Full genome analysis of a European-type genotype 3 hepatitis E virus variant obtained from a Japanese patient with autochthonous acute hepatitis E

2015 ◽  
Vol 87 (7) ◽  
pp. 1067-1071 ◽  
Author(s):  
Suguru Takeuchi ◽  
Yuichi Yamazaki ◽  
Ken Sato ◽  
Daichi Takizawa ◽  
Masanobu Yamada ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Genome Analysis ◽  
Hepatitis E Virus ◽  
Japanese Patient ◽  
Hepatitis E ◽  
Full Genome ◽  
Genotype 3 ◽  
Virus Variant ◽  
Acute Hepatitis E ◽  
Full Genome Analysis

scholarly journals Full genome analysis of swine genotype 3 hepatitis E virus isolated from eastern China

2017 ◽  
Vol 18 (6) ◽  
pp. 549-554 ◽  
Author(s):  
Jiang-bing Shuai ◽  
Lu-huan Li ◽  
Ai-yun Li ◽  
Yong-qiang He ◽  
Xiao-feng Zhang
Keyword(s):  
Genome Analysis ◽  
Hepatitis E Virus ◽  
Eastern China ◽  
Hepatitis E ◽  
Full Genome ◽  
Genotype 3 ◽  
Full Genome Analysis

scholarly journals Hepatitis E virus in Italy: molecular analysis of travel-related and autochthonous cases

2011 ◽  
Vol 92 (7) ◽  
pp. 1617-1626 ◽  
Author(s):  
Giuseppina La Rosa ◽  
Michele Muscillo ◽  
Valentina Spuri Vennarucci ◽  
Anna Rosa Garbuglia ◽  
Patrizia La Scala ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
The Body ◽  
Industrialized Countries ◽  
Genotype 3 ◽  
Serum Samples ◽  
Specific Primers ◽  
Body Of Knowledge ◽  
Acute Hepatitis E

Human hepatitis E virus (HEV) is considered an emerging pathogen in industrialized countries. The aim of the present study was to contribute to the body of knowledge available on the molecular epidemiology of acute hepatitis E in Italy. Three sets of HEV-specific primers targeting the ORF1 and ORF2 were used to examine serum samples collected from acute hepatitis patients positive for anti-HEV IgG and/or IgM, between 2007 and 2010. Seventeen patients (39.5 %) tested HEV RNA-positive: 12 infections, due to genotype 1, were associated with travel to endemic areas (Bangladesh, India and Pakistan), while five infections, due to genotype 3, were presumably autochthonous. Risk factors identified in this group included exposure to raw seafood, pork liver sausages and wild boar. Results from the present study confirm that human HEV infection in Italy is caused by different genotypes, depending on whether the infection is travel-related or autochthonous.

Identification and a full genome analysis of novel camel hepatitis E virus strains obtained from Bactrian camels in Mongolia

2021 ◽  
pp. 198355
Author(s):  
Tsutomu Nishizawa ◽  
Masaharu Takahashi ◽  
Bira Tsatsralt-Od ◽  
Khurelbaatar Nyamdavaa ◽  
Nyamkhuu Dulmaa ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Full Genome ◽  
Bactrian Camels ◽  
Full Genome Analysis ◽  
Virus Strains

scholarly journals Neurologic complications of acute hepatitis E virus infection

2019 ◽  
Vol 7 (1) ◽  
pp. e643 ◽  
Author(s):  
Paolo Ripellino ◽  
Emanuela Pasi ◽  
Giorgia Melli ◽  
Claudio Staedler ◽  
Monserrat Fraga ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Elevated Serum ◽  
Shoulder Girdle ◽  
Hepatitis E ◽  
Immunoglobulin M ◽  
Genotype 3 ◽  
Neurologic Symptoms ◽  
Bilateral Involvement ◽  
Acute Hepatitis E

