MCPIP1 attenuates the innate immune response to influenza A virus by suppressing RIG-I expression in lung epithelial cells

2017 ◽  
Vol 90 (2) ◽  
pp. 204-211 ◽  
Author(s):  
Xiaoning Sun ◽  
Wenjing Feng ◽  
Yidi Guo ◽  
Qi Wang ◽  
Chunyan Dong ◽  
...  
Keyword(s):  
Immune Response ◽  
Epithelial Cells ◽  
Influenza A Virus ◽  
Innate Immune Response ◽  
Influenza A ◽  
Innate Immune ◽  
Lung Epithelial Cells ◽  
Lung Epithelial

scholarly journals MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

Cell Reports ◽  
2021 ◽  
Vol 34 (2) ◽  
pp. 108628 ◽  
Author(s):  
Xin Yin ◽  
Laura Riva ◽  
Yuan Pu ◽  
Laura Martin-Sancho ◽  
Jun Kanamune ◽  
...  
Keyword(s):  
Immune Response ◽  
Epithelial Cells ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Lung Epithelial Cells ◽  
Lung Epithelial

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

2020 ◽  
Author(s):  
Xin Yin ◽  
Laura Riva ◽  
Yuan Pu ◽  
Laura Martin-Sancho ◽  
Jun Kanamune ◽  
...  
Keyword(s):  
Immune Response ◽  
Epithelial Cells ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Lung Epithelial Cells ◽  
Lung Epithelial

scholarly journals Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus

2004 ◽  
Vol 280 (7) ◽  
pp. 5571-5580 ◽  
Author(s):  
Loïc Guillot ◽  
Ronan Le Goffic ◽  
Sarah Bloch ◽  
Nicolas Escriou ◽  
Shizuo Akira ◽  
...  
Keyword(s):  
Immune Response ◽  
Epithelial Cells ◽  
Influenza A Virus ◽  
Influenza A ◽  
Lung Epithelial Cells ◽  
Toll Like Receptor ◽  
Double Stranded Rna ◽  
Lung Epithelial

scholarly journals Release of Macrophage Migration Inhibitory Factor and CXCL8/Interleukin-8 from Lung Epithelial Cells Rendered Necrotic by Influenza A Virus Infection

2002 ◽  
Vol 76 (18) ◽  
pp. 9298-9306 ◽  
Author(s):  
Ute Arndt ◽  
Gunther Wennemuth ◽  
Peter Barth ◽  
Marianne Nain ◽  
Yousef Al-Abed ◽  
...  
Keyword(s):  
Immune Response ◽  
Epithelial Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Macrophage Migration Inhibitory Factor ◽  
Lung Epithelial Cells ◽  
Macrophage Migration ◽  
Lung Epithelial ◽  
Influenza A Virus Infection

ABSTRACT Bronchiolar epithelial cells are the prime targets for influenza A virus infection. It still remains to be clarified which signals are generated from these cells to initiate an immune response. Among chemokines, viral infection of primary lung epithelial cells triggered exclusively the release of CXCL8/interleukin-8 (IL-8), which contrasts with our previous observation that influenza A virus induced in monocytes the expression of mononuclear-leukocyte-attracting chemokines and even suppressed the production of neutrophil-attracting chemokines. Therefore, we speculated that it may be advantageous for respiratory epithelial cells to release primarily neutrophil-attracting CXCL8/IL-8 since neutrophils rapidly remove necrotic debris and are the first line of defense against bacterial superinfections. This concept has also been supported by our finding that influenza A virus infection led to necrosis of lung epithelial cells. This is in striking contrast to previous studies where influenza A virus infection induced apoptosis in monocytes and epithelial cells from origins other than the lung. Thus, the cell type instead of the virus determines which death pathway will be followed. In addition to the release of CXCL8/IL-8, we obtained a massive release of macrophage migration inhibitory factor (MIF) from virus-infected lung cells. However, whereas the CXCL8/IL-8 secretion was accompanied by induced gene activation, the transcription rate of MIF remained unchanged during the infection course and the virus-induced MIF release was predominantly a discharge from intracellular stores, suggesting that MIF is passively released upon cell death. Despite virus induced necrosis, the passively liberated MIF remained bioactive. Considering the well-established immunostimulatory effects of MIF on different leukocyte subsets, is its very likely that enhanced levels of MIF may contribute to the host immune response during the acute phase of influenza A virus infection in humans.

MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: role of Hsp90 acetylation

2016 ◽  
Vol 8 (17) ◽  
pp. 2017-2031 ◽  
Author(s):  
Simona Panella ◽  
Maria Elena Marcocci ◽  
Ignacio Celestino ◽  
Sergio Valente ◽  
Clemens Zwergel ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Influenza A Virus ◽  
Virus Replication ◽  
Influenza A ◽  
Lung Epithelial Cells ◽  
Lung Epithelial

scholarly journals The NS1 Protein of Influenza A Virus Blocks RIG-I-Mediated Activation of the Noncanonical NF-κB Pathway and p52/RelB-Dependent Gene Expression in Lung Epithelial Cells

2012 ◽  
Vol 86 (18) ◽  
pp. 10211-10217 ◽  
Author(s):  
Andrea Rückle ◽  
Emanuel Haasbach ◽  
Ilkka Julkunen ◽  
Oliver Planz ◽  
Christina Ehrhardt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Influenza A Virus ◽  
Influenza A ◽  
Target Gene ◽  
Lung Epithelial Cells ◽  
Ns1 Protein ◽  
Antiviral Immune Response ◽  
Lung Epithelial ◽  
Infected Cells

Influenza A virus (IAV) infection of epithelial cells activates NF-κB transcription factors via the canonical NF-κB signaling pathway, which modulates both the antiviral immune response and viral replication. Since almost nothing is known so far about a function of noncanonical NF-κB signaling after IAV infection, we tested infected cells for activation of p52 and RelB. We show that the viral NS1 protein strongly inhibits RIG-I-mediated noncanonical NF-κB activation and expression of the noncanonical target gene CCL19.

scholarly journals Influenza A Virus Infection Induces Apical Redistribution of Na+, K+-ATPase in Lung Epithelial Cells In Vitro and In Vivo

2019 ◽  
Vol 61 (3) ◽  
pp. 395-398
Author(s):  
Christin Peteranderl ◽  
Irina Kuznetsova ◽  
Jessica Schulze ◽  
Martin Hardt ◽  
Emilia Lecuona ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Influenza A Virus Infection
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