Hepatitis C virus: The role of molecular mimicry in response to interferon treatment

2012 ◽  
Vol 84 (10) ◽  
pp. 1571-1585 ◽  
Author(s):  
Samra Uzicanin ◽  
Yu-Wen Hu ◽  
Husam Alsousi ◽  
Martin Pelchat ◽  
Lynda Rocheleau ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Molecular Mimicry ◽  
Interferon Treatment

scholarly journals Role of molecular mimicry of hepatitis C virus protein with platelet GPIIIa in hepatitis C–related immunologic thrombocytopenia

Blood ◽  
2009 ◽  
Vol 113 (17) ◽  
pp. 4086-4093 ◽  
Author(s):  
Wei Zhang ◽  
Michael A. Nardi ◽  
William Borkowsky ◽  
Zongdong Li ◽  
Simon Karpatkin
Keyword(s):  
Platelet Count ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Molecular Mimicry ◽  
Virus Protein ◽  
Drug Abusers ◽  
Phage Peptide Library ◽  
Hiv 1

Abstract Patients with HIV-1 immune-related thrombocytopenia (HIV-1–ITP) have a unique Ab against platelet GPIIIa49-66 capable of inducing oxidative platelet fragmentation in the absence of complement. HIV-1–seropositive drug abusers are more prone to develop immune thrombocytopenia than non–drug abusers and have a higher coinfection with hepatitis C virus (HCV) than non–drug abusers (90% vs 30%). Molecular mimicry was sought by screening a phage peptide library with anti–GPIIIa49-66 antibody as bait for peptides sharing homology sequences with HCV. Several phage peptide clones had 70% homology with HCV protein. Sera from dually infected thrombocytopenic patients with HCV and HIV-ITP reacted strongly with 4 nonconserved peptides from HCV core envelope 1. Reactivity correlated inversely with platelet count (r2 = 0.7, P < .01). Ab raised against peptide PHC09 in GPIIIa−/− mice induced thrombocytopenia in wild-type mice. Affinity-purified IgG against PHC09 induced oxidative platelet fragmentation in vitro. Drug abusers dually infected with HCV and HIV-1 had a greater incidence and severity of thrombocytopenia as well as titer of anti–GPIIIa49-66/PHC09 Ab. NZB/W F1 mice injected with recombinant core envelope 1 developed Ab versus PHC09 and significantly decreased their platelet count (P < .001). Thus, HCV core envelope 1 can induce thrombocytopenia by molecular mimicry with GPIIIa49-66.

Hepatitis C virus and the controversial role of the interferon sensitivity determining region in the response to interferon treatment

2007 ◽  
Vol 80 (2) ◽  
pp. 247-253 ◽  
Author(s):  
Manuela Torres-Puente ◽  
José M. Cuevas ◽  
Nuria Jiménez-Hernández ◽  
María A. Bracho ◽  
Inmaculada García-Robles ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Interferon Treatment

Role of autophagy in hepatitis C virus replication

2019 ◽  
Author(s):  
WI Twu ◽  
K Tabata ◽  
D Paul ◽  
R Bartenschlager
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication

Role of Hepatitis C Virus Core Antigen Assay in Blood Donors Screening at Zagazig University Hospitals

2018 ◽  
Vol 8 (1) ◽  
pp. 48-54
Author(s):  
Rashed Hassan ◽  
Abdelmonem Elshamy ◽  
Sameh Abdel Monem ◽  
Emad Moustafa ◽  
Essam Wahab
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Donors ◽  
Core Antigen ◽  
University Hospitals ◽  
Virus Core ◽  
Antigen Assay

Hepatitis C virus‐associated indolent B‐cell lymphomas: A review on the role of the new direct antiviral agents therapy

2021 ◽  
Author(s):  
Cesare Mazzaro ◽  
Luigino Dal Maso ◽  
Marcella Visentini ◽  
Anna Ermacora ◽  
Pietro Andreone ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Antiviral Agents ◽  
B Cell Lymphomas ◽  
Direct Antiviral Agents
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