scholarly journals Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children

2019 ◽  
Vol 91 (7) ◽  
pp. 1250-1262 ◽  
Author(s):  
José Luiz Proenca‐Modena ◽  
Ricardo Souza Cardoso ◽  
Miriã Ferreira Criado ◽  
Guilherme Paier Milanez ◽  
William Marciel Souza ◽  
...  
Keyword(s):  
Human Adenovirus ◽  
Palatine Tonsils ◽  
Adenovirus Replication

scholarly journals The Adenovirus Dodecahedron: Beyond the Platonic Story

Viruses ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 718
Author(s):  
Solène Besson ◽  
Charles Vragniau ◽  
Emilie Vassal-Stermann ◽  
Marie Claire Dagher ◽  
Pascal Fender
Keyword(s):  
Electron Microscopy ◽  
Viral Entry ◽  
Physiological Role ◽  
Human Adenovirus ◽  
Structural Determinants ◽  
Cryo Electron Microscopy ◽  
Therapeutic Development ◽  
Adenovirus Receptor ◽  
Adenovirus Replication ◽  
Potential Use

Many geometric forms are found in nature, some of them adhering to mathematical laws or amazing aesthetic rules. One of the best-known examples in microbiology is the icosahedral shape of certain viruses with 20 triangular facets and 12 edges. What is less known, however, is that a complementary object displaying 12 faces and 20 edges called a ‘dodecahedron’ can be produced in huge amounts during certain adenovirus replication cycles. The decahedron was first described more than 50 years ago in the human adenovirus (HAdV3) viral cycle. Later on, the expression of this recombinant scaffold, combined with improvements in cryo-electron microscopy, made it possible to decipher the structural determinants underlying their architecture. Recently, this particle, which mimics viral entry, was used to fish the long elusive adenovirus receptor, desmoglein-2, which serves as a cellular docking for some adenovirus serotypes. This breakthrough enabled the understanding of the physiological role played by the dodecahedral particles, showing that icosahedral and dodecahedral particles live more than a simple platonic story. All these points are developed in this review, and the potential use of the dodecahedron in therapeutic development is discussed.

Human adenovirus replication in immunocompetent Syrian hamsters can be attenuated with chlorpromazine or cidofovir

2010 ◽  
Vol 12 (5) ◽  
pp. 435-445 ◽  
Author(s):  
Iulia Diaconu ◽  
Vincenzo Cerullo ◽  
Sophie Escutenaire ◽  
Anna Kanerva ◽  
Gerd J. Bauerschmitz ◽  
...  
Keyword(s):  
Human Adenovirus ◽  
Syrian Hamsters ◽  
Adenovirus Replication

scholarly journals Valganciclovir Inhibits Human Adenovirus Replication and Pathology in Permissive Immunosuppressed Female and Male Syrian Hamsters

Viruses ◽  
2015 ◽  
Vol 7 (3) ◽  
pp. 1409-1428 ◽  
Author(s):  
Karoly Toth ◽  
Baoling Ying ◽  
Ann Tollefson ◽  
Jacqueline Spencer ◽  
Lata Balakrishnan ◽  
...  
Keyword(s):  
Human Adenovirus ◽  
Syrian Hamsters ◽  
Adenovirus Replication

scholarly journals The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity

mSphere ◽  
2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Frédéric Dallaire ◽  
Sabrina Schreiner ◽  
G. Eric Blair ◽  
Thomas Dobner ◽  
Philip E. Branton ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
Viral Gene Expression ◽  
Human Adenovirus ◽  
Viral Gene ◽  
Ubiquitin Ligase Complex ◽  
Cellular Dna ◽  
Adenovirus Replication ◽  
Do So