ObjectiveTo assess the prevalence and clinical features of neurologic involvement in patients with acute hepatitis E virus (HEV) infection in Southern Switzerland.MethodsAmong 1,940 consecutive patients investigated for acute hepatitis E, we identified 141 cases of acute of HEV infection (anti-HEV immunoglobulin M and immunoglobulin G both reactive and/or HEV RNA positive) between June 2014 and September 2017. Neurologic cases were followed up for 6 months. We compared patients with and without neurologic symptoms.ResultsNeurologic symptoms occurred in 43 acute HEV cases (30.4%) and consisted of neuralgic amyotrophy (NA, n = 15, 10.6%) and myalgia (n = 28, 19.8%). All NA cases were immunocompetent. Men had higher odds (OR = 5.2, CI 1.12–24.0, p = 0.03) of developing NA after infection with HEV, and in 3 couples simultaneously infected with HEV, only men developed NA. Bilateral involvement of NA was predominant (2:1) and occurred only in men. Seven NA cases were viremic (all genotype 3), but HEV was undetectable in their CSF. In the acute phase of NA, 9 patients were treated with intravenous immunoglobulin and 4 with prednisone, reporting no side effects and improvement in pain and strength. Myalgia occurred both without (n = 16) or with (n = 12) concomitant elevated serum creatinine kinase. Seven cases with myalgia in the shoulder girdle did not have muscle weakness (“forme fruste” of NA).ConclusionsNeurologic symptoms occurred in one-third of acute HEV infections and consisted of NA and myalgia. NA seems to occur more frequently in men infected by HEV and has a predominant (but not exclusive) bilateral involvement.

scholarly journals Four cases of sporadic acute hepatitis E in Mie, Japan who were infected with European type genotype 3 hepatitis E virus

Kanzo ◽  
2011 ◽  
Vol 52 (5) ◽  
pp. 295-302 ◽  
Author(s):  
Hiroshi Okano ◽  
Tatsunori Nakano ◽  
Shimpei Matsusaki ◽  
Tomohiro Sase ◽  
Tomonori Saitou ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 3 ◽  
Sporadic Acute Hepatitis ◽  
Acute Hepatitis E

scholarly journals Severe Acute Hepatitis E in a Woman with an Autoimmune Background

2020 ◽  
Vol 33 (6) ◽  
pp. 425
Author(s):  
Maria S.J. Nascimento ◽  
Madalena Almeida-Santos ◽  
Maria Fernandes ◽  
Fernando Maltez ◽  
Sara Lino ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Hepatic Necrosis ◽  
Coagulation Disorder ◽  
Genotype 3 ◽  
Virus Genotype ◽  
Younger Men ◽  
Acute Hepatitis E ◽  
Severe Acute Hepatitis

Hepatitis E virus genotype 3 infections are normally asymptomatic in immunocompetent individuals. Symptomatic cases of acute icteric hepatitis E are seldom observed among women, younger men and children but are particularly seen in middle-aged/elderly men. We report a case of severe acute hepatitis E caused by genotype 3 in an immunocompetent 40-year-old woman that required prolonged hospitalization. Her medical history included an autoimmune background, namely atrophic gastritis and Graves’ disease. She presented an extensive hepatic necrosis as revealed by the high levels of aminotransferases (ALT 4893 U/L; AST 3138 U/L). She showed also a coagulation disorder (prothrombin time; INR = 1.33). Serological markers for hepatitis viruses A, B and C were negative but serum was positive for hepatitis E virus RNA. Sequencing and phylogenetic analysis revealed that the hepatitis E virus strain belonged to subgenotype 3a. This is suggestive of an association between the severe acute hepatitis E virus genotype 3 infection and the autoimmune background.

Performance of an antigen assay for diagnosing acute hepatitis E virus genotype 3 infection

2016 ◽  
Vol 79 ◽  
pp. 1-5 ◽  
Author(s):  
Pauline Trémeaux ◽  
Sébastien Lhomme ◽  
Sabine Chapuy-Regaud ◽  
Jean-Marie Peron ◽  
Laurent Alric ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 3 ◽  
Virus Genotype ◽  
Antigen Assay ◽  
Acute Hepatitis E

scholarly journals Acute hepatitis E virus infection in human immunodeficiency virus-positive men and women in Nepal: Not quite a rare entity

Hepatology ◽  
2016 ◽  
Vol 64 (3) ◽  
pp. 1006-1007 ◽  
Author(s):  
Birendra Prasad Gupta ◽  
Ananta Shrestha ◽  
Anurag Adhikari ◽  
Thupten Kelsang Lama ◽  
Binaya Sapkota
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Rare Entity ◽  
Men And Women ◽  
Immunodeficiency Virus ◽  
Acute Hepatitis E
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