Genetic diversity of HIV-1 and transmitted drug resistance among newly diagnosed individuals with HIV infection in Hangzhou, China

2015 ◽  
Vol 87 (10) ◽  
pp. 1668-1676 ◽  
Author(s):  
Jiafeng Zhang ◽  
Zhihong Guo ◽  
Jiezhe Yang ◽  
Xiaohong Pan ◽  
Jun Jiang ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Hiv Infection ◽  
Transmitted Drug Resistance ◽  
Newly Diagnosed ◽  
Hiv 1

scholarly journals Transmitted drug resistance to Tenofovir/Emtricitabine among persons with newly diagnosed HIV infection in Shenyang city, Northeast China from 2016 to 2018

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhen Wang ◽  
Bin Zhao ◽  
Minghui An ◽  
Wei Song ◽  
Xue Dong ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Hiv Infection ◽  
Northeast China ◽  
Transmitted Drug Resistance ◽  
Newly Diagnosed ◽  
Resistance Mutations ◽  
Shenyang City ◽  
Subtype B ◽  
Recent Hiv Infection ◽  
Hiv 1

Abstract Background To assess transmitted drug resistance (TDR) to tenofovir (TDF)/emtricitabine (FTC), using as pre-exposure prophylaxis, among newly diagnosed human immunodeficiency virus-1 (HIV-1)-infected residents in Shenyang city, northeast China. Methods Demographic and epidemiological information of all newly diagnosed HIV-1 infected residents in Shenyang city from 2016 to 2018 were anonymously collected from the local HIV epidemic database. HIV-1 pol sequences were amplified from RNA in cryopreserved plasma samples and sequenced directly. Viral subtypes were inferred with phylogenetic analysis and drug resistance mutations (DRMs) were determined according to the Stanford HIVdb algorithm. Recent HIV infection was determined with HIV Limiting Antigen avidity electro immunoassay. Results A total of 2176 sequences (92.4%, 2176/2354) were obtained; 70.9% (1536/2167) were CRF01_AE, followed by CRF07_BC (18.0%, 391/2167), subtype B (4.7%, 102/2167), other subtypes (2.6%, 56/2167), and unique recombinant forms (3.8%, 82/2167). The prevalence of TDR was 4.9% (107/2167), among which, only 0.6% (13/2167) was resistance to TDF/FTC. Most of these subjects had CRF01_AE strains (76.9%, 10/13), were unmarried (76.9%, 10/13), infected through homosexual contact (92.3%, 12/13), and over 30 years old (median age: 33). The TDF/FTC DRMs included K65R (8/13), M184I/V (5/13), and Y115F (2/13). Recent HIV infection accounted for only 23.1% (3/13). Most cases were sporadic in the phylogenetic tree, except two CRF01_AE sequences with K65R (Bootstrap value: 99%). Conclusions The prevalence of TDR to TDF/FTC is low among newly diagnosed HIV-infected cases in Shenyang, suggesting that TDR may have little impact on the protective effect of the ongoing CROPrEP project in Shenyang city.

HIV‐1 genetic diversity and transmitted drug resistance among newly diagnosed HIV‐1 individuals in Jiangmen, China

2020 ◽  
Vol 92 (12) ◽  
pp. 3209-3218
Author(s):  
Xin Guan ◽  
Min Han ◽  
Zhiju Li ◽  
Lihua Wang ◽  
Donghe Zhang ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Transmitted Drug Resistance ◽  
Newly Diagnosed ◽  
Hiv 1

Moderate prevalence of transmitted drug resistance and high HIV-1 genetic diversity in patients from Mato Grosso State, Central Western Brazil

2011 ◽  
Vol 83 (8) ◽  
pp. 1301-1307 ◽  
Author(s):  
Adriana Santarém Ferreira ◽  
Ludimila Paula Vaz Cardoso ◽  
Mariane Martins de Araújo Stefani
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Transmitted Drug Resistance ◽  
Mato Grosso ◽  
Hiv 1

Transmitted drug resistance and type of infection in newly diagnosed HIV-1 individuals in Honduras

2010 ◽  
Vol 49 (4) ◽  
pp. 239-244 ◽  
Author(s):  
Wendy Murillo ◽  
Gabriela Paz-Bailey ◽  
Sonia Morales ◽  
Edgar Monterroso ◽  
Mayte Paredes ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Transmitted Drug Resistance ◽  
Newly Diagnosed ◽  
Hiv 1

HIV-1 transmitted drug resistance and genetic diversity among patients from Piauí State, Northeast Brazil

2015 ◽  
Vol 87 (5) ◽  
pp. 798-806 ◽  
Author(s):  
Maria Edileuza Soares Moura ◽  
Mônica Nogueira da Guarda Reis ◽  
Yanna Andressa Ramos Lima ◽  
Kelsen Dantas Eulálio ◽  
Ludimila Paula Vaz Cardoso ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Transmitted Drug Resistance ◽  
Northeast Brazil ◽  
Hiv 1

scholarly journals Prevalence and Molecular Epidemiology of Transmitted Drug Resistance and Genetic Transmission Networks Among Newly Diagnosed People Living With HIV/AIDS in a Minority Area, China

