Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran

2015 ◽  
Vol 87 (9) ◽  
pp. 1565-1572 ◽  
Author(s):  
Katayoun Samimi-Rad ◽  
Farzin Sadeghi ◽  
Aliakbar Amirzargar ◽  
Mohamad Reza Eshraghian ◽  
Seyed-Moayed Alavian ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Class Ii ◽  
Hla Class Ii ◽  
Virus Clearance ◽  
Hla Class Ii Alleles

scholarly journals Natural clearance of hepatitis C virus in hemophilia patients

Medicina ◽  
2007 ◽  
Vol 44 (1) ◽  
pp. 15 ◽  
Author(s):  
Raimonds Simanis ◽  
Sandra Lejniece ◽  
Arturs Sochnevs ◽  
Jelena Eglite ◽  
Gunta Chernevska ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Leukocyte ◽  
Class Ii ◽  
Hla Class Ii ◽  
Hcv Infection ◽  
Control Group ◽  
Hcv Rna ◽  
Pcr Method ◽  
Hla Class Ii Alleles

Objective. The objective of this study was to investigate the prevalence of HCV (hepatitis C virus) infection in hemophilia patients in Latvia and to analyze association between natural clearance of HCV and human leukocyte antigen (HLA) class II genes. Material and methods. From 61 hemophilic patients participating in this study, 38 were adults and 23 were pediatric patients younger than 18 years. To analyze association between HLA class II alleles and natural clearance of HCV, the gene frequency was compared in hemophilia patients group and the control group of 60 healthy subjects, all men. Serum HCV RNA was qualitatively determined and HLA class II alleles were identified by polymerase chain reaction (PCR) method. Results. HCV infection is common among hemophilia patients in Latvia. Antibodies to HCV were found in 45 of 61 (74%) hemophilia patients. In 41% of hemophilia patients (18 of 44), HCV infection resolved spontaneously. Children cleared HCV more frequently than adults (7 of 11 comparing to 11 of 33, respectively; OR=3.50; P<0.05). The frequency difference was found to be statistically significant when comparing HLA alleles distribution in the sample of hemophilia patients who naturally cleared HCV (n=18) and in the control group (n=60) (corresponding frequency of HLA-DRB1*07 allele – 4 (11.11%) and 9 (1.67%); OR=7.38; P<0.05). Conclusions. Natural clearance of HCV infection is frequently found in hemophilia patients in Latvia. Children are more likely to clear virus naturally than adults. There is an association between natural clearance of HCV and HLA allele DRB1*07 in hemophilia patients.

scholarly journals HLA Class II Alleles and Chronic Hepatitis C Virus Infection

2011 ◽  
Vol 74 (3) ◽  
pp. 282-287 ◽  
Author(s):  
L. O. F. Cangussu ◽  
R. Teixeira ◽  
E. F. Campos ◽  
G. F. Rampim ◽  
S. A. Mingoti ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Class Ii ◽  
Hla Class Ii ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus ◽  
Hla Class Ii Alleles

scholarly journals Association of HLA Class II Alleles with Outcome of Hepatitis C Virus Infection: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 21 (7) ◽  
Author(s):  
Hossein Ghaderi-Zefrehi ◽  
Mohammad Gholami-Fesharaki ◽  
Amir Ghorbanzadeh ◽  
Farzin Sadeghi
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Class Ii ◽  
Hla Class Ii ◽  
Hcv Infection ◽  
Spontaneous Clearance ◽  
Antiviral Immune Response ◽  
Hla Dr ◽  
Hla Dq ◽  
Hla Class Ii Alleles

