Hantavirus infection in Iranian patients suspected to viral hemorrhagic fever

2019 ◽  
Vol 91 (10) ◽  
pp. 1737-1742
Author(s):  
Mostafa Salehi‐Vaziri ◽  
Azadeh Salarian Kaleji ◽  
Mehdi Fazlalipour ◽  
Tahmineh Jalali ◽  
Tahereh Mohammadi ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Hantavirus Infection ◽  
Viral Hemorrhagic Fever ◽  
Iranian Patients

scholarly journals Hemorrhagic fever with renal syndrome (HFRS) in Poland

2019 ◽  
pp. 477-485 ◽  
Author(s):  
Anna Karolina Gut ◽  
Radosław Gut ◽  
Aleksandra Rymarz ◽  
Agnieszka Woźniak-Kosek
Keyword(s):  
Risk Group ◽  
Hemorrhagic Fever ◽  
Hantavirus Infection ◽  
Viral Hemorrhagic Fever ◽  
Professional Literature ◽  
Medical Status ◽  
Hanta Virus

Hemorrhagic fever with renal syndrome (HFRS) is an acute viral zoonosis occurring due to the hantavirus infection. On the territory it constitutes the only case of viral hemorrhagic fever. The infections occurring in Poland are mainly caused by the Puumala and Dobrava serotypes. The pathogenetic influence of other Hanta serotypes such as Boginia, Nova and Seewis on humans is still unknown. The endemic territory of the occurrence of the hantavirus infections in Poland is the Podkarpacie region. The morbidity is not high and ranges between 0.02 and 0.14 in every 100 000 but professional literature suggests that the data concerning the territory of Poland is underestimated. So far hantavirus infections have not been reported in other areas of Poland yet the presence of the virus may be excluded. In view of literature and the significant occurrence of Hanta antibodies in patients included in the risk group, it may be claimed that the diseases caused by Hanta virus constitute a significant factor influencing the medical status of the group in focus all over the country.

MO426HANTA HEMORRHAGIC FEVER WITH RENAL SYNDROME CAUSED BY HANTAAN SEROTIPE IN BALKAN PENINSULA - AN UNESPECTED FINDING

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Gabriela Elena Lupusoru ◽  
Ioana-Georgiana Ailincai ◽  
Andreea Gabriella Andronesi ◽  
Mircea Lupusoru ◽  
Lavinia Maria Bernea ◽  
...  
Keyword(s):  
Kidney Biopsy ◽  
Hemorrhagic Fever ◽  
Balkan Peninsula ◽  
Secondary Hypertension ◽  
Blue Staining ◽  
Hantavirus Infection ◽  
Severe Thrombocytopenia ◽  
Toluidine Blue Staining ◽  
Foot Process ◽  
Hepatic Cytolysis

