Sensitivity of APTIMA HPV E6/E7 mRNA test in comparison with hybrid capture 2 HPV DNA test for detection of high risk oncogenic human papillomavirus in 396 biopsy confirmed cervical cancers

2016 ◽  
Vol 88 (7) ◽  
pp. 1271-1278 ◽  
Author(s):  
Partha Basu ◽  
Dipanwita Banerjee ◽  
Srabani Mittal ◽  
Sankhadeep Dutta ◽  
Ishita Ghosh ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Hybrid Capture ◽  
Dna Test ◽  
Hpv Dna ◽  
Cervical Cancers ◽  
Hpv E6 ◽  
Hybrid Capture 2 ◽  
Hpv Dna Test

scholarly journals Sensitivity, Specificity, and Clinical Value of Human Papillomavirus (HPV) E6/E7 mRNA Assay as a Triage Test for Cervical Cytology and HPV DNA Test

2011 ◽  
Vol 49 (7) ◽  
pp. 2643-2650 ◽  
Author(s):  
Maria Benevolo ◽  
Amina Vocaturo ◽  
Donatella Caraceni ◽  
Deborah French ◽  
Sandra Rosini ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Cytology ◽  
Clinical Value ◽  
Dna Test ◽  
Hpv Dna ◽  
Hpv E6 ◽  
Sensitivity Specificity ◽  
Triage Test ◽  
Hpv Dna Test

scholarly journals A prospective study of women with ASCUS or LSIL pap smears at baseline and HPV E6/E7 mRNA positive: a 3-year follow-up

2018 ◽  
Vol 146 (5) ◽  
pp. 612-618 ◽  
Author(s):  
M. T. Bruno ◽  
M. Ferrara ◽  
V. Fava ◽  
G. Barrasso ◽  
M. M. Panella
Keyword(s):  
High Risk ◽  
Prospective Study ◽  
Messenger Rna ◽  
Low Grade ◽  
Dna Test ◽  
Hpv Dna ◽  
Hpv E6 ◽  
Hpv Test ◽  
Hpv Dna Test

AbstractHuman papillomavirus (HPV) testing is used in the triage of women with a borderline smear result. The efficiency of testing women with a low-grade squamous intraepithelial lesion (LSIL) and atypical squamous cells of undetermined significance (ASCUS) is less clear. For this reason we used a new HPV test that detects E6/E7 messenger RNA (mRNA), which might have a higher specificity. The objective of this prospective study was to assess whether HPV E6/E7 mRNA positivity in women with ASCUS and LSIL at baseline, is able to predict those women who have a high risk of developing a histological cervical intraepithelial neoplasia (CIN2) or worse lesion. We took into consideration the women's age and HPV DNA genotype and followed them up for 3 years. Cervical samples from women with high-risk HPV (HR-HPV) DNA-positive ASCUS (n = 90) or LSIL (n = 222) were tested for the presence of HR-HPV E6/E7 mRNA and the women were monitored for the development of histopathologically verified CIN2+. Thirteen patients with ASCUS and 17 with LSIL did not complete follow-up. All patients with LSIL and ASCUS, enrolled in this study, had confirmed lesions at the colposcopic examination. Follow-up was available for 312 women, 193 were positive in the HR-HPV DNA test and 93 had a HPV E6/E7 mRNA positive test. Finally, 22 women positive in the HPV DNA test for high-risk genotypes and with positive E6/E7 mRNA had a histologically confirmed CIN2+. Only two cases with negative HPV E6/E7 mRNA had CIN2+. The study shows that women positive in the HPV E6/E7 mRNA test have a greater risk of malignant progression of cervical lesions and therefore deserve greater attention and earlier check-ups.

Clinical Efficacy of High-risk HPV DNA Test Using Hybrid Capture System in Cervical Epithelial Cells

2000 ◽  
Vol 11 (2) ◽  
pp. 148
Author(s):  
Choon Mo Yang ◽  
Ju Taek Kweon ◽  
In Seck Jang ◽  
Jang Cheol Cho ◽  
Chul Um ◽  
...  
Keyword(s):  
High Risk ◽  
Epithelial Cells ◽  
Clinical Efficacy ◽  
Hybrid Capture ◽  
Dna Test ◽  
Hpv Dna ◽  
Cervical Epithelial Cells ◽  
High Risk Hpv ◽  
Hpv Dna Test
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