Human cytomegalovirus (HCMV)-specific T cell but not neutralizing or IgG binding antibody responses to glycoprotein complexes gB, gHgLgO, and pUL128L correlate with protection against high HCMV viral load reactivation in solid-organ transplant recipients

2018 ◽  
Vol 90 (10) ◽  
pp. 1620-1628 ◽  
Author(s):  
Daniele Lilleri ◽  
Paola Zelini ◽  
Chiara Fornara ◽  
Federica Zavaglio ◽  
Teresa Rampino ◽  
...  
Keyword(s):  
Viral Load ◽  
Human Cytomegalovirus ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Antibody Responses ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Igg Binding ◽  
Binding Antibody ◽  
Solid Organ Transplant Recipients

scholarly journals Long-Term Persistence of Immunoglobulin A (IgA) and IgM Antibodies against Human Cytomegalovirus in Solid-Organ Transplant Recipients

1999 ◽  
Vol 6 (4) ◽  
pp. 621-623 ◽  
Author(s):  
Bodo R. Eing ◽  
Horst G. Baumeister ◽  
Joachim E. Kuehn ◽  
Guenter May
Keyword(s):  
Human Cytomegalovirus ◽  
Immunoglobulin A ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

ABSTRACT The retrospective analysis of 494 solid-organ transplant recipients revealed that during the follow-up period (mean duration, 3.2 years) 184 (88%) of 209 anti-human cytomegalovirus (HCMV) immunoglobulin A (IgA)-positive patients remained IgA positive, as did 128 (74.85%) of 171 anti-HCMV IgM-positive patients. We conclude that anti-HCMV IgA and IgM testing for management of clinically relevant HCMV infections in solid-organ transplant recipients is dispensable.

scholarly journals SARS‐CoV‐2 antibody responses in solid organ transplant recipients

2021 ◽  
Author(s):  
Fainareti N. Zervou ◽  
Nicole M. Ali ◽  
Henry J. Neumann ◽  
Rebecca Pellett Madan ◽  
Sapna A. Mehta
Keyword(s):  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Antibody Responses ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

scholarly journals Rising Levels of Human Cytomegalovirus (HCMV) Antigenemia during Initial Antiviral Treatment of Solid-Organ Transplant Recipients with Primary HCMV Infection

1998 ◽  
Vol 36 (4) ◽  
pp. 1113-1116 ◽  
Author(s):  
Giuseppe Gerna ◽  
Maurizio Zavattoni ◽  
Elena Percivalle ◽  
Paolo Grossi ◽  
Maria Torsellini ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Hcmv Infection ◽  
Antiviral Treatment ◽  
Antiviral Drug ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

In 7 of 18 solid-organ transplant recipients with primary human cytomegalovirus (HCMV) infection, HCMV antigenemia levels were unexpectedly found to rise significantly (P = 0.018) during a mean time of 7.3 ± 3.2 days after initiation of specific antiviral treatment, whereas corresponding levels of viremia dropped significantly (P = 0.043). Thus, shifting to an alternative antiviral drug based solely on increasing antigenemia levels is not justified in this group of patients.

Sign in / Sign up

Export Citation Format

Share Document