2021 ◽  
Vol 9 ◽  
Author(s):  
Dan Yuan ◽  
Bin Yu ◽  
Yiping Li ◽  
Zixin Wang ◽  
Meijing Liu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Molecular Epidemiology ◽  
Transmitted Drug Resistance ◽  
People Living With Hiv ◽  
Newly Diagnosed ◽  
Transmission Networks ◽  
Genetic Transmission ◽  
Living With Hiv ◽  
Hiv 1 ◽  
Minority Area

Introduction: Transmitted drug resistance (TDR) can compromise antiretroviral therapy (ART) efficacy. We aimed to understand the molecular epidemiology of TDR and its genetic transmission networks among newly diagnosed people living with HIV/AIDS (PLWH).Methods: A total of 1,318 newly diagnosed PLWH, identified in all population-based HIV screening in an HIV-affected county of a minority area of China (i.e., Butuo county), were enrolled between January 1, 2018, and November 31, 2018. HIV-1 pol gene sequences were used for phylogenetic and genotypic drug resistance analyses. The genetic transmission networks were identified.Results: The prevalence of TDR among newly diagnosed PLWH was 8.12% (107/1,318). Patients in the stage of AIDS (adjusted odds ratio, OR: 2.32) and who had a history of sharing a needle ≥5 times (adjusted OR: 3.89) were more likely to have an increased risk of TDR. The prevalence of TDR for non-nucleoside reverse transcriptase inhibitors (NNRTIs) is higher than that of other inhibitors, with a relatively high prevalence of three mutations [V179D/E/DE (4.93%), K103N/KN (3.11%), and E138A/G (1.52%)]. A total of 577 (43.78%) pol sequences were involved in the genetic transmission network, with 171 clusters ranging in size from 2 to 91 pol sequences; 37.38% (40/107) of individuals carrying TDR were involved in the network, and individuals with the same TDR-associated mutations were usually cross-linked.Conclusions: Our data suggest a relatively high level of TDR and many transmission clusters among the newly diagnosed PLWH. Targeted intervention, early identification, and monitoring of resistance are warranted to reduce the TDR and prevent HIV-1 transmission in areas with a high rate of HIV-1.

scholarly journals Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals — China, 2015 and 2018

2021 ◽  
Vol 3 (53) ◽  
pp. 1133-1138
Author(s):  
Jingjing Hao ◽  
◽  
Shan Zheng ◽  
Mengze Gan ◽  
Aobo Dong ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Transmitted Drug Resistance ◽  
Newly Diagnosed ◽  
Hiv 1 ◽  
Hiv Aids

scholarly journals Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola

PLoS ONE ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. e0225251 ◽  
Author(s):  
Cruz S. Sebastião ◽  
Zoraima Neto ◽  
Carlos S. de Jesus ◽  
Marinela Mirandela ◽  
Domingos Jandondo ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Pregnant Women ◽  
Newly Diagnosed ◽  
Hiv 1

Alarming rate of transmitted drug resistance mutations and genetic diversity in newly HIV-1-infected patients in Benin

2020 ◽  
Author(s):  
Edmond Tchiakpe ◽  
Rene K Keke ◽  
Nicole Vidal ◽  
Clément Ahoussinou ◽  
Olga Sekpe ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Resistance Rate ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
High Genetic Diversity ◽  
Drug Resistance Mutations ◽  
Primary Drug Resistance ◽  
Hiv 1 ◽  
Primary Drug

Abstract BackgroundSeventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV naïve patients and HIV-1 genetic diversity were investigated in Benin.Methods353 plasma samples were collected between October and December 2017 in nineteen facilities care in Benin from HIV-1 positive and ARV naive individuals. Pol (protease + partial RT) region was amplified and sequenced in 248 samples.ResultsDrug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with predominance of mutations directed to NNRTIs drugs (24/248; 10%).Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV naïve patients.ConclusionsOur study showed a high primary drug resistance rate and a complex genetic diversity. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

HIV-1 Genetic Diversity and Transmitted Drug Resistance Mutations in Female Sex Workers from a Brazilian Municipality in the Amazon Region

2020 ◽  
Vol 36 (2) ◽  
pp. 99-100 ◽  
Author(s):  
Luana Mota da Costa ◽  
Paula Cristina R. Frade ◽  
Lucinaldo da Silva Blandtt ◽  
Gláucia C. Silva-Oliveira ◽  
Luiz Fernando A. Machado ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Sex Workers ◽  
Female Sex Workers ◽  
Amazon Region ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Female Sex ◽  
Hiv 1
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