scholarly journals Detection of multiple viral and bacterial infections in acute exacerbation of chronic obstructive pulmonary disease: A pilot prospective study

2013 ◽  
Vol 85 (5) ◽  
pp. 866-873 ◽  
Author(s):  
Jeanne-Marie Perotin ◽  
Sandra Dury ◽  
Fanny Renois ◽  
Gaëtan Deslee ◽  
Aurore Wolak ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Prospective Study ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Bacterial Infections ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

A prospective study on bacterial and atypical etiology of acute exacerbation in chronic obstructive pulmonary disease

2014 ◽  
Vol 9 (11) ◽  
pp. 1251-1260 ◽  
Author(s):  
Alexandra Nakou ◽  
Joseph Papaparaskevas ◽  
Filia Diamantea ◽  
Nikoletta Skarmoutsou ◽  
Vlasis Polychronopoulos ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Prospective Study ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
A Prospective Study

scholarly journals Detection of respiratory viruses and expression of inflammatory cytokines in patients with acute exacerbation chronic obstructive pulmonary disease in Mongolia China

2022 ◽  
Vol 82 ◽  
Author(s):  
Y. Feng ◽  
E. Liu
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Inflammatory Markers ◽  
Bacterial Infections ◽  
Smoking History ◽  
Severe Illness ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Tnf Α

Abstract Chronic obstructive pulmonary disease (COPD) was estimated to be the third cause of global mortality by 2020. Acute exacerbation COPD (AECOPD) is a sudden worsening of COPD symptoms and could be due to virus/bacterial infections and air pollution. Increased expression of inflammatory markers in patients with AECOPD is associated with viral infection. This study aimed to detect different viruses and analyze the expression of various inflammatory markers associated with AECOPD patients. Three hundred and forty-seven patients diagnosed with COPD according to GOLD criteria were included in this study. Swab samples and blood were collected for the detection of viruses by RT-PCR and expression of inflammatory markers, respectively. Of the swab samples, 113 (32.6%) of samples were positive for virus detection. Of these, HRV (39.8%) was the predominant virus detected followed by FluB (27.4%) and FluA (22.1%). The presence of HRV was significantly higher (p=0.044) among the other detected viruses. When compared to healthy controls the expression levels of TNF-α, IL-6 and IL-8 were significantly higher (p<0.05) in virus-positive patients. The IL-6 and IL-8 were the next predominantly expressed in markers among the samples. The higher expression rate of IL-8 was significantly (p<0.05) associated with patients having COPD GOLD III severity level and smoking history. Although HRV was the predominant virus detected the combined prevalence of Influenza A and B surpassing the rate of HRV. The high-level expression of well known inflammatory markers of AECOPD, TNF-α, IL-6 and IL-8 indicates a chronic severe illness. These markers play an important role and could be used as a marker for determining the severity of AECOPD.

scholarly journals Sequential Treatments with Tongsai and Bufei Yishen Granules Reduce Inflammation and Improve Pulmonary Function in Acute Exacerbation-Risk Window of Chronic Obstructive Pulmonary Disease in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Xiaofan Lu ◽  
Ya Li ◽  
Jiansheng Li ◽  
Haifeng Wang ◽  
Zhaohuan Wu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Body Temperature ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Bacterial Infections ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Amyloid A ◽  
Sequential Treatments

Background. Sequential treatments of Chinese medicines for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) risk window (RW) have benefits for preventing reoccurrences of AEs; however, the effects on pulmonary function, pulmonary, and systemic inflammatory biomarkers remain unclear.Methods. Cigarette-smoke/bacterial infections induced rats were randomized into Control, COPD, AECOPD, Tongsai Granule/normal saline (TSG/NS), moxifloxacin + salbutamol/NS (MXF+STL/NS), TSG/Bufei Yishen Granule (BYG), MXF+STL/STL, and TSG+MXF+STL/BYG+STL groups and given corresponding medicine(s) in AE- and/or RW phase. Body temperature, pulmonary function, blood cytology, serum amyloid A (SAA) and C-reactive protein (CRP), pulmonary histomorphology and myeloperoxidase (MPO), polymorphonuclear (PMN) elastase, interleukins IL-1β, IL-6, and IL-10, and tumor necrosis factor- (TNF-)αexpressions were determined.Results. Body temperature, inflammatory cells and cytokines, SAA, CRP, and pulmonary impairment were higher in AECOPD rats than stable COPD, while pulmonary function declined and recovered to COPD level in 14–18 days. All biomarkers were improved in treated groups with shorter recovery times of 4–10 days, especially in TSG+MXF+STL/BYG+STL group.Conclusion. Sequential treatments with Tongsai and Bufei Yishen Granules, during AECOPD-RW periods, can reduce inflammatory response and improve pulmonary function and shorten the recovery courses of AEs, especially the integrated Chinese and Western medicines.

scholarly journals Identifying the most effective tool to assess health status of patients with acute exacerbation of chronic obstructive pulmonary disease -a prospective study

2020 ◽  
Author(s):  
ping chen ◽  
Aiyuan Zhou ◽  
Zijing Zhou ◽  
Dingding Deng ◽  
Yiyang Zhao ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Health Status ◽  
Prospective Study ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
A Prospective Study

Abstract The authors have withdrawn this preprint from Research Square

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