Recurrence of another hepatitis B virus escape mutant comes back in a patient infected with HIV and low CD4+ count

2013 ◽  
Vol 86 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Laura Milazzo ◽  
Erika Ebranati ◽  
Dario Cattaneo ◽  
Elena Gabanelli ◽  
Alessia Lai ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cd4 Count ◽  
Escape Mutant ◽  
Virus Escape ◽  
B Virus ◽  
Virus Escape Mutant

scholarly journals A case of hepatitis B reactivation due to the hepatitis B virus escape mutant in a patient undergoing chemotherapy

2012 ◽  
Vol 27 (6) ◽  
pp. 368-371 ◽  
Author(s):  
Chunchen Wu ◽  
Hui Shi ◽  
Yun Wang ◽  
Mengji Lu ◽  
Yang Xu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Escape Mutant ◽  
Hepatitis B Reactivation ◽  
Virus Escape ◽  
B Virus ◽  
Virus Escape Mutant

Reactivation of an occult hepatitis B virus escape mutant in an anti-HBs positive, anti-HBc negative lymphoma patient

2007 ◽  
Vol 38 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Sabine Awerkiew ◽  
Martin Däumer ◽  
Marcel Reiser ◽  
Ulrike C. Wend ◽  
Herbert Pfister ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Escape Mutant ◽  
Lymphoma Patient ◽  
Occult Hepatitis ◽  
Virus Escape ◽  
B Virus ◽  
Occult Hepatitis B ◽  
Virus Escape Mutant

scholarly journals Hepatitis B virus "escape" mutants.

BMJ ◽  
1990 ◽  
Vol 301 (6760) ◽  
pp. 1058-1059
Author(s):  
D H Crawford
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Escape ◽  
B Virus ◽  
Escape Mutants

scholarly journals Genetic Characterization of Hepatitis B Virus in Peripheral Blood Leukocytes: Evidence for Selection and Compartmentalization of Viral Variants with the Immune Escape G145R Mutation

2009 ◽  
Vol 83 (19) ◽  
pp. 9983-9992 ◽  
Author(s):  
Sibnarayan Datta ◽  
Rajesh Panigrahi ◽  
Avik Biswas ◽  
Partha K. Chandra ◽  
Arup Banerjee ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Peripheral Blood ◽  
Immune Escape ◽  
Escape Mutant ◽  
Large Set ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Frequent Event ◽  
B Virus

ABSTRACT The compartmentalization of viral variants in distinct host tissues is a frequent event in many viral infections. Although hepatitis B virus (HBV) classically is considered hepatotropic, it has strong lymphotropic properties as well. However, unlike other viruses, molecular evolutionary studies to characterize HBV variants in compartments other than hepatocytes or sera have not been performed. The present work attempted to characterize HBV sequences from the peripheral blood leukocytes (PBL) of a large set of subjects, using advanced molecular biology and computational methods. The results of this study revealed the exclusive compartmentalization of HBV subgenotype Ae/A2-specific sequences with a potent immune escape G145R mutation in the PBL of the majority of the subjects. Interestingly, entirely different HBV genotypes/subgenotypes (C, D, or Aa/A1) were found to predominate in the sera of the same study populations. These results suggest that subgenotype Ae/A2 is selectively archived in the PBL, and the high prevalence of G145R indicates high immune pressure and high evolutionary rates of HBV DNA in the PBL. The results are analogous to available literature on the compartmentalization of other viruses. The present work thus provides evidence in favor of the compartment-specific abundance, evolution, and emergence of the potent immune escape mutant. These findings have important implications in the field of HBV molecular epidemiology, transmission, transfusion medicine, organ transplantation, and vaccination strategies.

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