Evaluation of Varicella-zoster virus-specific cell-mediated immunity by interferon-γ Enzyme-Linked Immunosorbent Assay in adults ≥50 years of age administered a herpes zoster vaccine

2019 ◽  
Vol 91 (5) ◽  
pp. 829-835
Author(s):  
Ping Yang ◽  
Zhen Chen ◽  
Jieqiong Zhang ◽  
Wei Li ◽  
Changlin Zhu ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Immunosorbent Assay ◽  
Interferon Γ ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cell Mediated Immunity ◽  
Specific Cell ◽  
Zoster Vaccine ◽  
Varicella Zoster

scholarly journals Measurement of Varicella‐Zoster Virus (VZV)–Specific Cell‐Mediated Immunity: Comparison between VZV Skin Test and Interferon‐γ Enzyme‐Linked Immunospot Assay

2008 ◽  
Vol 198 (9) ◽  
pp. 1327-1333 ◽  
Author(s):  
Kay Sadaoka ◽  
Shigefumi Okamoto ◽  
Yasuyuki Gomi ◽  
Takeshi Tanimoto ◽  
Toyokazu Ishikawa ◽  
...  
Keyword(s):  
Varicella Zoster Virus ◽  
Skin Test ◽  
Interferon Γ ◽  
Cell Mediated Immunity ◽  
Specific Cell ◽  
Varicella Zoster

scholarly journals Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine

2018 ◽  
Vol 219 (2) ◽  
pp. 335-338 ◽  
Author(s):  
Adriana Weinberg ◽  
Zoran Popmihajlov ◽  
Kenneth E Schmader ◽  
Michael J Johnson ◽  
Yupanqui Caldas ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Cell Mediated Immunity ◽  
Zoster Vaccine ◽  
Varicella Zoster

Varicella-zoster virus-specific cell-mediated immunity in subjects with herpes zoster

2012 ◽  
Vol 377 (1-2) ◽  
pp. 53-55 ◽  
Author(s):  
Naruhito Otani ◽  
Kiyofumi Yamanishi ◽  
Yoshiko Sakaguchi ◽  
Yasutomo Imai ◽  
Masayuki Shima ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Cell Mediated Immunity ◽  
Specific Cell ◽  
Varicella Zoster

scholarly journals Varicella-Zoster Virus-Specific Enzyme-Linked Immunospot Assay Responses and Zoster-Associated Pain in Herpes Zoster Subjects

2012 ◽  
Vol 19 (9) ◽  
pp. 1411-1415 ◽  
Author(s):  
Stephen K. Tyring ◽  
Jon E. Stek ◽  
Jeffrey G. Smith ◽  
Jin Xu ◽  
Marco Pagnoni ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Pain Score ◽  
Geometric Mean ◽  
Age Groups ◽  
Brief Pain Inventory ◽  
Cell Mediated Immunity ◽  
Specific Cell ◽  
Varicella Zoster ◽  
Ifn Γ

ABSTRACTVaricella-zoster virus (VZV)-specific cell-mediated immunity (CMI) responses were compared over time following an episode of herpes zoster (HZ) with those of age-, race-, and gender-matched healthy controls (HC) without HZ, using a validated gamma interferon (IFN-γ) enzyme-linked immunospot (ELISPOT) assay. The zoster brief-pain inventory (ZBPI) was used to assess zoster-associated pain. HZ patients (n= 140) had significantly higher IFN-γ ELISPOT responses to VZV antigen than did HC (n= 140). ELISPOT geometric mean count (GMC) responses (with 95% confidence intervals [CI]) for subjects who presented within 72 h were as follows: for HZ patients ≥ 60 years of age, at day 0 the GMC was 110 and at week 2 the GMC was 235; for HZ patients 21 to 59 years of age, at day 0 the GMC was 111 and at week 2 the GMC was 198; for HC ≥ 60 years of age, at day 0 the GMC was 19 and at week 2 the GMC was 18; and for HC 21 to 59 years of age, at day 0 the GMC was 59 and at week 2 the GMC was 56. The mean pain score (95% CI) across age groups at 1 week postrash (n= 106) was 6.0 (5.5, 6.5) and at 2 weeks postrash (n= 119) was 3.5 (2.9, 4.0). The percentage of HZ patients with substantial pain (score ≥ 3) at 6 weeks postrash increased with age from 8% for patients 21 to 49 years of age to 16% for patients 50 to 59 years of age to 22% for patients ≥ 60 years of age. The VZV-specific CMI response was substantially boosted by an episode of HZ, as measured by ELISPOT results. Older adults had lower VZV-specific cellular immunity than younger subjects at baseline, but the boosting effect of HZ was substantial for all age groups. HZ patients experienced considerable zoster-associated acute (1 to 2 weeks after rash) pain across age groups, while chronic pain increased with age.

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