scholarly journals Antiviral activity of porcine interferon omega 7 against foot‐and‐mouth disease virus in vitro

2018 ◽  
Vol 91 (2) ◽  
pp. 208-214 ◽  
Author(s):  
Shi‐Fang Li ◽  
Fu‐Rong Zhao ◽  
Mei‐Jiao Gong ◽  
Jun‐Jun Shao ◽  
Yin‐Li Xie ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Proteogenomics Uncovers Critical Elements of Host Response in Bovine Soft Palate Epithelial Cells Following In Vitro Infection with Foot-And-Mouth Disease Virus

Viruses ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 53 ◽  
Author(s):  
Florian Pfaff ◽  
Sara Hägglund ◽  
Martina Zoli ◽  
Sandra Blaise-Boisseau ◽  
Eve Laloy ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Antiviral Activity ◽  
Disease Virus ◽  
Soft Palate ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Transcriptional Responses ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Foot-and-mouth disease (FMD) is the most devastating disease of cloven-hoofed livestock, with a crippling economic burden in endemic areas and immense costs associated with outbreaks in free countries. Foot-and-mouth disease virus (FMDV), a picornavirus, will spread rapidly in naïve populations, reaching morbidity rates of up to 100% in cattle. Even after recovery, over 50% of cattle remain subclinically infected and infectious virus can be recovered from the nasopharynx. The pathogen and host factors that contribute to FMDV persistence are currently not understood. Using for the first time primary bovine soft palate multilayers in combination with proteogenomics, we analyzed the transcriptional responses during acute and persistent FMDV infection. During the acute phase viral RNA and protein was detectable in large quantities and in response hundreds of interferon-stimulated genes (ISG) were overexpressed, mediating antiviral activity and apoptosis. Although the number of pro-apoptotic ISGs and the extent of their regulation decreased during persistence, some ISGs with antiviral activity were still highly expressed at that stage. This indicates a long-lasting but ultimately ineffective stimulation of ISGs during FMDV persistence. Furthermore, downregulation of relevant genes suggests an interference with the extracellular matrix that may contribute to the skewed virus-host equilibrium in soft palate epithelial cells.

scholarly journals Antiviral activity of brequinar against foot-and-mouth disease virus infection in vitro and in vivo

2019 ◽  
Vol 116 ◽  
pp. 108982 ◽  
Author(s):  
Shi-fang Li ◽  
Mei-jiao Gong ◽  
Yue-feng Sun ◽  
Jun-jun Shao ◽  
Yong-guang Zhang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Antiviral Activity ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Antiviral activity of merimepodib against foot and mouth disease virus in vitro and in vivo

2019 ◽  
Vol 114 ◽  
pp. 226-232
Author(s):  
Shi-fang Li ◽  
Mei-jiao Gong ◽  
Jun-jun Shao ◽  
Yue-feng Sun ◽  
Yong-guang Zhang ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals A novel type I interferon, interferon alphaomega, shows antiviral activity against foot-and-mouth disease virus in vitro

2019 ◽  
Vol 127 ◽  
pp. 79-84 ◽  
Author(s):  
Shi-fang Li ◽  
Mei-jiao Gong ◽  
Yin-li Xie ◽  
Jun–jun Shao ◽  
Fu-rong Zhao ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Disease Virus ◽  
Type I Interferon ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Type I ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Antiviral activity of porcine interferon delta 8 against foot-and-mouth disease virus in vitro

2018 ◽  
Vol 59 ◽  
pp. 47-52 ◽  
Author(s):  
Shi-fang Li ◽  
Jun-jun Shao ◽  
Fu-rong Zhao ◽  
Mei-jiao Gong ◽  
Yin-li Xie ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Factors Required for the Uridylylation of the Foot-and-Mouth Disease Virus 3B1, 3B2, and 3B3 Peptides by the RNA-Dependent RNA Polymerase (3Dpol) In Vitro

2005 ◽  
Vol 79 (12) ◽  
pp. 7698-7706 ◽  
Author(s):  
Arabinda Nayak ◽  
Ian G. Goodfellow ◽  
Graham J. Belsham
Keyword(s):  
Rna Polymerase ◽  
Disease Virus ◽  
Rna Synthesis ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coding Region ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Positive Strand Rna

ABSTRACT The 5′ terminus of picornavirus genomic RNA is covalently linked to the virus-encoded peptide 3B (VPg). Foot-and-mouth disease virus (FMDV) is unique in encoding and using 3 distinct forms of this peptide. These peptides each act as primers for RNA synthesis by the virus-encoded RNA polymerase 3Dpol. To act as the primer for positive-strand RNA synthesis, the 3B peptides have to be uridylylated to form VPgpU(pU). For certain picornaviruses, it has been shown that this reaction is achieved by the 3Dpol in the presence of the 3CD precursor plus an internal RNA sequence termed a cis-acting replication element (cre). The FMDV cre has been identified previously to be within the 5′ untranslated region, whereas all other picornavirus cre structures are within the viral coding region. The requirements for the in vitro uridylylation of each of the FMDV 3B peptides has now been determined, and the role of the FMDV cre (also known as the 3B-uridylylation site, or bus) in this reaction has been analyzed. The poly(A) tail does not act as a significant template for FMDV 3B uridylylation.

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