Context: Hepatitis C Virus (HCV) infection is a major cause of chronic cirrhosis and hepatocellular carcinoma. Approximately 30% of infected persons with HCV spontaneously clear the viral infection; but, some of the remaining patients develop chronic HCV. Studies show that HLA molecules play an important role in the outcome of HCV infection by influencing the efficiency of the antiviral immune response to HCV infection. It is now known that polymorphisms in HLA loci are associated with HCV susceptibility or clearance. The purpose of the present study was to systematically review the studies that reported the association of HLA class II alleles (HLA-DQ and HLA-DR) with the outcome of HCV infection. Evidence Acquisition: Studies were identified by searching electronic databases, including PubMed and Scopus. A total of 12,265 relevant studies were identified by the electronic search, of which a total of 19 eligible papers were identified that were meta-analyzed for the association between HLA class II alleles and the outcome of HCV infection. Results: Subjects carrying HLA-DQB1*0301, HLA-DQB1*0501, HLA-DRB1*1303, HLA-DRB1*1201, HLA-DRB1*0401, HLA-DRB1*0101, and HLA-DRB1*1101 alleles were significantly associated with higher spontaneous clearance of HCV infection. Conclusions: The data from the current study confirm that several polymorphisms in HLA-DQ and HLA-DR loci are correlated with the clearance of HCV infection. Identifying these polymorphisms may contribute to a better understanding of immune mechanisms of HCV clearance or persistence.

scholarly journals Intrahepatic and circulating HLA class II-restricted, hepatitis C virus-specific T cells: Functional characterization in patients with chronic hepatitis C

Hepatology ◽  
2002 ◽  
Vol 35 (5) ◽  
pp. 1225-1236 ◽  
Author(s):  
Amalia Penna ◽  
Gabriele Missale ◽  
Vincenzo Lamonaca ◽  
Massimo Pilli ◽  
Cristina Mori ◽  
...  
Keyword(s):  
T Cells ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Functional Characterization ◽  
Class Ii ◽  
Hla Class Ii

scholarly journals HLA class II alleles in Romanian patients with chronic hepatitis C

GERMS ◽  
2015 ◽  
Vol 5 (2) ◽  
pp. 44-49 ◽  
Author(s):  
Loredana Gheorghe ◽  
Sorin Rugină ◽  
Irina Magdalena Dumitru ◽  
Irina Franciuc ◽  
Alina Martinescu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Class Ii ◽  
Hla Class Ii ◽  
Hla Class Ii Alleles

scholarly journals Minimal T-Cell-Stimulatory Sequences and Spectrum of HLA Restriction of Immunodominant CD4+ T-Cell Epitopes within Hepatitis C Virus NS3 and NS4 Proteins

2005 ◽  
Vol 79 (19) ◽  
pp. 12425-12433 ◽  
Author(s):  
J. T. Gerlach ◽  
A. Ulsenheimer ◽  
N. H. Grüner ◽  
M.-C. Jung ◽  
W. Schraut ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Acute Hepatitis ◽  
Patient Selection ◽  
Class Ii ◽  
Hla Class Ii ◽  
Acute Hepatitis C ◽  
T Cell Epitopes

ABSTRACT The hepatitis C virus (HCV)-specific CD4+ T-cell response against nonstructural proteins is strongly associated with successful viral clearance during acute hepatitis C. To further develop these observations into peptide-based vaccines and clinical immunomonitoring tools like HLA class II tetramers, a detailed characterization of immunodominant CD4+ T-cell epitopes is required. We studied peripheral blood mononuclear cells from 20 patients with acute hepatitis C using 83 overlapping 20-mer peptides covering the NS3 helicase and NS4. Eight peptides were recognized by ≥40% of patients, and specific CD4+ T-cell clones were obtained for seven of these and three additional, subdominant epitopes. Mapping of minimal stimulatory sequences defined epitopes of 8 to 13 amino acids in length, but optimal T-cell stimulation was observed with 10- to 15-mers. While some epitopes were presented by different HLA molecules, others were presented by only a single HLA class II molecule, which has implications for patient selection in clinical trials of peptide-based immunotherapies. In conclusion, using two different approaches we identified and characterized a set of CD4+ T-cell epitopes in the HCV NS3-NS4 region which are immunodominant in patients achieving transient or persistent viral control. This information allows the construction of a valuable panel of HCV-specific HLA class II tetramers for further study of CD4+ T-cell responses in chronic hepatitis C. The finding of immunodominant epitopes with very constrained HLA restriction has implications for patient selection in clinical trials of peptide-based immunotherapies.

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