Abstract Background and Aims Hantavirus infection is a zoonosis rare in the Balkan Peninsula but with increasing frequency and geographic spread, causing two major syndromes, depending on the viral serotype: hemorrhagic fever with renal syndrome (HFRS) and cardiopulmonary syndrome (CPS). Because there is no specific treatment or vaccine for this condition, the key for minimizing the progression to chronic kidney disease, secondary hypertension or death is early diagnosis and prompt therapy. This paper presents a case of HFSR in which needle kidney biopsy played a major role in diagnosis and draws attention on this zoonosis that might be highly underdiagnosed in Balkan Peninsula. Method A 26-year-old female with no medical history was admitted in our department with acute kidney injury (AKI), nephritic syndrome with nephrotic range proteinuria, high blood pressure, hepatic cytolysis, severe thrombocytopenia, anemia and leukocytosis, elevated LDH, normal haptoglobin, positive Coombs test (Table 1). Immunological testing (C3, C4, ANA, ANCA, antiGBM), viral infection markers (hepatitis B/C, HIV, Epstein-Barr, Cytomegalovirus), IgA/M/G were all negative and ADAMTS13 activity was normal. Abdominal sonography showed both kidneys of normal size and shape. A kidney biopsy was performed. The biopsy specimen showed macroscopic features of hemorrhage in the renal medulla. In immunofluorescence the staining was negative for IgA, IgG, IgM, C1q, C3c, k and λ chains, albumin and fibrinogen. Light microscopy (LM) revealed normal glomeruli and arterioles, dilated proximal tubules with resorption droplets at the apical pole and erythrocytes in the lumen, important interstitial hemorrhage in the medulla, with no inflammation or interstitial fibrosis. The electron microscopy (EM) showed segmental foot process effacement, endotheliosis of the peritubular capillaries, rare plasmocytes and macrophages in the interstitium (Figure 1). The aspect of hemorrhagic interstitial nephritis suggested Hantavirus infection. Serological testing revealed both IgM and IgG antibodies for the Hantaan serotype (HTNV). The final diagnosis was HTNV hemorrhagic interstitial nephritis with intrinsic AKI and secondary hypertension. MO426   Figure 1: A, B LM, Toluidine Blue staining. Normal glomerulus. Resorption droplets in the proximal tubular cells. C, D LM, Toluidine Blue staining. Extensive interstitial hemorrhage in medulla, tubulitis. E EM. Interstitial extravasation of erythrocytes. F EM. Endothelial swelling, foot process effacement. Results The patient was treated with oral methylprednisolone 16mg/d for 2 weeks, with progressive tampering of the dose and removal after 2 months. She received antihypertensive and antiproteinuric treatment with ramipril. The evolution was good, with creatinine and liver enzymes returning to normal. Conclusion HFRS belongs to a group of rare zoonoses in Balkan Peninsula, the most involved serotypes being Dobrava and Puumala. This case had positive serology for HTNV usually being found in China and Russia, but our patient didn’t travel abroad before she got ill, so we can’t consider the case as being an imported infection. That highlights a possible underdiagnosis of the disease in this region and also the need to re-evaluate geographic distribution of different strains and changes in ecological aspects given that they may pose a major risk to public health. The disease begins with flu-like symptoms and progresses to AKI with severe thrombocytopenia, anemia and coagulation disorders, being easily mistaken for haemolytic uremic syndrome. In a region with sporadic cases, we face diagnosis difficulties related especially to the absence of initial diagnosis suspicion, so we emphasize the need to include this pathology in the differential diagnosis algorithm of diseases evolving with thrombocytopenia, anemia, hepatic cytolysis and renal injury.

scholarly journals Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus

2004 ◽  
Vol 4 (1) ◽  
Author(s):  
Fatih M Uckun ◽  
Alexander S Petkevich ◽  
Alexei O Vassilev ◽  
Heather E Tibbles ◽  
Leonid Titov
Keyword(s):  
Mouse Model ◽  
Hemorrhagic Fever ◽  
Lassa Virus ◽  
Viral Hemorrhagic Fever ◽  
Experimental Mouse Model ◽  
Experimental Mouse

Dengue Fever: A Viral Hemorrhagic Fever of Global Concern

2020 ◽  
pp. 99-163
Author(s):  
Bennet Angel ◽  
Neelam Yadav ◽  
Jagriti Narang ◽  
Annette Angel ◽  
Vinod Joshi
Keyword(s):  
Dengue Fever ◽  
Hemorrhagic Fever ◽  
Viral Hemorrhagic Fever ◽  
Global Concern

scholarly journals Anterior pituitary lobe atrophy as late complication of hemorrhagic fever with renal syndrome

2009 ◽  
Vol 66 (2) ◽  
pp. 166-168
Author(s):  
Dragan Jovanovic ◽  
Zoran Kovacevic ◽  
Tamara Dragovic ◽  
Marijana Petrovic ◽  
Jelena Tadic
Keyword(s):  
Renal Insufficiency ◽  
Anterior Pituitary ◽  
Late Complication ◽  
Sella Turcica ◽  
Hemorrhagic Fever ◽  
Empty Sella ◽  
Acute Stage ◽  
Hantavirus Infection ◽  
Multisystemic Disease ◽  
Acute Renal Insufficiency

Introduction. Hemorrhagic fever with renal syndrome (HFRS) is acute infective multisystemic disease followed by febrility, hemorrhages and acute renal insufficiency. Bleeding in the anterior pituitary lobe leading to tissue necrosis occurs in acute stage of severe clinical forms of HFRS, while atrophy of the anterior pituitary lobe with diminution of the gland function occurs after recovery stage. Case report. We presented a patient with the development of chronic renal insufficiency and hypopituitarism as complication that had been diagnosed six years after Hantavirus infection. Magnetic resonance of the pituitary gland revealed atrophy and empty sella turcica. Conclusion. Regarding frequency of this viral infection and its endemic character in some parts of our country partial and/or complete loss of pituitary function should be considered during the late stage of HFRS.

