deficiency was more probable in AB patients; OR[95%CI] 3.139[1.369-7.195]. No correlation was found between serum vitamin D levels and bronchiolitis severity, which was assessed via Modified Tal Score and by length of hospital stay. Conclusion: children with acute bronchiolitis displayed significantly lower vitamin D levels than children with non-respiratory acute febrile illnesses.

scholarly journals Comparison Of The 25oh-vitamin D Levels Between Old Patients Hospitalized For Sars-cov-2 Pneumonia And Patients With Other Acute Illnesses: A Retrospective Case-control Study.

2020 ◽  
Author(s):  
Luca Tomisti ◽  
Nicolò Pulizzi ◽  
Pia Clara Pafundi ◽  
Domenico Macaro ◽  
Liliana Villari ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mortality Risk ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Old Patients ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
Control Study ◽  
Group Serum

Abstract PURPOSE. To assess and compare the serum 25OH-vitamin D levels in three cohorts of patients hospitalized due to acute illness, either related or not to a SARS-COV-2 infection. To investigate, in the patients group with SARS-COV-2 pneumonia, the possible relationship between the serum vit- amin D levels and both disease severity and mortality risk.METHODS. This is a retrospective case-control study. Serum 25OH-vitamin D levels were compared between patients with SARS-COV-2 pneumonia (COVID-19 group, 52 patients), and two control groups, including patients with pneumonia not related to SARS-CoV-2 (NO COVID1 group, 52 patients) and patients with a non-respiratory acute disease (NO COVID2 group, 52 pa- tients).RESULTS. No differences were found in the serum 25 OH-Vitamin D levels among the three groups. In the COVID-19 group, serum 25 OH-Vitamin D levels did not show significant associa- tion with mortality risk (p=0.12), Intensive Care Unit admission risk (p=0.36), inpatients duration (p=0.40) and remission time (p=0.33). Similar results were found for parameters estimating the dis- ease severity, such as basal PO2/FiO2 (p=0.77), worse PO2/FiO2 (p=0.41), basal D-dimer (p=0.46) and basal LDH (p=0.52).CONCLUSIONS. Our data do not show lower 25OH-vitamin D levels in the patients with SARS- COV-2 pneumonia compared to patients hospitalized for other acute illnesses. In the COVID-19 group the 25OH-vitamin D levels did not show significant correlation with a worse outcome.

scholarly journals No Association between 25 (OH) Vitamin D Level And Hypothyroidism among Females

2017 ◽  
Vol 5 (2) ◽  
pp. 126-130 ◽  
Author(s):  
Imad R. Musa ◽  
Gasim I. Gasim ◽  
Sajjad Khan ◽  
Ibrahim A. Ibrahim ◽  
Hamdi Abo-alazm ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Serum Vitamin ◽  
Case Control ◽  
Free T4 ◽  
Serum Vitamin D ◽  
Significant Difference ◽  
25 Oh Vitamin D ◽  
Control Study ◽  
Healthy Females

AIM: The aim was to investigate serum vitamin D (25-OH) level among females with hypothyroidism.MATERIALS AND METHODS: A case-control study (58 in each arm) was conducted in Arar Central Hospital, Kingdom Saudi Arabia. The cases were females with hypothyroidism, and healthy females were controls. TSH, thyroid hormones: Free T3 (FT3) and Free T4 (FT4) and haemoglobin levels were measured in all participants. Serum vitamin D (25-OH) level was measured using the spectrophotometry.RESULTS: While there was no significant difference in the age and haemoglobin level, body mass index (BMI) was significantly higher in the cases. Compared with the controls, cases had significantly higher TSH, had significantly lower T4, and there was no significant difference in FT3 and 25 (OH) vitamin D, [16.1 (8.8-26.7) vs. 14.0 (9.5-20.3 ng/ml; P = 0.577]. Linear regression showed no association between, age, BMI, haemoglobin, TSH, FT3, FT4 and the log of 25 (OH) vitamin D levels.CONCLUSION: There was no significant difference in vitamin D level among females with hypothyroidism and healthy controls.

Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

2021 ◽  
pp. 1-26
Author(s):  
Xue-min Huang ◽  
Yan-hua Liu ◽  
Han Zhang ◽  
Yuan Cao ◽  
Wei-feng Dou ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dietary Intake ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Serum Concentrations ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem mass spectrometry. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the ORs of the highest quartile were 0.45 (95%CI: 0.29-0.71, Ptrend = 0.001) for VD dietary intake and 0.26 (95%CI: 0.11-0.60, Ptrend = 0.003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0.02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0.02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.

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