High prevalence of HHV8 infection and specific killer cell immunoglobulin-like receptors allotypes in Sardinian patients with type 2 diabetes mellitus

2013 ◽  
Vol 86 (10) ◽  
pp. 1745-1751 ◽  
Author(s):  
Elisabetta Caselli ◽  
Roberta Rizzo ◽  
Angela Ingianni ◽  
Pierpaolo Contini ◽  
Raffaello Pompei ◽  
...  
2001 ◽  
Vol 73 (3) ◽  
pp. 582-585 ◽  
Author(s):  
Gian Franco Meloni ◽  
Carla Colombo ◽  
Carlo La Vecchia ◽  
Adolfo Pacifico ◽  
Paolo Tomasi ◽  
...  

2020 ◽  
Vol 25 (6) ◽  
pp. 693-699
Author(s):  
E. N. Grineva ◽  
V. I. Mazurov ◽  
Yu. Sh. Khalimov ◽  
I. G. Bakulin ◽  
A. V. Panov ◽  
...  

Considering high prevalence of prediabetes, exceeding the incidence of type 2 diabetes mellitus, clear algorithms for identifying and managing patients with this pathology is the most important task for doctors of various specialties — therapeutists, cardiologists, general practitioners. The preventive measures are more efficient when started at the stage of prediabetes rather than when type 2 diabetes mellitus has been developed. They help to prevent or delay the development of type 2 diabetes mellitus, its micro- and macrovascular complications, cardiovascular diseases, pathology of muscular-skeletal system and liver. All these measures should be implemented at the stage of primary health care. The resolution presents an algorithm of verifying and management of prediabetes and type 2 diabetes mellitus.


2019 ◽  
Vol 10 ◽  
pp. 215013271988063 ◽  
Author(s):  
V. Samya ◽  
Vanishree Shriraam ◽  
Aliya Jasmine ◽  
G. V. Akila ◽  
M. Anitha Rani ◽  
...  

Introduction: One of the greatest threats to achieving tight glycemic control is hypoglycemia, which can lead to decreased drug compliance, cardiovascular events, and even mortality. There is lack of literature on this complication in the Indian setting. This study will aid the primary care physician to achieve better glycemic control of the diabetic patients and provide patient education to prevent hypoglycemia. Materials and Methods: It was a cross-sectional study in which 390 patients with type 2 diabetes mellitus getting treated in a primary health center were assessed for symptoms of hypoglycemia. Results: Prevalence of hypoglycemia was 57.44% (95% CI 52.48-62.25). Severe hypoglycemia was found in 10.7% of the patients. The first reported symptom of hypoglycemia was dizziness (72.3%). The most common etiological factor leading to hypoglycemia was missing a meal (89.3%). Females were at a significant higher risk of developing hypoglycemia (OR 1.2, 95% CI 1.04-1.3, P < .05). Conclusion: This study has established the high prevalence of self-reported hypoglycaemia in the rural settings where resources are limited to monitor the glucose levels. The high prevalence urges the need for the primary care physicians to enquire about the hypoglycemic symptoms to all diabetic patients at each visit. It is also important to educate these patients about the symptoms of hypoglycemia and the importance of reporting of such symptoms, which will help in adjusting dose and preventing future attacks.


2018 ◽  
Vol 54 ◽  
pp. 102-108 ◽  
Author(s):  
Chun-Jen Huang ◽  
Hui-Min Hsieh ◽  
Hung-Pin Tu ◽  
He-Jiun Jiang ◽  
Peng-Wei Wang ◽  
...  

