Frequency and Implications of myeloid-derived suppressor cells and lymphocyte subsets in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma

2019 ◽  
Vol 91 (7) ◽  
pp. 1319-1328 ◽  
Author(s):  
Helal F. Hetta ◽  
Asmaa M. Zahran ◽  
Shima G. Mansor ◽  
Mohamed O. Abdel-Malek ◽  
Mohamed A. Mekky ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lymphocyte Subsets ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Egyptian Patients

MAGE-3 and MAGE-4 genes as possible markers for early detection of metastases in hepatitis C virus Egyptian patients complicated by hepatocellular carcinoma

2011 ◽  
Vol 29 (2) ◽  
pp. 994-999 ◽  
Author(s):  
Yousri M. Hussein ◽  
Amal F. Ghareib ◽  
Randa H. Mohamed ◽  
Mohamed I. Radwan ◽  
Wael H. Elsawy
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Early Detection ◽  
Egyptian Patients

scholarly journals TP53 polymorphism as a risk factor for hepatocellular carcinoma in hepatitis C virus-infected Egyptian patients

2014 ◽  
Vol 1 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Mustafa A. Neamatallah ◽  
Mohamed Amr El-Missiry ◽  
Muhamad M.A. Said ◽  
Mahmoud Elbendary ◽  
Azza I. Othman ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Egyptian Patients ◽  
Tp53 Polymorphism

scholarly journals Analysis of Monocytic and Granulocytic Myeloid-Derived Suppressor Cells Subsets in Patients with Hepatitis C Virus Infection and Their Clinical Significance

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Gang Ning ◽  
Lanhui She ◽  
Lirong Lu ◽  
Ying Liu ◽  
Yingfu Zeng ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Clinical Significance ◽  
Suppressor Cells ◽  
Hcv Rna ◽  
Myeloid Derived Suppressor Cells ◽  
Hepatitis C Virus Infection ◽  
Cell Responses ◽  
Hla Dr ◽  
Healthy Donors

Myeloid-derived suppressor cells (MDSCs) have been shown to inhibit T-cell responses in many diseases, but, in hepatitis C virus (HCV) infected patients, MDSCs are still poorly studied. In this assay, we investigated the phenotype and frequency of two new populations of MDSCs denoted as monocytic and granulocytic MDSCs (M-MDSCs and G-MDSCs) in HCV infected patients and analyzed their clinical significance in these patients respectively. We found that the frequency of CD14+HLA-DR-/lowcells (M-MDSCs) from HCV infected patients (mean ± SE, 3.134% ± 0.340%) was significantly increased when compared to healthy controls (mean ± SE, 1.764% ± 0.461%) (Z= −2.438,P= 0.015), while there was no statistical difference between the frequency ofHLA-DR-/lowCD33+CD11b+CD15+(G-MDSCs) of HCV infected patients and healthy donors (0.201% ± 0.038% versus 0.096% ± 0.026%,P> 0.05), which suggested that HCV infection could cause the proliferation of M-MDSCs instead of G-MDSCs. Besides, we found that the frequency of M-MDSCs in HCV infected patients had certain relevance with age (r= 0.358,P= 0.003); patients older than 40 years old group (mean ± SE, 3.673% ± 0.456%) had a significantly higher frequency of M-MDSCs than that of age less than 40 years old group (mean ± SE, 2.363% ± 0.482%) (Z= −2.685,P= 0.007). The frequency of M-MDSCs, however, had no correlation with HCV RNA loads, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the level of liver inflammation degree.

scholarly journals Association between TP53 and MDM2 Gene Polymorphisms and Risk of Hepatocellular Carcinoma in Hepatitis C Virus among Egyptian Populations

2020 ◽  
pp. 148-156
Author(s):  
Ahmed Mohamed Zaky ◽  
Shaden Muawia Hanafy ◽  
Magdy Mamdouh El- Bordiny ◽  
Reham Abdel Haleem Abu El- Wafa
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Tumor Suppressor ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Tumor Suppressor Protein ◽  
Mdm2 Snp309 ◽  
Mdm2 Gene ◽  
Egyptian Patients

Background: The Murine double minute 2 (MDM2) gene is overexpressed in several human tumors. The oncogenic potential of MDM2 is partially explained by inhibition of the activity of the tumor suppressor protein P53 (negative regulator of the P53 tumor suppressor protein). A single nucleotide polymorphism (SNP) in the promoter region of MDM2 gene (T to G exchange at nucleotide 309) and TP53 gene (codon 72 exon 4, rs1042522 encoding either C or G) have been independently associated with increased risk of several cancer types. Few studies have analyzed the role of these polymorphisms in the development of hepatocellular carcinoma among Egyptian patients with chronic hepatitis C virus infection. Methods: The study consisted in the comparison of the genotype distribution of TP53 and MDM2 SNP309 in 100 viral hepatitis C-related hepatocellular carcinomas (HCC) cases and 100 controls without HCC matched for age, gender and ethnicity. PCR-RFLP (restriction fragment length polymorphism) and real time PCR methods were used to determine the genotype at the MDM2 SNP309T>G locus and TP53 rs1042522. Results: Overall, our results indicate that frequencies of TP53 alleles (C and G) were not significant different between HCC cases and healthy controls (p=0.093) (Odds Ratio, OR=1.361,95% Confidence Interval, 95% CI=0.949 – 1.951). A significant increase of MDM2 SNP309 G/G and T/G genotypes were observed among HCC cases (Odds Ratio, OR=4.868, 95% Confidence Interval, 95% CI= 2.873 – 8.251). Conclusions: Our finding suggest that people who have G allele increase the risk by 4.868 folds for developing HCC among Egyptian patients, consequently the MDM2 309T>G polymorphism is an important modulator of hepatocellular carcinoma development in Egyptian patients.

Diagnostic Value of MicroRNA (miR-122) in Hepatitis C Virus (HCV)-related Hepatocellular Carcinoma (HCC) in Egyptian Patients

2017 ◽  
Vol 18 (5) ◽  
pp. 1-9
Author(s):  
Hatim El-Baz ◽  
Ahmed Elharoun ◽  
Tarek Hodhod ◽  
Ali Amin ◽  
Mostafa Abo-Zeid ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Diagnostic Value ◽  
Egyptian Patients
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