“STUDY OF SERUM AMINOTRANSFERASE LEVELS IN DENGUE FEVER”

2021 ◽  
pp. 15-16
Author(s):  
Tabitha R J Chandrika ◽  
Chennakesavulu Dara ◽  
Gandhi Parise ◽  
.Phani Krishna Telluri
Keyword(s):  
Public Health ◽  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
South East Asia ◽  
Adverse Consequence ◽  
Viral Hemorrhagic Fever ◽  
Serum Aminotransferase ◽  
Hepatic Involvement ◽  
Wide Geographical Distribution ◽  
The Right

Dengue infection, an arthropod-borne viral hemorrhagic fever, continues to be a major challenge to public health, especially in South-East Asia. It has a wide geographical distribution and can present with a diverse clinical spectrum. The liver dysfunction could be a direct viral effect or an adverse consequence of dysregulated host immune response against the virus. Hepatic involvement can be characterized by manifestations of acute hepatitis, with pain in the right hypochondrium, hepatomegaly, jaundice, and raised aminotransferase levels. Several outbreaks of dengue infection have been reported from India. However, large clinical studies documenting hepatic involvement in dengue infection, especially in adults, are scarce.

Hemorrhagic fever with renal syndrome with concurrent aortic dissection: a case report

2020 ◽  
Author(s):  
Fengqi Qiu ◽  
Congcong Li ◽  
Jianya Zhou
Keyword(s):  
Acute Kidney Injury ◽  
Aortic Dissection ◽  
Kidney Injury ◽  
Hemorrhagic Fever ◽  
Sudden Onset ◽  
High Fever ◽  
Hantaan Virus ◽  
Hantavirus Infection ◽  
Microvascular Damage ◽  
Stanford B

Abstract Background Hemorrhagic fever with renal syndrome (HFRS) is caused by hantaviruses presenting with high fever, hemorrhage, acute kidney injury. Microvascular injury and hemorrhage in mucus was often observed in patients with hantavirus infection. Infection with bacterial and virus related aortic aneurysm or dissection occurs sporadically. We present a previously unreported case of hemorrhagic fever with concurrent Stanford B aortic dissection. Case presentation: A 56-year-old man complained of high fever, generalized body ache, with decreased platelet counts of 10 × 10^9/L and acute kidney injury. The ELISA test for Hantaan virus of IgM and IgG antibodies were both positive. During the convalescent period, he complained sudden onset acute chest pain radiating to the back and the CTA revealed an aortic dissection of the descending aorta extending to iliac artery. He was diagnosed with Hemorrhagic fever with renal syndrome and Stanford B aortic dissection. The patient recovered completely after surgery with other support treatments. Conclusion We present a case of HFRS complicated with aortic dissection,and no study has reported the association of HFRS with aortic disease. However, we suppose that hantavirus infection not only cause microvascular damage but may be risk factor for acute macrovascular detriment. A causal relationship has yet to be confirmed.

Outbreak investigation and intervention measures following viral hemorrhagic fever in rural Kutch (Gujarat)

2013 ◽  
Vol 2 (3) ◽  
pp. 189 ◽  
Author(s):  
KishorM Dhaduk ◽  
KapiilM Gandha ◽  
NareshR Makwana ◽  
DipeshV Parmar ◽  
SumitV Unadkat ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Outbreak Investigation ◽  
Viral Hemorrhagic Fever ◽  
Intervention Measures

scholarly journals Immune Modulation and Immune-Mediated Pathogenesis of Emerging Tickborne Banyangviruses

Vaccines ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 125 ◽  
Author(s):  
Mendoza ◽  
Ebihara ◽  
Yamaoka
Keyword(s):  
Immune Modulation ◽  
Severe Disease ◽  
Hemorrhagic Fever ◽  
Mortality Rates ◽  
Viral Hemorrhagic Fever ◽  
New Class ◽  
Viral Immune Evasion ◽  
Immune Mediated ◽  
Significant Disease ◽  
Severe Fever

In the last decade, the emergence of several, novel tickborne viruses have caused significant disease in humans. Of interest are the tickborne banyangviruses: Severe fever with thrombocytopenia syndrome virus (SFTSV), Heartland virus (HRTV), and Guertu virus (GTV). SFTSV and HRTV infection in humans cause viral hemorrhagic fever-like disease leading to mortality rates ranging from 6–30% of the cases. The systemic inflammatory response syndrome (SIRS) associated with SFTSV infection is hypothesized to contribute significantly to pathology seen in patients. Despite the severe disease caused by HRTV and SFTSV, there are no approved therapeutics or vaccines. Investigation of the immune response during and following infection is critical to the generation of fully protective vaccines and/or supportive treatments, and overall understanding of viral immune evasion mechanisms may aid in the development of a new class of therapeutics.

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