AbstractBackground:This study investigated the prevalence and characteristics of schizophrenia in patients with type 2 diabetes mellitus (T2DM) in Taiwan.Methods:National Health Insurance claims data for patients with principal diagnoses of schizophrenia and T2DM were analysed.Results:Compared with patients with schizophrenia in the general population (GP), those with schizophrenia and T2DM were more likely to have higher Charlson comorbidity index (CCI) scores and multiple comorbidities, and were older. The prevalence of schizophrenia was significantly higher in patients with T2DM than in the GP from 2000 to 2010. In addition, during this period, the prevalence of schizophrenia in patients with T2DM increased from 0.64% to 0.85%; such an increase in the GP was also observed. A high prevalence of schizophrenia was observed in patients with T2DM aged less than 60 years old; those residing in eastern Taiwan; those with incomes of ≤NT$17,280, NT$17,281–NT$22,880, NT$22,881–NT$28,800, and NT$36,301–NT$45,800; and those with CCI > 2.Conclusions:Our study found the prevalence of schizophrenia is higher in patients with T2DM than in the GP, particularly those with earlier ages less than 60 years old. Public health initiatives are necessary to prevent and treat schizophrenia in patients with T2DM, specifically for those with the aforementioned and premature death risk.


Pancreas ◽  
2020 ◽  
Vol 49 (1) ◽  
pp. e5-e7 ◽  
Author(s):  
Kasper A. Overbeek ◽  
Nanda C. Krak ◽  
Indra C. Pieters ◽  
Mark M. Smits ◽  
Rosa M. Bent ◽  
...  

2017 ◽  
Vol 30 (10) ◽  
pp. 719
Author(s):  
Carlos Tavares Bello ◽  
Ricardo Miguel Capitão ◽  
João Sequeira Duarte ◽  
Jorge Azinheira ◽  
Carlos Vasconcelos

Introduction: Type 2 diabetes mellitus is a common disease, affecting up to 13.1% of the Portuguese population. In addition to the known micro and macrovascular complications, drug side effects constitute a major concern, leading to changes in the treatment guidelines, which favor safety over efficacy. Metformin is the first-line pharmacological treatment for most patients with type 2 diabetes mellitus; however, it has been associated with vitamin B12 deficiency in up to 30% of treated patients. The authors describe the prevalence of vitamin B12 deficiency in a diabetic population and explore the possible underlying factors.Material and Methods: Retrospective, observational study. Clinical and laboratory data of type 2 diabetes mellitus patients whose vitamin B12 status was evaluated in the last decade (2005 - 2016) were analyzed. Patients with known malabsorptive syndromes or having undergone bariatric surgery were excluded from the study. Statistical analysis of the data was done and the results were considered statistically significant at p values < 0.05.Results: The study included a total of 1007 patients (58% women) with a mean age of 66.4 ± 12.2 years and 11 ± 10.4 years of type 2 diabetes mellitus duration. These patients had a high prevalence of complications: diabetic renal disease 47.7%, neuropathy 9.2%, retinopathy 14.9%, coronary artery disease 8.4%, cerebrovascular disease 10.9%, and peripheral arterial disease 5.5%. Vitamin B12 deficiency (< 174 ng / dL) was present in 21.4% of the population and this subgroup was older (68.4 vs 65.8 years, p = 0.006), had a longer type 2 diabetes mellitus duration (13.35 vs 10.36 years; p = 0.001), higher prevalence of retinopathy (20.9% vs 13.3%; p = 0.005) and thyroid dysfunction (34% vs 23.7%; p = 0.002). Vitamin B12 deficiency was also more frequent in patients treated with metformin (24.7% vs 15.8%; p = 0.017), antiplatelet agents (25.4% vs 16.2%, p < 0.001), and calcium channel blockers (26.8% vs 18.2%; p = 0.001). After adjustment for possible confounders, the variables associated with B12 deficiency were: metformin, hypothyroidism, age and type 2 diabetes mellitus duration.Discussion: Despite the retrospective design, the results report a high prevalence of vitamin B12 deficiency in the type 2 diabetic population. This study also demonstrates that the B12 deficiency risk is higher in older people, with longer diabetes mellitus duration, hypothyroidism and treated with metformin.Conclusion: Further studies are needed to identify the risk factors for the B12 deficit. The recognition of these variables will contribute to optimize the screening and prevention of the B12 deficiency in type 2 diabetes mellitus.


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