scholarly journals COVID‐19 related immune hemolysis and thrombocytopenia

2020 ◽  
Vol 93 (2) ◽  
pp. 1164-1170
Author(s):  
Kamal Kant Sahu ◽  
Azra Borogovac ◽  
Jan Cerny
Keyword(s):  
Immune Hemolysis

scholarly journals PRODUCTION OF ULTRASTRUCTURAL MEMBRANE LESIONS BY THE FIFTH COMPONENT OF COMPLEMENT

1971 ◽  
Vol 133 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Margaret J. Polley ◽  
Hans J. Müller-Eberhard ◽  
Joseph D. Feldman
Keyword(s):  
Structural Change ◽  
Cell Membrane ◽  
Quantitative Relationship ◽  
Intermediate Complex ◽  
Reaction Sequence ◽  
Immune Hemolysis ◽  
Physical Presence ◽  
Reverse Situation

A direct quantitative relationship has been demonstrated between the number of cell bound C4,2 complexes or C5 molecules and the number of ultrastructural lesions visualized on the cell membrane subsequent to immune hemolysis. When bound C4,2 complexes exceeded bound C5 molecules, the number of ultrastructural lesions seen corresponded to the number of C5 molecules. However, in the reverse situation, with bound C5 molecules in excess of bound C4,2 complexes, the latter determined the number of lesions. During the complement-reaction sequence, the lesions first became visible in the nonlytic intermediate complex EAC1,4,2,3,5 and their number was unaffected when lysis was induced by C6–C9. Since the lesions were also demonstrable on the intermediate complex EC5,6,7, it is concluded that the protein C5 is responsible for their production. Once formed, the physical presence of the C5 molecule is no longer required for the manifestation of the lesions as indicated by persistence of lesions after removal of C5 protein by trypsin. The C5-dependent ultra-structural phenomenon has therefore been interpreted to represent a true structural change of the membrane which, however, is not accompanied by a permeability defect.

Erythropoietin in the treatment of delayed immune hemolysis of a major ABO-incompatible bone marrow transplant

1994 ◽  
Vol 45 (3) ◽  
pp. 237-239 ◽  
Author(s):  
J. López ◽  
J. L. Steegmann ◽  
G. Pérez ◽  
M. J. Otero ◽  
M. Berberana ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Marrow Transplant ◽  
Immune Hemolysis

Piperacillin-induced immune hemolysis: new cases and a concise review of the literature

Transfusion ◽  
2009 ◽  
Vol 50 (5) ◽  
pp. 1135-1138 ◽  
Author(s):  
Beate Mayer ◽  
Salih Yürek ◽  
Abdulgabar Salama
Keyword(s):  
Review Of The Literature ◽  
Concise Review ◽  
Immune Hemolysis

scholarly journals THE EFFECT OF RHEUMATOID FACTORS AND OF ANTIGLOBULINS ON IMMUNE HEMOLYSIS IN VIVO

1963 ◽  
Vol 117 (1) ◽  
pp. 105-125 ◽  
Author(s):  
Manuel E. Kaplan ◽  
James H. Jandl
Keyword(s):  
Protein Content ◽  
Blood Stream ◽  
Body Fluids ◽  
Red Cells ◽  
Rheumatoid Factors ◽  
Low Protein ◽  
Immune Hemolysis

Studies were undertaken in man and in the rat comparing the effects of rheumatoid factors and immune antiglobulins on red cells sensitized with incomplete antibodies. The interaction of immune antiglobulins with sensitized red cells produced (a) agglutination in vitro and (b) an accelerated sequestration of the sensitized cells in vivo. In contrast, rheumatoid macroglobulins, although capable of agglutinating Rh-sensitized red cells in vitro, did not modify their destruction in vivo. The failure of rheumatoid factors to function as antiglobulins in vivo appears to reflect their non-reactivity with sensitized cells in whole serum. It is suggested: (a) that the native (7S) gamma globulins of plasma competitively inhibit rheumatoid factors from reacting with fixed antibody in the blood stream; (b) that if these macroglobulins do indeed have pathogenetic activity, this may be limited to body fluids of low protein content.

scholarly journals Immune Hemolytic Anemia: A Report of Two Cases

2009 ◽  
Vol 1 (01) ◽  
pp. 022-024
Author(s):  
Paramjit Kaur ◽  
Sabita Basu ◽  
Ravneet Kaur ◽  
Gagandeep Kaur
Keyword(s):  
Hemolytic Anemia ◽  
Transfusion Medicine ◽  
Red Cell ◽  
Difficult Situation ◽  
Immune Hemolysis ◽  
Immune Hemolytic Anemia

ABSTRACTThe transfusion-medicine specialists and physicians are often in a difficult situation when the patient has severe worsening anemia and all the blood is mismatched. This situation can arise in patients with red cell autoantibodies or alloantibodies due to previous transfusions. We report two cases of immune hemolysis - one due to warm auto antibodies and the second due to alloimmunization from multiple transfusions.

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