Respiratory syncytial virus in influenza‐like illness cases: Epidemiology and molecular analyses of four consecutive winter seasons (2014‐2015/2017‐2018) in Lombardy (Northern Italy)

2020 ◽  
Vol 92 (12) ◽  
pp. 2999-3006
Author(s):  
Laura Pellegrinelli ◽  
Cristina Galli ◽  
Laura Bubba ◽  
Danilo Cereda ◽  
Giovanni Anselmi ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Northern Italy ◽  
Molecular Analyses ◽  
Influenza Like Illness ◽  
Syncytial Virus

scholarly journals Respiratory syncytial virus (RSV) in pediatric influenza-like illness (ILI) cases in Lombardy, Northern Italy, during seven consecutive winter seasons (from 2014-2015 to 2020-2021)

2021 ◽  
Author(s):  
Laura Pellegrinelli ◽  
Cristina Galli ◽  
Laura Bubba ◽  
Arlinda Seiti ◽  
Giovanni Anselmi ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Influenza Infection ◽  
Northern Italy ◽  
Influenza Viruses ◽  
Influenza Surveillance ◽  
Reference Laboratory ◽  
Risk Of Infection ◽  
Influenza Like Illness ◽  
Rsv Infection ◽  
Syncytial Virus

INTRODUCTION. Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract illness in young children and can also cause influenza-like illness (ILI). Here we investigated the epidemiological features of RSV infection in pediatric ILI cases in Lombardy (a region in Northern Italy accounting nearly 10-million inhabitants) from 2014-2015 to 2020-2021 winter seasons. MATERIAL AND METHODS. Data for this study were retrieved and statistically analyzed from the database of virological influenza surveillance of the regional reference laboratory for Lombardy within the Italian influenza surveillance network (InfluNet). RESULTS. RSV accounting for nearly 19% of pediatric ILI with a risk of infection nearly 2-fold greater than that of individuals ≥15 years. The RSV positivity rate increased to 28% considering 0-5 years old children. Although in children ≤5 years the risk of infection from influenza viruses resulted nearly 2-fold higher than the risk of RSV infection, the age group 4-6 months and 7-12 months showed 5-fold greater risk of infection from RSV than from influenza. Children ≤5 years of age with presence of one or more comorbidities had a nearly 5-fold greater risk of getting RSV infection than otherwise healthy 0-5 years old children. DISCUSSION. The use of the ILI sentinel surveillance allowed us to identify groups at higher risk of RSV and influenza infection and to define the start, duration, timing and intensity of the RSV and influenza community circulation, determining thresholds based on historical data. This surveillance approach can be implemented to assess the nearly real-time RSV circulation and impact.

Clinical characterization of influenza A and human respiratory syncytial virus among patients with influenza like illness

2016 ◽  
Vol 89 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Swati Saxena ◽  
Dharamveer Singh ◽  
Amreen Zia ◽  
Jyoti Umrao ◽  
Naveen Srivastava ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Influenza A ◽  
Human Respiratory Syncytial Virus ◽  
Influenza Like Illness ◽  
Syncytial Virus

scholarly journals Epidemiological parameter review and comparative dynamics of influenza, respiratory syncytial virus, rhinovirus, human coronavirus, and adenovirus

2020 ◽  
Author(s):  
Julie A. Spencer ◽  
Deborah P. Shutt ◽  
Sarah K. Moser ◽  
Hannah Clegg ◽  
Helen J. Wearing ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Literature Review ◽  
Morbidity And Mortality ◽  
Extensive Literature ◽  
Human Coronavirus ◽  
Seir Model ◽  
Influenza Like Illness ◽  
Comparative Dynamics ◽  
Syncytial Virus ◽  
Parameter Values

Influenza-like illness (ILI) accounts for a large burden of annual morbidity and mortality worldwide. A finer-grained knowledge of the parameters and dynamics of the viruses commonly underlying ILI is needed for modeling, diagnostic, and intervention efforts. We conducted an extensive literature review for epidemiological parameter values for influenza, respiratory syncytial virus (RSV), rhinovirus, human coronavirus (HCoV), and adenovirus. We also developed a deterministic SEIR model for ILI, and derived an expression for R0. We here report ranges and means for parameters for these five common viruses.

scholarly journals Clinical characteristics and outcomes of adult patients hospitalized with influenza, respiratory syncytial virus and human metapneumovirus infections: a prospective, cohort study

2020 ◽  
Author(s):  
Liang Chen ◽  
Xiudi Han ◽  
Lu Bai ◽  
Jian Zhang
Keyword(s):  
Influenza Virus ◽  
Respiratory Syncytial Virus ◽  
Disease Severity ◽  
Clinical Features ◽  
Mortality Risk ◽  
Clinical Characteristics ◽  
Viral Infections ◽  
Human Metapneumovirus ◽  
Influenza Like Illness ◽  
Syncytial Virus

Abstract Background Respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and influenza virus infections cause countless adult hospitalizations each year, yet the clinical characteristics and outcomes of RSV and hMPV infections in adults remain poorly understood. This study was thus designed to compare the clinical findings and severity between adult patients hospitalized with RSV/hMPV infections relative to those hospitalized with influenza.Methods This study prospectively enrolled 594 patients that had been hospitalized with influenza-like illness and laboratory confirmed RSV, hMPV, or influenza viral infections over the course of three consecutive influenza seasons at a tertiary hospital in China. In order to identify clinical features associated with these three viral infections and with disease severity, univariate and multivariate logistic regression analyses were conducted. Results Myalgia and lymphocyte counts < 0.8×109/L were positively correlated with the incidence of influenza infection, whereas age ≥ 65 years, nasal congestion, dyspnea, and the presence of solid malignant tumors were positively associated with RSV or hMPV infections. However, none of these variables exhibited good predictive performance as a means of discriminating among patients infected with these three different viruses (AUC < 0.70). After controlling for potential confounding variables, RSV infections in pneumonia patients were associated with a comparable 30-day mortality risk [odds ratio (OR) 1.016, 95% confidence interval (CI) 0.267-3.856, p = 0.982], whereas hMPV infection was associated with a reduced risk of mortality (OR 0.144, 95% CI 0.027-0.780, p = 0.025). In patients without pneumonia, however, 30-day mortality risk in patients infected with influenza virus was comparable to that in patients infected with RSV (OR 1.268, 95% CI 0.172-9.355, p = 0.816) or hMPV (OR 1.128, 95% CI 0.122-10.419, p = 0.916). Conclusions Clinical features of influenza, RSV, and hMPV infections are helpful , but not sufficiently distinct to permit discrimination among these three different infection types, and specific pathogenic testing is thus necessary to understand the etiological basis for disease in patients with influenza-like illness. In addition, disease severity associated with these three types of viral infection was inconsistent when comparing patients with and without pneumonia.

scholarly journals Respiratory Syncytial Virus Infection in Adults Hospitalized With Influenza-Like Illness in France

2016 ◽  
Vol 3 (suppl_1) ◽  
Author(s):  
Paul Loubet ◽  
Nezha Samih-Lenzi ◽  
Martine Valette ◽  
Xavier Duval ◽  
Etienne Canoui ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Influenza Like Illness ◽  
Syncytial Virus
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