ABSTRACT Following our demonstration that adenovirus E3 ubiquitin ligase formed by the viral E4orf6 and E1B55K proteins is able to mimic the activation of E2F by E1A, we conducted a series of studies to determine if this complex might also promote the ability of E1A to do so. We found that the complex both significantly stabilizes E1A proteins and also enhances their ability to activate E2F. This finding is of significance because it represents an entirely new function for the ligase in regulating adenovirus replication by enhancing the action of E1A products. Human adenovirus (Ad) E1A proteins have long been known as the central regulators of virus infection as well as the major source of adenovirus oncogenic potential. Not only do they activate expression of other early viral genes, they make viral replication possible in terminally differentiated cells, at least in part, by binding to the retinoblastoma (Rb) tumor suppressor family of proteins to activate E2F transcription factors and thus viral and cellular DNA synthesis. We demonstrate in an accompanying article (F. Dallaire et al., mSphere 1:00014-15, 2016) that the human adenovirus E3 ubiquitin ligase complex formed by the E4orf6 and E1B55K proteins is able to mimic E1A activation of E2F transactivation factors. Acting alone in the absence of E1A, the Ad5 E4orf6 protein in complex with E1B55K was shown to bind E2F, disrupt E2F/Rb complexes, and induce hyperphosphorylation of Rb, leading to induction of viral and cellular DNA synthesis, as well as stimulation of early and late viral gene expression and production of viral progeny. While these activities were significantly lower than those exhibited by E1A, we report here that this ligase complex appeared to enhance E1A activity in two ways. First, the E4orf6/E1B55K complex was shown to stabilize E1A proteins, leading to higher levels in infected cells. Second, the complex was demonstrated to enhance the activation of E2F by E1A products. These findings indicated a new role of the E4orf6/E1B55K ligase complex in promoting adenovirus replication. IMPORTANCE Following our demonstration that adenovirus E3 ubiquitin ligase formed by the viral E4orf6 and E1B55K proteins is able to mimic the activation of E2F by E1A, we conducted a series of studies to determine if this complex might also promote the ability of E1A to do so. We found that the complex both significantly stabilizes E1A proteins and also enhances their ability to activate E2F. This finding is of significance because it represents an entirely new function for the ligase in regulating adenovirus replication by enhancing the action of E1A products.

scholarly journals 1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication

Acta Naturae ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 58-64 ◽  
Author(s):  
N. A. Nikitenko ◽  
E. S. Gureeva ◽  
A. A. Ozerov ◽  
A. I. Tukhvatulin ◽  
F. M. Izhaeva ◽  
...  
Keyword(s):  
Human Adenovirus ◽  
Widespread Distribution ◽  
Therapeutic Drugs ◽  
Causal Therapy ◽  
Adenovirus Replication

Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group of diseases, explains the need for new therapeutic drugs. Notably, anti-adenoviral activity of [4-(phenoxy)benzyl]-5-(phenylamino)-6-azauracil, 1-[4-(phenoxy)benzyl]-5-(morpholino) uracil, 1-[4-(4-chlorophenoxy)benzyl]-5-(morpholino) uracil, and 1-[4-(4-fluorophenoxy)-benzyl]-5-(morpholino) uracil was observed.

Restriction of human adenovirus replication in Chinese hamster cell lines and their hybrids with human cells

1987 ◽  
Vol 8 (4) ◽  
pp. 277-299 ◽  
Author(s):  
Rachel L. Radna ◽  
Brigitte Foellmer ◽  
Lawrence A. Feldman ◽  
Uta Francke ◽  
Harvey L. Ozer
Keyword(s):  
Cell Lines ◽  
Chinese Hamster ◽  
Human Adenovirus ◽  
Chinese Hamster Cell ◽  
Human Cells ◽  
Adenovirus Replication

scholarly journals Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections

Viruses ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1322
Author(s):  
Zamaneh Hajikhezri ◽  
Mahmoud Darweesh ◽  
Göran Akusjärvi ◽  
Tanel Punga
Keyword(s):  
Zinc Finger ◽  
Human Adenovirus ◽  
Rna Metabolism ◽  
Zinc Finger Proteins ◽  
Cellular Proteins ◽  
Virus Infections ◽  
Dynamic Changes ◽  
Adenovirus Replication ◽  
Huge Variety

The zinc finger proteins make up a significant part of the proteome and perform a huge variety of functions in the cell. The CCCH-type zinc finger proteins have gained attention due to their unusual ability to interact with RNA and thereby control different steps of RNA metabolism. Since virus infections interfere with RNA metabolism, dynamic changes in the CCCH-type zinc finger proteins and virus replication are expected to happen. In the present review, we will discuss how three CCCH-type zinc finger proteins, ZC3H11A, MKRN1, and U2AF1, interfere with human adenovirus replication. We will summarize the functions of these three cellular proteins and focus on their potential pro- or anti-viral activities during a lytic human adenovirus infection.

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