scholarly journals Impact of genotypic susceptibility score on cART outcomes during primary HIV infection

2019 ◽  
Vol 91 (10) ◽  
pp. 1891-1895
Author(s):  
Andrea Giacomelli ◽  
Massimiliano Fabbiani ◽  
Ilaria Benedetto ◽  
Silvia Nozza ◽  
Emanuele Focà ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Primary Hiv Infection ◽  
Susceptibility Score

Impact of Delaying Antiretroviral Treatment during Primary HIV Infection on Telomere Length

2021 ◽  
Author(s):  
Marieke Raffenberg ◽  
Tanja Engel ◽  
Isabella C Schoepf ◽  
Neeltje A Kootstra ◽  
Peter Reiss ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Telomere Length ◽  
Antiretroviral Treatment ◽  
Mononuclear Cells ◽  
Multivariable Analysis ◽  
Limited Effect ◽  
Peripheral Blood Mononuclear ◽  
Primary Hiv Infection ◽  
Hiv Seroconversion ◽  
Chronic Hiv Infection

Abstract Background Telomere length (TL) shortens during aging, HIV-seroconversion and untreated chronic HIV infection. It is unknown whether early antiretroviral therapy (ART) start is associated with less TL shortening during primary HIV infection (PHI). Methods We measured TL in peripheral blood mononuclear cells by quantitative PCR in participants of the Zurich PHI Study with samples available for >6 years. We obtained uni-/multivariable estimates from mixed-effects models and evaluated the association of delaying ART start or interrupting ART with baseline and longitudinal TL. Results In 105 participants with PHI (median age 36 years, 9% women), median ART delay was 25, 42, and 60 days, respectively, in the 1 st (shortest), 2 nd, and 3 rd (longest) ART delay tertile. First ART delay tertile was associated with longer baseline TL (p for trend=0.034), and longer TL over 6 years, but only with continuous ART (p<0.001), not if ART was interrupted >12 months (p=0.408). In multivariable analysis, participants in the 2 nd and 3 rd ART delay tertile had 17.6% (5.4-29.7%; p=0.004) and 21.5% (9.4-33.5%; p<0.001) shorter TL, after adjustment for age, with limited effect modification by clinical variables. Discussion In PHI, delaying ART start for even a matter of weeks was associated with significant and sustained TL shortening.

scholarly journals Antigen detection in primary HIV infection

BMJ ◽  
1988 ◽  
Vol 296 (6617) ◽  
pp. 238-240 ◽  
Author(s):  
M von Sydow ◽  
H Gaines ◽  
A Sonnerborg ◽  
M Forsgren ◽  
P O Pehrson ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Antigen Detection ◽  
Primary Hiv Infection

Primary HIV infection: from diagnosis to treatment

2004 ◽  
pp. 87-98
Author(s):  
Luc Perrin ◽  
Marie-Charlotte Bernard
Keyword(s):  
Hiv Infection ◽  
Primary Hiv Infection

Symptomatic primary HIV infection or risk experiences? Circumstances surrounding HIV testing and diagnosis among recent seroconverters

2003 ◽  
Vol 14 (9) ◽  
pp. 601-608 ◽  
Author(s):  
Ann N Burchell ◽  
Liviana Calzavara ◽  
Nancy Ramuscak ◽  
Ted Myers ◽  
Carol Major ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Hiv Infection ◽  
Hiv Testing ◽  
Odds Ratio ◽  
Risk Behaviour ◽  
Primary Hiv Infection ◽  
Time Period ◽  
Physician Awareness ◽  
Negative Controls ◽  
Hiv Negative

Our objective was to understand the circumstances surrounding HIV testing among recent HIV seroconverters ( n = 80) compared to HIV-negative controls ( n = 106) in Ontario, Canada using self-reported interview data. Diagnosis of symptomatic primary HIV infection (SPHI) was defined as diagnosis by the participant's physician. Testing in response to symptoms was reported by 42% of seroconverters vs 12% of controls. More controls than seroconverters tested in response to risk behaviour (70% vs 50%) or from a desire to know their status (34% vs 12%). Among seroconverters, 76% reported 'flu-like' illness during the time period of infection, 66% had symptoms consistent with SPHI, and 35% reported a physician's diagnosis of SPHI. Compared to seroconverters with undiagnosed SPHI, more of those diagnosed with SPHI had rash (odds ratio = 4.5). SPHI plays a significant role in HIV testing and subsequent early diagnosis in this population. More seroconversions could be diagnosed with better patient and physician awareness of its symptoms.

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