Characterization of partial NS5B region among hepatitis C virus genotype 6 subtypes isolated from Thai blood donors

2016 ◽  
Vol 88 (10) ◽  
pp. 1785-1790
Author(s):  
Suriya Chaiwong ◽  
Anchalee Sistayanarain
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Donors ◽  
Ns5b Region ◽  
Virus Genotype

scholarly journals Characterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Bo Wang ◽  
Luise Krüger ◽  
Patrycja Machnowska ◽  
Amare Eshetu ◽  
Barbara Gunsenheimer-Bartmeyer ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hiv 1

Resistance characterization of ledipasvir and velpatasvir in hepatitis C virus genotype 4

2017 ◽  
Vol 25 (2) ◽  
pp. 134-143 ◽  
Author(s):  
G. Camus ◽  
B. Han ◽  
T. Asselah ◽  
D. Hsieh ◽  
H. Dvory-Sobol ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Genotype ◽  
Genotype 4

Characterization of full-length hepatitis C virus genotype 4 sequences

2007 ◽  
Vol 14 (5) ◽  
pp. 330-337 ◽  
Author(s):  
J. Timm ◽  
M. Neukamm ◽  
T. Kuntzen ◽  
A. Y. Kim ◽  
R. T. Chung ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Full Length ◽  
Virus Genotype ◽  
Genotype 4

222 Base Pairs in NS5B Region and the Determination of Hepatitis C Virus Genotype 6

Intervirology ◽  
2006 ◽  
Vol 49 (4) ◽  
pp. 224-229 ◽  
Author(s):  
Teeraporn Chinchai ◽  
Suwanna Noppornpanth ◽  
Kavita Bedi ◽  
Apiradee Theamboonlers ◽  
Yong Poovorawan
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Ns5b Region ◽  
Virus Genotype ◽  
Base Pairs

scholarly journals Characterization of Samples Identified as Hepatitis C Virus Genotype 1 without Subtype by Abbott RealTime HCV Genotype II Assay Using the New Abbott HCV GenotypePlusRUO Test

2015 ◽  
Vol 54 (2) ◽  
pp. 296-299 ◽  
Author(s):  
Camelia Mokhtari ◽  
Anne Ebel ◽  
Birgit Reinhardt ◽  
Sandra Merlin ◽  
Stéphanie Proust ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Region ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hcv Genotype ◽  
The Core ◽  
Hcv Genotyping ◽  
Genotype Ii

Hepatitis C virus (HCV) genotyping continues to be relevant for therapeutic strategies. Some samples are reported as genotype 1 (gt 1) without subtype by the Abbott RealTime HCV Genotype II (GT II) test. To characterize such samples further, the Abbott HCV GenotypePlusRUO (Plus) assay, which targets the core region for gt 1a, gt 1b, and gt 6 detection, was evaluated as a reflex test in reference to NS5B or 5′-untranslated region (UTR)/core region sequencing. Of 3,626 routine samples, results of gt 1 without subtype were received for 171 samples (4.7%), accounting for 11.5% of gt 1 specimens. The Plus assay and sequencing were applied to 98 of those samples. NS5B or 5′-UTR/core region sequencing was successful for 91/98 specimens (92.9%). Plus assay and sequencing results were concordant for 87.9% of specimens (80/91 samples). Sequencing confirmed Plus assay results for 82.6%, 85.7%, 100%, and 89.3% of gt 1a, gt 1b, gt 6, and non-gt 1a/1b/6 results, respectively. Notably, 12 gt 6 samples that had been identified previously as gt 1 without subtype were assigned correctly here; for 25/28 samples reported as “not detected” by the Plus assay, sequencing identified the samples as gt 1 with subtypes other than 1a/1b. The genetic variability of HCV continues to present challenges for the current genotyping platforms regardless of the applied methodology. Samples identified by the GT II assay as gt 1 without subtype can be further resolved and reliably characterized by the new Plus assay.

scholarly journals An expanded taxonomy of hepatitis C virus genotype 6: Characterization of 22 new full-length viral genomes

Virology ◽  
2015 ◽  
Vol 476 ◽  
pp. 355-363 ◽  
Author(s):  
Chunhua Li ◽  
Eleanor Barnes ◽  
Paul N. Newton ◽  
Yongshui Fu ◽  
Manivanh Vongsouvath ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Full Length ◽  
Virus Genotype ◽  
Viral Genomes
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